ethacrynic acid has been researched along with Kidney Failure in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The sensitivity of this species to renal failure restricted the dose of EA that could be safely administered." | 1.29 | Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid. ( Clark, GM; Shepherd, RK; Xu, SA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shepherd, RK | 1 |
| Xu, SA | 1 |
| Clark, GM | 1 |
1 other study available for ethacrynic acid and Kidney Failure
| Article | Year |
|---|---|
Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Auditory Threshold; Dose-Response Relationship, Drug; Drug Synergism; Ethacrynic Acid; Evok | 1994 |