ethacrynic acid has been researched along with Neoplasms in 16 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Ethacrynic acid (EA) is an inhibitor of the glutathione S-transferases (GSTs), a family of detoxification enzymes the expression of which has been associated with resistance to several classes of anticancer drugs." | 2.67 | Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer. ( Brennan, JM; Comis, RL; Lacreta, FP; Nash, SL; O'Dwyer, PJ; Tew, KD, 1994) |
| "Ethacrynic acid (EA) is a diuretic drug that is widely used to treat high-blood pressure and swelling caused by congestive heart failure or kidney failure." | 1.48 | Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. ( Chen, X; Lei, X; Song, T; Wang, C; Ye, Z; Zhang, X; Zhu, Y, 2018) |
| "Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors." | 1.37 | Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation. ( Aitken, JB; Ang, WH; Ascher, DB; Campomanes, P; De Luca, A; Dyson, PJ; Hancock, NC; Harris, HH; Italiano, LC; Lo Bello, M; Morton, CJ; Parker, LJ; Parker, MW; Rothlisberger, U, 2011) |
| "Ethacrynic acid (EA) is a glutathione S-transferase P1-1 (GST P1-1) inhibitor with weak antiproliferative ability in tumor cells." | 1.36 | Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation. ( Jing, Y; Li, C; Li, H; Liang, W; Liu, B; Liu, G; Song, D; Wang, R; Yang, X; Zhang, Y; Zhao, G, 2010) |
| "Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans." | 1.29 | Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Yang, X | 1 |
| Liu, G | 1 |
| Li, H | 2 |
| Zhang, Y | 1 |
| Song, D | 1 |
| Li, C | 2 |
| Wang, R | 1 |
| Liu, B | 1 |
| Liang, W | 1 |
| Jing, Y | 1 |
| Zhao, G | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Won, M | 1 |
| Koo, S | 1 |
| Sessler, JL | 1 |
| Lee, JY | 1 |
| Sharma, A | 1 |
| Kim, JS | 1 |
| Li, S | 1 |
| Jin, S | 1 |
| Liu, J | 1 |
| Xue, X | 1 |
| Eltahan, AS | 1 |
| Sun, J | 1 |
| Tan, J | 1 |
| Dong, J | 1 |
| Liang, XJ | 1 |
| Ye, Z | 1 |
| Zhang, X | 1 |
| Zhu, Y | 1 |
| Song, T | 1 |
| Chen, X | 1 |
| Lei, X | 1 |
| Wang, C | 1 |
| Musdal, Y | 1 |
| Hegazy, UM | 1 |
| Aksoy, Y | 1 |
| Mannervik, B | 1 |
| Su, YH | 1 |
| Chiang, LW | 1 |
| Jeng, KC | 1 |
| Huang, HL | 1 |
| Chen, JT | 1 |
| Lin, WJ | 1 |
| Huang, CW | 1 |
| Yu, CS | 1 |
| Parker, LJ | 1 |
| Italiano, LC | 1 |
| Morton, CJ | 1 |
| Hancock, NC | 1 |
| Ascher, DB | 1 |
| Aitken, JB | 1 |
| Harris, HH | 1 |
| Campomanes, P | 1 |
| Rothlisberger, U | 1 |
| De Luca, A | 1 |
| Lo Bello, M | 1 |
| Ang, WH | 1 |
| Dyson, PJ | 1 |
| Parker, MW | 1 |
| Hamilton, D | 1 |
| Fotouhi-Ardakani, N | 1 |
| Batist, G | 1 |
| Lacreta, FP | 1 |
| Brennan, JM | 1 |
| Nash, SL | 1 |
| Comis, RL | 2 |
| Tew, KD | 2 |
| O'Dwyer, PJ | 2 |
| Khil, MS | 1 |
| Kim, SH | 1 |
| Pinto, JT | 1 |
| Kim, JH | 1 |
| LaCreta, F | 1 |
| Nash, S | 1 |
| Tinsley, PW | 1 |
| Schilder, R | 1 |
| Clapper, ML | 1 |
| Panting, L | 1 |
| Litwin, S | 1 |
| Lenhard, RE | 1 |
| Deftos, LJ | 1 |
| Neer, R | 1 |
| Walser, M | 1 |
5 reviews available for ethacrynic acid and Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
The glutathione system in alkylator resistance.
Topics: Alkylating Agents; Anticarcinogenic Agents; Buthionine Sulfoximine; Enzyme Inhibitors; Ethacrynic Ac | 2002 |
Medical management of the hypercalcemia of malignancy.
Topics: Bone Neoplasms; Calcitonin; Citrates; Edetic Acid; Ethacrynic Acid; Furosemide; Glucocorticoids; Hum | 1974 |
Treatment of hypercalcemias.
Topics: Administration, Oral; Calcitonin; Calcium, Dietary; Citrates; Diuretics; Edetic Acid; Ethacrynic Aci | 1970 |
3 trials available for ethacrynic acid and Neoplasms
| Article | Year |
|---|---|
Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer.
Topics: Aged; Biological Availability; Cross-Over Studies; Diuresis; Drug Resistance; Ethacrynic Acid; Femal | 1994 |
Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Tolerance; Ethacr | 1991 |
Clinical case records in chemotherapy: the management of hypercalcemia complicating cancer.
Topics: Adult; Aged; Breast Neoplasms; Calcium; Citrates; Clinical Trials as Topic; Cyclophosphamide; Edetic | 1971 |
8 other studies available for ethacrynic acid and Neoplasms
| Article | Year |
|---|---|
Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation.
Topics: Antineoplastic Agents; Cell Proliferation; Ethacrynic Acid; Glutathione S-Transferase pi; Humans; Mo | 2010 |
An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy.
Topics: Animals; Apoptosis; Boron Compounds; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Ethacrynic Acid; | 2021 |
Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Delayed-Action Preparations; Drug Deliv | 2017 |
Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function.
Topics: Cell Line, Tumor; Cysteine; Drug Repositioning; Drug Screening Assays, Antitumor; Ethacrynic Acid; H | 2018 |
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.
Topics: Antineoplastic Agents; Chlorophyllides; Drug Approval; Drug Evaluation, Preclinical; Drug Resistance | 2013 |
Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Ethacrynic | 2011 |
Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
Topics: Animals; Antineoplastic Agents; Cisplatin; Crystallography, X-Ray; Dimerization; Enzyme Inhibitors; | 2011 |
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma | 1996 |