ethacrynic acid has been researched along with Nerve Degeneration in 3 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the chinchilla, co-administration of GM and EA can produce hair cell lesions ranging from a small loss of outer hair cells (OHCs) in the base of the cochlea to complete destruction of all hair cells, depending on dosing parameters." | 1.32 | Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla. ( Ding, D; Jiang, H; McFadden, SL; Salvi, RJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McFadden, SL | 1 |
| Ding, D | 1 |
| Jiang, H | 1 |
| Salvi, RJ | 1 |
| Chi, L | 1 |
| Ke, Y | 1 |
| Luo, C | 1 |
| Gozal, D | 1 |
| Liu, R | 1 |
| Rejali, D | 1 |
| Lee, VA | 1 |
| Abrashkin, KA | 1 |
| Humayun, N | 1 |
| Swiderski, DL | 1 |
| Raphael, Y | 1 |
3 other studies available for ethacrynic acid and Nerve Degeneration
| Article | Year |
|---|---|
Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla.
Topics: Acetylcholinesterase; Action Potentials; Animals; Cell Count; Cell Death; Chinchilla; Cochlear Micro | 2004 |
Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Apoptosis Inducing Factor; Biomarkers; Buthionine | 2007 |
Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cochlear I | 2007 |