ethacrynic acid has been researched along with Prostatic Neoplasms in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Prostatic Neoplasms: Tumors or cancer of the PROSTATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "EA inhibited STAT3 activation in DU145 prostate cancer cells and consequently decreased the levels of STAT3 target genes such as cyclin A and MCL-1." | 1.56 | Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells. ( Cho Han, D; Kim, SY; Kwon, BM; Lee, YJ; Park, SJ; Song, H; Yoon, YJ, 2020) |
| "Prostate cancer is the most common cancer in the Western world." | 1.46 | Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide. ( Messina, CS; Schmidt-Wolf, IG; Weiher, H, 2017) |
| "Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans." | 1.29 | Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bryant, ZE | 1 |
| Janser, RF | 1 |
| Jabarkhail, M | 1 |
| Candelaria-Lyons, MS | 1 |
| Romero, BB | 1 |
| Van slambrouck, S | 1 |
| Steelant, WF | 1 |
| Janser, I | 1 |
| Lee, YJ | 1 |
| Song, H | 1 |
| Yoon, YJ | 1 |
| Park, SJ | 1 |
| Kim, SY | 1 |
| Cho Han, D | 1 |
| Kwon, BM | 1 |
| Messina, CS | 1 |
| Weiher, H | 1 |
| Schmidt-Wolf, IG | 1 |
| Khil, MS | 1 |
| Kim, SH | 1 |
| Pinto, JT | 1 |
| Kim, JH | 1 |
4 other studies available for ethacrynic acid and Prostatic Neoplasms
| Article | Year |
|---|---|
Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Ethacrynic Acid; Humans; Ketones; Male; Phen | 2011 |
Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Fem | 2020 |
Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Ciclopirox; Drug Synergism; Ethacrynic Acid; Humans; | 2017 |
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma | 1996 |