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ethacrynic acid and Leucocythaemia

ethacrynic acid has been researched along with Leucocythaemia in 2 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Research Excerpts

ExcerptRelevanceReference
"3 microM, ethacrynic acid was toxic to 8 of 24 (33%) tumor specimens studied."1.28Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues. ( Kern, DH; Messenger, JC; Nagourney, RA; Weisenthal, LM, 1990)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhao, G1
Liu, C1
Wang, R1
Song, D1
Wang, X1
Lou, H1
Jing, Y1
Nagourney, RA1
Messenger, JC1
Kern, DH1
Weisenthal, LM1

Other Studies

2 other studies available for ethacrynic acid and Leucocythaemia

ArticleYear
The synthesis of alpha,beta-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S-transferase P1-1 activity and the proliferation of leukemia cells.
    Bioorganic & medicinal chemistry, 2007, Apr-01, Volume: 15, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, Thin Layer; Enzyme Inhi

2007
Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:5

    Topics: Cell Survival; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Ethacrynic Acid; Human

1990