ethacrynic acid has been researched along with Pregnancy in 35 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorothiazide is a much more potent inhibitor of alkaline phosphatase than the other three diuretics." | 1.26 | Inhibition of alkaline phosphatase by several diuretics. ( Price, GH, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (88.57) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alparslan, MM | 1 |
| Danış, Ö | 1 |
| McKercher, HG | 2 |
| Derewlany, LO | 2 |
| Radde, IC | 3 |
| Romankiewicz, JA | 1 |
| Lerner, SA | 1 |
| Matz, GJ | 1 |
| Price, GH | 1 |
| Kulkarni, AP | 2 |
| Sajan, MP | 1 |
| Sajan, M | 1 |
| Gnanapragasam, A | 1 |
| Lin, YM | 1 |
| Jarabak, J | 1 |
| Marlowe, FI | 1 |
| Hall, WD | 1 |
| France, VM | 1 |
| Kelly, JV | 1 |
| Davies, DL | 1 |
| Wilson, GM | 1 |
| Pleasure, JR | 1 |
| Blackburn, MG | 1 |
| Loggie, JM | 1 |
| Kleinman, LI | 1 |
| Van Maanen, EF | 1 |
| Dattino, R | 1 |
| Niccoli, V | 1 |
| Dattino, M | 1 |
| Pezzali, E | 1 |
| D'Anna, A | 1 |
| Fischer, AF | 1 |
| Parker, BR | 1 |
| Stevenson, DK | 1 |
| Harrison, KA | 2 |
| Ajabor, LN | 1 |
| Lawson, JB | 1 |
| Sheffield, PA | 1 |
| Turner, JS | 1 |
| Pillay, VK | 1 |
| Schwartz, FD | 1 |
| Aimi, K | 1 |
| Kark, RM | 1 |
| Shami, Y | 1 |
| Jones, HC | 1 |
| Tucker, RM | 1 |
| Hunt, JC | 1 |
| Anderton, JL | 1 |
| Kincaid-Smith, P | 1 |
| Fort, AT | 2 |
| Morrison, JC | 2 |
| Fish, SA | 2 |
| Young, BK | 1 |
| Haft, JI | 1 |
| Felman, D | 1 |
| Theoleyre, J | 1 |
| Dupoizat, H | 1 |
| Delgado Urdapilleta, J | 2 |
| Dominguez Robles, H | 2 |
| Villalobos Roman, M | 1 |
| Perez Diaz, A | 1 |
| Ramírez Soto, E | 1 |
| Bartlett, RH | 1 |
| Yahia, C | 1 |
3 reviews available for ethacrynic acid and Pregnancy
| Article | Year |
|---|---|
Diuretics: mechanism of action and clinical application.
Topics: Acute Kidney Injury; Amiloride; Animals; Benzothiadiazines; Diabetes Insipidus; Diuretics; Diuretics | 1975 |
Recent advances in the medical and surgical treatment of hypertension.
Topics: Adrenocortical Hyperfunction; Antihypertensive Agents; Diet, Sodium-Restricted; Diuretics; Ethacryni | 1968 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
1 trial available for ethacrynic acid and Pregnancy
| Article | Year |
|---|---|
Ethacrynic acid and packed-blood-cell transfusion in treatment of severe anaemia in pregnancy.
Topics: Abortion, Spontaneous; Anemia; Blood Transfusion; Calcium; Diuresis; Ethacrynic Acid; Exchange Trans | 1971 |
31 other studies available for ethacrynic acid and Pregnancy
| Article | Year |
|---|---|
In Vitro Inhibition of Human Placental Glutathione S-Transferase by 3-Arylcoumarin Derivatives.
Topics: Antineoplastic Agents; Coumarins; Dinitrochlorobenzene; Drug Design; Drug Resistance, Neoplasm; Enzy | 2015 |
Placental calcium and phosphorus transfer in the guinea pig: lack of effect of modulators of Ca-ATPase and alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Antipyrine; Calcium; Calcium-Transporting ATPases; Ethacrynic Acid; F | 1983 |
Placental transfer of calcium (Ca) and phosphorus (Pi) in the guinea pig: lack of correlation with placental Ca-ATPase and alkaline phosphatase (AP) activities.
Topics: Alkaline Phosphatase; Animals; Calcium; Calcium-Transporting ATPases; Ethacrynic Acid; Female; Furos | 1983 |
Loop diuretics.
Topics: Adult; Child; Ethacrynic Acid; Female; Furosemide; Humans; Infant; Loop of Henle; Pregnancy | 1982 |
Aminoglycoside ototoxicity.
Topics: Adult; Aminoglycosides; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Ethac | 1980 |
Inhibition of alkaline phosphatase by several diuretics.
Topics: Acetazolamide; Alkaline Phosphatase; Animals; Bone and Bones; Chlorothiazide; Diuretics; Ethacrynic | 1980 |
A novel mechanism of glutathione conjugate formation by lipoxygenase: a study with ethacrynic acid.
