ethacrynic acid has been researched along with Nephrotic Syndrome in 37 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (97.30) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SCHROEDER, G | 1 |
| SANNERSTEDT, R | 1 |
| WERKOE, L | 1 |
| SPERBER, RJ | 1 |
| DIRE, LB | 1 |
| SINGER, MM | 1 |
| FISCH, S | 1 |
| DEGRAFF, AC | 1 |
| CANNON, PJ | 1 |
| HEINEMANN, HO | 1 |
| STASON, WB | 1 |
| LARAGH, JH | 1 |
| MAHER, JF | 1 |
| SCHREINER, GE | 1 |
| HAGEDORN, CW | 1 |
| KAPLAN, AA | 1 |
| HULET, WH | 1 |
| Soyka, LF | 1 |
| de Sousa, RC | 1 |
| Jenny, M | 1 |
| James, JA | 1 |
| Davies, IB | 1 |
| Lightman, SL | 1 |
| Lewy, JE | 1 |
| Oimomi, M | 1 |
| Takase, S | 1 |
| Saeki, S | 1 |
| Witte, MK | 1 |
| Stork, JE | 1 |
| Blumer, JL | 1 |
| Garnett, ES | 1 |
| Webber, CE | 1 |
| Cieślińska, K | 2 |
| Wójcicki, J | 2 |
| Guédon, J | 1 |
| Legrain, M | 1 |
| Barjon, P | 1 |
| Pelissier, JG | 1 |
| Laroche, C | 1 |
| Grégoire, J | 1 |
| Dzúriková, V | 1 |
| Simoncic, E | 1 |
| Laurincová, K | 1 |
| Dzúrik, R | 1 |
| Murphy, AV | 1 |
| Leiter, L | 1 |
| Radó, JP | 1 |
| Marosi, J | 1 |
| Takó, J | 1 |
| Anderton, JL | 1 |
| Kincaid-Smith, P | 1 |
| Reubi, FC | 1 |
| Grausz, H | 1 |
| Lieberman, R | 1 |
| Earley, LE | 1 |
| Ratner, NA | 1 |
| Glezer, GA | 1 |
| Groznovich, NA | 1 |
| Moskalenko, NP | 1 |
| Hwang, YS | 1 |
| Muth, RG | 1 |
| Clancy, RL | 1 |
| Stiel, JN | 1 |
| Chodakowska, J | 1 |
| Filipecki, S | 1 |
| Koçak, N | 1 |
| Ozdoğan, E | 1 |
| Iványi, J | 1 |
| Ledingham, JG | 1 |
| Bayliss, RI | 1 |
| Wayne, HH | 1 |
| Kotler, SA | 1 |
| McGirr, PS | 1 |
| Stoike, RD | 1 |
| Stewart, JH | 1 |
| Edwards, KD | 1 |
| Doyle, AE | 1 |
| Ekert, H | 1 |
| Trevaks, G | 1 |
| Ozen, MA | 1 |
| Sandalci, O | 1 |
| Berker, F | 1 |
6 reviews available for ethacrynic acid and Nephrotic Syndrome
| Article | Year |
|---|---|
Refractory oedema.
Topics: Aminophylline; Bumetanide; Diuretics; Drug Therapy, Combination; Edema; Edema, Cardiac; Ethacrynic A | 1980 |
Diuretics in infancy.
Topics: Acute Disease; Benzothiadiazines; Diet, Sodium-Restricted; Diuretics; Diuretics, Osmotic; Edema; Eth | 1981 |
Diuretic therapeutics in the pediatric patient.
Topics: Acid-Base Equilibrium; Bumetanide; Calcium; Child; Child, Preschool; Chlorides; Diuretics; Ethacryni | 1986 |
Combinations of diuretics in the treatment of edema.
Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu | 1970 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
Combination diuretic drug therapy.
Topics: Amiloride; Benzothiadiazines; Diet; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Furosemid | 1971 |
3 trials available for ethacrynic acid and Nephrotic Syndrome
| Article | Year |
|---|---|
[Use of ethacrynic acid in the teatment of edematous states].
Topics: Clinical Trials as Topic; Drug Evaluation; Edema; Ethacrynic Acid; Heart Failure; Humans; Liver Cirr | 1973 |
High doses of spironolactone (Aldactone, SC-14266, Verospirone) alone and in combination with triamterene and-or diuretics in the treatment of refractory edema associated with secondary hyperaldosteronism.
Topics: Adult; Aged; Body Weight; Chlorides; Clinical Trials as Topic; Clopamide; Creatinine; Diet, Sodium-R | 1970 |
Clinical comparison of frusemide with bendrofluazide, mersalyl, and ethacrynic acid.
Topics: Adult; Aged; Bendroflumethiazide; Diuretics; Edema; Ethacrynic Acid; Female; Furosemide; Heart Failu | 1965 |
28 other studies available for ethacrynic acid and Nephrotic Syndrome
| Article | Year |
|---|---|
CLINICAL EXPERIENCES WITH ETHACRYNIC ACID, A NEW NON-THIAZIDE SALURETIC AGENT (MK-595).
Topics: Aneurysm; Arteriosclerosis; Biomedical Research; Blood; Body Weight; Creatine; Creatinine; Diabetes | 1964 |
ETHACRYNIC ACID IN PATHOLOGICAL FLUID RETENTION.
Topics: Digoxin; Diuretics; Drug Therapy; Ethacrynic Acid; Geriatrics; Heart Failure; Humans; Hydrochlorothi | 1965 |
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors; | 1965 |
STUDIES ON ETHACRYNIC ACID IN PATIENTS WITH REFRACTORY EDEMA.
