ethacrynic acid has been researched along with Intraocular Pressure in 16 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 7.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
| "Ethacrynic acid (ECA) lowers intraocular pressure (i." | 7.70 | Effects of ethacrynic acid on intraocular pressure of anesthetized rats. ( Balaban, CD; Johnson, M; Searles, RV; Severs, WB; Shikher, V, 1999) |
| "To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 7.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
| "We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma." | 7.68 | The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992) |
| "We evaluated the effect of topical ethacrynic acid on rabbit and monkey intraocular pressure." | 7.68 | Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys. ( Epstein, DL; Epstein, MP; Schroeder, A; Tingey, DP, 1992) |
| " Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0." | 5.34 | Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007) |
| "Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 3.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
| "Ethacrynic acid (ECA) lowers intraocular pressure (i." | 3.70 | Effects of ethacrynic acid on intraocular pressure of anesthetized rats. ( Balaban, CD; Johnson, M; Searles, RV; Severs, WB; Shikher, V, 1999) |
| "To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 3.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
| "5% ethacrynic acid (ECA) in ointment on intraocular pressure (IOP) and outflow facility following 5 days of topical treatment in ocular normotensive cynomolgus monkeys." | 3.69 | Effect of daily topical ethacrynic acid on aqueous humor dynamics in monkeys. ( Croft, MA; Kaufman, PL, 1995) |
| "We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma." | 3.68 | The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992) |
| "We evaluated the effect of topical ethacrynic acid on rabbit and monkey intraocular pressure." | 3.68 | Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys. ( Epstein, DL; Epstein, MP; Schroeder, A; Tingey, DP, 1992) |
| "Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma." | 1.35 | Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. ( Arnold, JJ; Challa, P; Chen, X; Choksi, Y; Epstein, DL; Hatten, J; Shimazaki, A; Toone, EJ, 2009) |
| " Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0." | 1.34 | Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007) |
| "Intraocular pressure was continuously recorded for up to two weeks after exposure." | 1.29 | Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture. ( Johnson, DH; Tschumper, RC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnold, JJ | 1 |
| Choksi, Y | 1 |
| Chen, X | 1 |
| Shimazaki, A | 4 |
| Hatten, J | 1 |
| Toone, EJ | 1 |
| Epstein, DL | 8 |
| Challa, P | 2 |
| Wang, Y | 1 |
| Yuan, F | 1 |
| Ichikawa, M | 2 |
| Rao, PV | 3 |
| Kirihara, T | 2 |
| Konomi, K | 1 |
| Hara, H | 1 |
| Franse-Carman, L | 1 |
| Alvarado, JA | 1 |
| Tajima, H | 1 |
| Matsugi, T | 1 |
| Croft, MA | 2 |
| Hubbard, WC | 1 |
| Kaufman, PL | 2 |
| Wang, RF | 1 |
| Podos, SM | 1 |
| Serle, JB | 1 |
| Lee, PY | 1 |
| Neufeld, AH | 1 |
| Deschenes, R | 1 |
| Johnson, DH | 1 |
| Tschumper, RC | 1 |
| Toczołowski, J | 1 |
| Woźniak, D | 1 |
| Searles, RV | 1 |
| Johnson, M | 1 |
| Shikher, V | 1 |
| Balaban, CD | 1 |
| Severs, WB | 1 |
| Deshpande, G | 1 |
| Schoenwald, RD | 1 |
| Barfknecht, CF | 1 |
| Duffel, MW | 1 |
| Melamed, S | 1 |
| Kotas-Neumann, R | 1 |
| Barak, A | 1 |
| Tingey, DP | 2 |
| Schroeder, A | 2 |
| Epstein, MP | 1 |
| Ozment, RR | 1 |
| Peczon, JD | 1 |
| Grant, WM | 1 |
16 other studies available for ethacrynic acid and Intraocular Pressure
| Article | Year |
|---|---|
Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
Topics: Administration, Topical; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cin | 2009 |
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni | 2004 |
Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
Topics: Animals; Cats; Cinnamates; Cornea; Diuretics; Dose-Response Relationship, Drug; Ethacrynic Acid; Int | 2004 |
Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
Topics: Actins; Aqueous Humor; Cell Culture Techniques; Cell Shape; Cell Survival; Cinnamates; Cytoskeleton; | 2005 |
Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
Topics: Administration, Topical; Animals; Cats; Cinnamates; Corneal Diseases; Diuretics; Epithelium, Corneal | 2007 |
Effect of ethacrynic acid on aqueous outflow dynamics in monkeys.
Topics: Animals; Aqueous Humor; Dose-Response Relationship, Drug; Ethacrynic Acid; Female; Intraocular Press | 1994 |
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic A | 1994 |
Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture.
Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Culture Media; Ethacrynic Acid; Humans; Intraocular P | 1993 |
Effect of daily topical ethacrynic acid on aqueous humor dynamics in monkeys.
Topics: Administration, Topical; Animals; Aqueous Humor; Ethacrynic Acid; Eye; Female; Intraocular Pressure; | 1995 |
[Studies of changes in filtration angle after experimental administration of ethacrynic acid into the anterior chamber].
Topics: Animals; Anterior Chamber; Ethacrynic Acid; Intraocular Pressure; Rabbits; Trabecular Meshwork | 1996 |
Effects of ethacrynic acid on intraocular pressure of anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Ethacrynic Acid; Infusion Pumps; Intraocular Pressure; Male; Mo | 1999 |
In vitro and ex vivo hydrolysis rates of ethacrynate esters and their relationship to intraocular pressure in the rabbit eye.
Topics: Administration, Topical; Animals; Anterior Eye Segment; Aqueous Humor; Chromatography, High Pressure | 2000 |
The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Endothelium, Corneal; Ethacrynic Acid; | 1992 |
Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys.
Topics: Acetylcysteine; Animals; Corneal Edema; Dose-Response Relationship, Drug; Drug Combinations; Ethacry | 1992 |
The effect of intracameral ethacrynic acid on the intraocular pressure of living monkeys.
Topics: Animals; Anterior Eye Segment; Corneal Edema; Ethacrynic Acid; Injections; Intraocular Pressure; Mac | 1992 |
Diuretic drugs in glaucoma.
Topics: Acetazolamide; Adult; Bendroflumethiazide; Chlormerodrin; Diuretics; Ethacrynic Acid; Furosemide; Gl | 1968 |