Page last updated: 2024-10-26

ethacrynic acid and Lung Neoplasms

ethacrynic acid has been researched along with Lung Neoplasms in 7 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells."5.91Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023)
"Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells."1.91Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023)
"Ethacrynic acid (ECA) is a diuretic that inhibits cellular ion flux and exerts anticancer effects."1.62Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling. ( Byun, HJ; Kang, GJ; Kim, B; Kim, EJ; Kim, HJ; Kim, JH; Kim, SY; Lee, CH; Lee, H; Nguyen, MT; Park, MK; Rho, SB; Yu, L, 2021)
" Addition of ethacrynic acid (3 micrograms ml-1) to treatment of the cell lines with melphalan or with cisplatin did not alter the dose-response curves to these agents."1.28A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines. ( Rhodes, T; Twentyman, PR, 1992)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's4 (57.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Yu, L2
Ji Kim, H1
Kim, B2
Jung Byun, H1
Minh Nguyen, T1
Ji Kim, E1
Huy Phùng, H1
Hyeon Kim, Y1
Rahman, M1
Yun Jang, J1
Bae Rho, S1
Jin Kang, G1
Lee, H2
Lee, K1
Kyung Han, H1
Kyung Park, M1
Hoon Lee, C1
Kim, HJ1
Park, MK1
Byun, HJ1
Kim, EJ1
Nguyen, MT1
Kim, JH1
Kang, GJ1
Kim, SY1
Rho, SB1
Lee, CH1
Zaman, GJ1
Cnubben, NH1
van Bladeren, PJ1
Evers, R1
Borst, P1
Awasthi, S1
Singhal, SS1
He, N1
Chaubey, M1
Zimniak, P1
Srivastava, SK1
Singh, SV1
Awasthi, YC1
Rhodes, T1
Twentyman, PR1
Brodie, AE1
Reed, DJ1
Murphy, GP1
Mirand, EA1
Johnston, GS1
Gibbons, RP1
Schirmer, HK1
Scott, WW1

Other Studies

7 other studies available for ethacrynic acid and Lung Neoplasms

ArticleYear
Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway.
    Biochemical pharmacology, 2023, Volume: 212

    Topics: Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition;

2023
Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling.
    Biochemical pharmacology, 2021, Volume: 183

    Topics: A549 Cells; Animals; Cell Movement; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transit

2021
Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP.
    FEBS letters, 1996, Aug-05, Volume: 391, Issue:1-2

    Topics: Adenosine Monophosphate; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Non-Sma

1996
Modulation of doxorubicin cytotoxicity by ethacrynic acid.
    International journal of cancer, 1996, Nov-04, Volume: 68, Issue:3

    Topics: Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Sma

1996
A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines.
    British journal of cancer, 1992, Volume: 65, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Dr

1992
Cellular recovery of glyceraldehyde-3-phosphate dehydrogenase activity and thiol status after exposure to hydroperoxides.
    Archives of biochemistry and biophysics, 1990, Volume: 276, Issue:1

    Topics: Cell Line; Cysteamine; Cysteine; Cystine; Dithiothreitol; Ethacrynic Acid; Ethylmaleimide; Glutathio

1990
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
    The Journal of urology, 1968, Volume: 99, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El

1968