Topics: Alkalosis; Blood; Chlorides; Creatine; Creatinine; Diuretics; Drug Therapy; Edema; Ethacrynic Acid; | 1965 |
PROLONGED ADMINISTRATION OF ETHACRYNIC ACID IN PATIENTS WITH CHRONIC RENAL DISEASE.
Topics: Acid-Base Equilibrium; Diabetic Nephropathies; Diarrhea; Diuretics; Drug Therapy; Edema; Ethacrynic | 1965 |
The nephrotic syndrome: current concepts in diagnosis and therapy advantages of alternate day steroid regimen.
Topics: Alkylating Agents; Anti-Bacterial Agents; Child; Child, Preschool; Ethacrynic Acid; Humans; Hydralaz | 1967 |
Clinical study of a new diuretic--ethacrynic acid.
Topics: Alkalosis; Ascites; Blood; Body Weight; Chlorides; Edema; Ethacrynic Acid; Heart Failure; Humans; Li | 1967 |
Ethacrynic acid in edematous states in children.
Topics: Alkalosis; Bicarbonates; Body Weight; Child; Child, Preschool; Chlorides; Ethacrynic Acid; Glomerulo | 1967 |
Combination diuretic therapy for severe refractory nephrotic syndrome.
Topics: Adolescent; Adult; Chlorthalidone; Drug Therapy, Combination; Ethacrynic Acid; Female; Furosemide; H | 1990 |
Changes in blood-volume produced by treatment in the nephrotic syndrome.
Topics: Adolescent; Adult; Aged; Blood Volume; Blood Volume Determination; Body Weight; Child; Chlorothiazid | 1967 |
[Treatment of nephrotic syndromes with cynarine].
Topics: Adult; Cinnamates; Cyclohexanecarboxylic Acids; Drug Synergism; Ethacrynic Acid; Evaluation Studies | 1974 |
Diuretics in chronic renal insufficiency.
Topics: Dose-Response Relationship, Drug; Ethacrynic Acid; Furosemide; Humans; Kidney Failure, Chronic; Neph | 1972 |
[The treatment of hydropigenous syndromes with ethacrynic acid. (Apropos of 100 cases)].
Topics: Adult; Aged; Diuretics; Edema; Ethacrynic Acid; Heart Failure; Humans; Liver Cirrhosis; Middle Aged; | 1967 |
[Clinical trials of ethacrynic acid].
Topics: Adult; Ascites; Edema; Ethacrynic Acid; Female; Heart Failure; Humans; Liver Cirrhosis; Male; Middle | 1967 |
Value and toxicity of therapy for idiopathic nephrotic syndrome in the child.
Topics: Anti-Bacterial Agents; Blood Protein Disorders; Child; Chlorothiazide; Cyclophosphamide; Diet, Sodiu | 1973 |
[Treatment of nephrotic syndromes with cynarine].
Topics: Adult; Cinnamates; Cyclohexanecarboxylic Acids; Drug Synergism; Ethacrynic Acid; Evaluation Studies | 1974 |
Effect of plasma albumin on sodium reabsorption in patients with nephrotic syndrome.
Topics: Aminohippuric Acids; Blood Proteins; Chlorothiazide; Edema; Ethacrynic Acid; Glomerular Filtration R | 1972 |
[Diuretic and hypotensive action of uregite (ethacrynic acid)].
Topics: Amyloidosis; Arteries; Blood Pressure; Diuresis; Ethacrynic Acid; Familial Mediterranean Fever; Glom | 1971 |
[The diuretic activity of ethacrynic acid].
Topics: Adolescent; Adult; Diabetic Nephropathies; Diuresis; Electrocardiography; Ethacrynic Acid; Female; H | 1969 |
Diuretics in renal disease.
Topics: Adult; Diuresis; Diuretics; Ethacrynic Acid; Female; Furosemide; Humans; Kidney Diseases; Kidney Fai | 1969 |
Familial Mediterranean fever with amyloidosis.
Topics: Adult; Amyloid; Amyloidosis; Bendroflumethiazide; Blood Proteins; Diet Therapy; Electrophoresis; Eth | 1968 |
Ethacrynic acid in patients with salt and water retention-a clinical appraisal.
Topics: Chlorides; Edema; Ethacrynic Acid; Heart Failure; Humans; Hypernatremia; Hyponatremia; Kidney Failur | 1968 |
[Effect of a new oral diuretic, ethacrynic acid, in normal individuals and patients with cardiac or nephrotic syndrome on diuresis and renal function].
Topics: Ethacrynic Acid; Heart Failure; Humans; Injections, Intravenous; Kidney Function Tests; Nephrotic Sy | 1968 |
[Experiences with ethacrynic acid (Edecrin)].
Topics: Cardiovascular Diseases; Diuretics; Edema; Ethacrynic Acid; Extremities; Humans; Liver Cirrhosis; Ne | 1969 |
Ethacrynic acid: two years' experience with a new diuretic.
Topics: Benzothiadiazines; Blood; Edema; Ethacrynic Acid; Heart Failure; Liver Cirrhosis; Nephrotic Syndrome | 1965 |
Ethacrynic acid. Use in ambulatory patients with resistant edema.
Topics: Adolescent; Adult; Aged; Blood; Chlorides; Edema; Electrolytes; Ethacrynic Acid; Female; Heart Failu | 1965 |
Ethacrynic acid in the treatment of patients resistant to thiazides.
Topics: Diuretics; Edema; Ethacrynic Acid; Heart Failure; Humans; Liver Cirrhosis; Nephrotic Syndrome | 1966 |
Ethacrynic acid and carbohydrate metabolism.
Topics: Adult; Aged; Arteriosclerosis; Carbohydrate Metabolism; Edema; Ethacrynic Acid; Glucose Tolerance Te | 1966 |