ethacrynic acid has been researched along with Lung Neoplasms in 7 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells." | 5.91 | Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023) |
| "Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells." | 1.91 | Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023) |
| "Ethacrynic acid (ECA) is a diuretic that inhibits cellular ion flux and exerts anticancer effects." | 1.62 | Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling. ( Byun, HJ; Kang, GJ; Kim, B; Kim, EJ; Kim, HJ; Kim, JH; Kim, SY; Lee, CH; Lee, H; Nguyen, MT; Park, MK; Rho, SB; Yu, L, 2021) |
| " Addition of ethacrynic acid (3 micrograms ml-1) to treatment of the cell lines with melphalan or with cisplatin did not alter the dose-response curves to these agents." | 1.28 | A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines. ( Rhodes, T; Twentyman, PR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, L | 2 |
| Ji Kim, H | 1 |
| Kim, B | 2 |
| Jung Byun, H | 1 |
| Minh Nguyen, T | 1 |
| Ji Kim, E | 1 |
| Huy Phùng, H | 1 |
| Hyeon Kim, Y | 1 |
| Rahman, M | 1 |
| Yun Jang, J | 1 |
| Bae Rho, S | 1 |
| Jin Kang, G | 1 |
| Lee, H | 2 |
| Lee, K | 1 |
| Kyung Han, H | 1 |
| Kyung Park, M | 1 |
| Hoon Lee, C | 1 |
| Kim, HJ | 1 |
| Park, MK | 1 |
| Byun, HJ | 1 |
| Kim, EJ | 1 |
| Nguyen, MT | 1 |
| Kim, JH | 1 |
| Kang, GJ | 1 |
| Kim, SY | 1 |
| Rho, SB | 1 |
| Lee, CH | 1 |
| Zaman, GJ | 1 |
| Cnubben, NH | 1 |
| van Bladeren, PJ | 1 |
| Evers, R | 1 |
| Borst, P | 1 |
| Awasthi, S | 1 |
| Singhal, SS | 1 |
| He, N | 1 |
| Chaubey, M | 1 |
| Zimniak, P | 1 |
| Srivastava, SK | 1 |
| Singh, SV | 1 |
| Awasthi, YC | 1 |
| Rhodes, T | 1 |
| Twentyman, PR | 1 |
| Brodie, AE | 1 |
| Reed, DJ | 1 |
| Murphy, GP | 1 |
| Mirand, EA | 1 |
| Johnston, GS | 1 |
| Gibbons, RP | 1 |
| Schirmer, HK | 1 |
| Scott, WW | 1 |
7 other studies available for ethacrynic acid and Lung Neoplasms
| Article | Year |
|---|---|
Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway.
Topics: Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; | 2023 |
Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling.
Topics: A549 Cells; Animals; Cell Movement; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transit | 2021 |
Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP.
Topics: Adenosine Monophosphate; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Non-Sma | 1996 |
Modulation of doxorubicin cytotoxicity by ethacrynic acid.
Topics: Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Sma | 1996 |
A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Dr | 1992 |
Cellular recovery of glyceraldehyde-3-phosphate dehydrogenase activity and thiol status after exposure to hydroperoxides.
Topics: Cell Line; Cysteamine; Cysteine; Cystine; Dithiothreitol; Ethacrynic Acid; Ethylmaleimide; Glutathio | 1990 |
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El | 1968 |