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ethacrynic acid and Prostatic Neoplasms

ethacrynic acid has been researched along with Prostatic Neoplasms in 4 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Prostatic Neoplasms: Tumors or cancer of the PROSTATE.

Research Excerpts

ExcerptRelevanceReference
"EA inhibited STAT3 activation in DU145 prostate cancer cells and consequently decreased the levels of STAT3 target genes such as cyclin A and MCL-1."1.56Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells. ( Cho Han, D; Kim, SY; Kwon, BM; Lee, YJ; Park, SJ; Song, H; Yoon, YJ, 2020)
"Prostate cancer is the most common cancer in the Western world."1.46Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide. ( Messina, CS; Schmidt-Wolf, IG; Weiher, H, 2017)
"Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans."1.29Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Bryant, ZE1
Janser, RF1
Jabarkhail, M1
Candelaria-Lyons, MS1
Romero, BB1
Van slambrouck, S1
Steelant, WF1
Janser, I1
Lee, YJ1
Song, H1
Yoon, YJ1
Park, SJ1
Kim, SY1
Cho Han, D1
Kwon, BM1
Messina, CS1
Weiher, H1
Schmidt-Wolf, IG1
Khil, MS1
Kim, SH1
Pinto, JT1
Kim, JH1

Other Studies

4 other studies available for ethacrynic acid and Prostatic Neoplasms

ArticleYear
Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.
    Bioorganic & medicinal chemistry letters, 2011, Feb-01, Volume: 21, Issue:3

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Ethacrynic Acid; Humans; Ketones; Male; Phen

2011
Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.
    Biochemical pharmacology, 2020, Volume: 175

    Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Fem

2020
Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide.
    Anticancer research, 2017, Volume: 37, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Ciclopirox; Drug Synergism; Ethacrynic Acid; Humans;

2017
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
    International journal of radiation oncology, biology, physics, 1996, Jan-15, Volume: 34, Issue:2

    Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma

1996