ethacrynic acid has been researched along with Leukemia in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "3 microM, ethacrynic acid was toxic to 8 of 24 (33%) tumor specimens studied." | 1.28 | Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues. ( Kern, DH; Messenger, JC; Nagourney, RA; Weisenthal, LM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, G | 1 |
| Liu, C | 1 |
| Wang, R | 1 |
| Song, D | 1 |
| Wang, X | 1 |
| Lou, H | 1 |
| Jing, Y | 1 |
| Nagourney, RA | 1 |
| Messenger, JC | 1 |
| Kern, DH | 1 |
| Weisenthal, LM | 1 |
2 other studies available for ethacrynic acid and Leukemia
| Article | Year |
|---|---|
The synthesis of alpha,beta-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S-transferase P1-1 activity and the proliferation of leukemia cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, Thin Layer; Enzyme Inhi | 2007 |
Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues.
Topics: Cell Survival; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Ethacrynic Acid; Human | 1990 |