ethacrynic acid has been researched along with Malignant Melanoma in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have investigated the effect of the glutathione transferase inhibitor by ethacrynic acid on the cytotoxicity of melphalan to a human melanoma cell line (RPMI 8322) with a high level of glutathione transferase activity." | 7.68 | Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid. ( Berhane, K; Castro, VM; Hansson, J; Jungnelius, U; Mannervik, B; Ringborg, U, 1991) |
| "Curcumin was the most potent inhibitor (96% inhibition at 25 microM), while 67 and 61% inhibition at 25 microM was observed for ethacrynic acid and trans-2-hexenal, respectively." | 5.29 | Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. ( Iersel, ML; Keyzer, AE; Ploemen, JP; Schefferlie, JG; Struik, I; van Amersfoort, C; van Bladeren, PJ, 1996) |
| " We have investigated the effect of the glutathione transferase inhibitor by ethacrynic acid on the cytotoxicity of melphalan to a human melanoma cell line (RPMI 8322) with a high level of glutathione transferase activity." | 3.68 | Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid. ( Berhane, K; Castro, VM; Hansson, J; Jungnelius, U; Mannervik, B; Ringborg, U, 1991) |
| "Curcumin was the most potent inhibitor (96% inhibition at 25 microM), while 67 and 61% inhibition at 25 microM was observed for ethacrynic acid and trans-2-hexenal, respectively." | 1.29 | Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. ( Iersel, ML; Keyzer, AE; Ploemen, JP; Schefferlie, JG; Struik, I; van Amersfoort, C; van Bladeren, PJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Supino, R | 1 |
| Caserini, C | 1 |
| Orlandi, L | 1 |
| Zaffaroni, N | 1 |
| Silvestrini, R | 1 |
| Vaglini, M | 1 |
| Zunino, F | 1 |
| Iersel, ML | 1 |
| Ploemen, JP | 1 |
| Struik, I | 1 |
| van Amersfoort, C | 1 |
| Keyzer, AE | 1 |
| Schefferlie, JG | 1 |
| van Bladeren, PJ | 2 |
| van Iersel, ML | 1 |
| van Lipzig, MM | 1 |
| Rietjens, IM | 1 |
| Vervoort, J | 1 |
| Hansson, J | 1 |
| Berhane, K | 1 |
| Castro, VM | 1 |
| Jungnelius, U | 1 |
| Mannervik, B | 1 |
| Ringborg, U | 1 |
4 other studies available for ethacrynic acid and Malignant Melanoma
| Article | Year |
|---|---|
Modulation of melphalan cytotoxic activity in human melanoma cell lines.
Topics: Antineoplastic Agents, Alkylating; Blotting, Northern; Camptothecin; Drug Interactions; Enzyme Inhib | 1996 |
Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
Topics: Acrolein; Acyclic Monoterpenes; Aldehydes; Chromatography, High Pressure Liquid; Curcumin; Enzyme In | 1996 |
GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.
Topics: Amino Acid Substitution; Ethacrynic Acid; Glutathione; Glutathione Transferase; Humans; Isoenzymes; | 1998 |
Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid.
Topics: Cell Survival; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Synergism; Ethacrynic | 1991 |