Topics: Animals; Chromatography, Thin Layer; Diuretics; Ethacrynic Acid; Female; Glutathione; Glycine max; H | 1997 |
Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid.
Topics: Chromatography, Affinity; Dinitrochlorobenzene; Ethacrynic Acid; Female; Glutathione; Humans; Linole | 1999 |
Ototoxic therapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Deafness; Dihydrostreptomycin Sulfate; Ethacrynic A | 1975 |
Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition.
Topics: Ethacrynic Acid; Female; Furosemide; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Plac | 1978 |
Ototoxic agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Aspirin; Child; Drug-Related Side Effects and Adver | 1978 |
Clinical use of diuretics in congestive heart failure.
Topics: Amiloride; Benzothiadiazines; Diuretics; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; | 1979 |
A possible mechanism for hormone-induced fluid movement across sheep and guinea-pig amnion [proceedings].
Topics: Amnion; Animals; Biological Transport; Chlorides; Ethacrynic Acid; Female; Guinea Pigs; In Vitro Tec | 1977 |
Drugs used in the management of toxemia of pregnancy.
Topics: Anticonvulsants; Antihypertensive Agents; Barbiturates; Benzothiadiazines; Blood Volume; Diazepam; D | 1977 |
Neonatal bromide intoxication: prenatal ingestion of a large quantity of bromides with transplacental accumulation in the fetus.
Topics: Adult; Apgar Score; Bromides; Chlorides; Ethacrynic Acid; Female; Fetal Blood; Fetal Heart; Fetus; H | 1975 |
Renal function and diuretic therapy in infants and children. Part II.
Topics: Acetazolamide; Aldosterone; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Child; Diuretics; Diur | 1975 |
[The indications and need for diuretics in pregnancy].
Topics: Adult; Diuretics; Drug Therapy, Combination; Eclampsia; Ethacrynic Acid; Female; Furosemide; Humans; | 1992 |
Nephrolithiasis following in utero diuretic exposure: an unusual case.
Topics: Ethacrynic Acid; Female; Humans; Infant, Newborn; Kidney Calculi; Nifedipine; Polyhydramnios; Pregna | 1988 |
Ototoxic drugs: a review of clinical aspects, histopathologic changes and mechanisms of action.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Aspirin; Chloroquine; Cochlea; Dihydrostreptomycin Su | 1971 |
Transient and permanent deafness following treatment with ethacrynic acid in renal failure.
Topics: Adult; Amphetamine; Aortic Valve Insufficiency; Aspartate Aminotransferases; Blood Urea Nitrogen; Ca | 1969 |
Calcium-stimulated ATPase of guinea pig placenta.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Calcium; Cell Membrane; Edetic Acid; Enzym | 1971 |
Intrauterine ototoxicity. A case report and review of literature.
Topics: Abnormalities, Drug-Induced; Adult; Deafness; Ear; Ethacrynic Acid; Female; Fetus; Humans; Kanamycin | 1973 |
Diazoxide (hyperstat).
Topics: Blood Pressure; Diazoxide; Ethacrynic Acid; Female; Furosemide; Humans; Hypertension; Hypertension, | 1973 |
Ethacrynic acid in blood transfusion--its effects on plasma volume and urine flow in severe anaemia in pregnancy.
Topics: Anemia; Blood Transfusion; Blood Volume; Diuresis; Dye Dilution Technique; Edema; Ethacrynic Acid; F | 1968 |
Iatrogenic hypokalemia of pregnancy by furosemide and ethacrynic acid.
Topics: Adolescent; Adult; Alkalosis; Ethacrynic Acid; Female; Furosemide; Hearing Disorders; Humans; Hypoka | 1971 |
Treatment of pulmonary edema with ethacrynic acid during labor.
Topics: Adult; Ethacrynic Acid; Female; Heart Diseases; Humans; Obstetric Labor Complications; Pregnancy; Pr | 1970 |
Case report. Diuretic induced ototoxicity in preeclampsia.
Topics: Adult; Ethacrynic Acid; Female; Furosemide; Hearing Disorders; Humans; Kidney Function Tests; Pre-Ec | 1971 |
[Trial of ethacrynic acid in treatment of excessive weight gain and arterial hypertension in pregnancy].
Topics: Adult; Arteries; Body Weight; Diabetes Mellitus; Ethacrynic Acid; Female; Humans; Hypertension; Infa | 1967 |
[Ethacrynic acid in the therapy of pregnancy toxemias].
Topics: Adolescent; Adult; Ethacrynic Acid; Female; Humans; Pre-Eclampsia; Pregnancy | 1968 |
[Comparative study of diuretics in pregnancy toxemia].
Topics: Adult; Calcium; Chlorides; Chlorothiazide; Diuretics; Ethacrynic Acid; Female; Humans; Hydrochloroth | 1969 |
Management of septic chemical abortion with renal failure. Report of five consecutive cases with five survivors.
Topics: Abortion, Criminal; Abortion, Septic; Acute Kidney Injury; Adult; Carbon Dioxide; Ethacrynic Acid; F | 1969 |