Page last updated: 2024-10-26

ethacrynic acid and Intraocular Pressure

ethacrynic acid has been researched along with Intraocular Pressure in 16 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."7.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"Ethacrynic acid (ECA) lowers intraocular pressure (i."7.70Effects of ethacrynic acid on intraocular pressure of anesthetized rats. ( Balaban, CD; Johnson, M; Searles, RV; Severs, WB; Shikher, V, 1999)
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma."7.69Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994)
"We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma."7.68The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992)
"We evaluated the effect of topical ethacrynic acid on rabbit and monkey intraocular pressure."7.68Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys. ( Epstein, DL; Epstein, MP; Schroeder, A; Tingey, DP, 1992)
" Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0."5.34Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."3.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"Ethacrynic acid (ECA) lowers intraocular pressure (i."3.70Effects of ethacrynic acid on intraocular pressure of anesthetized rats. ( Balaban, CD; Johnson, M; Searles, RV; Severs, WB; Shikher, V, 1999)
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma."3.69Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994)
"5% ethacrynic acid (ECA) in ointment on intraocular pressure (IOP) and outflow facility following 5 days of topical treatment in ocular normotensive cynomolgus monkeys."3.69Effect of daily topical ethacrynic acid on aqueous humor dynamics in monkeys. ( Croft, MA; Kaufman, PL, 1995)
"We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma."3.68The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992)
"We evaluated the effect of topical ethacrynic acid on rabbit and monkey intraocular pressure."3.68Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys. ( Epstein, DL; Epstein, MP; Schroeder, A; Tingey, DP, 1992)
"Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma."1.35Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. ( Arnold, JJ; Challa, P; Chen, X; Choksi, Y; Epstein, DL; Hatten, J; Shimazaki, A; Toone, EJ, 2009)
" Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0."1.34Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007)
"Intraocular pressure was continuously recorded for up to two weeks after exposure."1.29Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture. ( Johnson, DH; Tschumper, RC, 1993)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's9 (56.25)18.2507
2000's6 (37.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arnold, JJ1
Choksi, Y1
Chen, X1
Shimazaki, A4
Hatten, J1
Toone, EJ1
Epstein, DL8
Challa, P2
Wang, Y1
Yuan, F1
Ichikawa, M2
Rao, PV3
Kirihara, T2
Konomi, K1
Hara, H1
Franse-Carman, L1
Alvarado, JA1
Tajima, H1
Matsugi, T1
Croft, MA2
Hubbard, WC1
Kaufman, PL2
Wang, RF1
Podos, SM1
Serle, JB1
Lee, PY1
Neufeld, AH1
Deschenes, R1
Johnson, DH1
Tschumper, RC1
Toczołowski, J1
Woźniak, D1
Searles, RV1
Johnson, M1
Shikher, V1
Balaban, CD1
Severs, WB1
Deshpande, G1
Schoenwald, RD1
Barfknecht, CF1
Duffel, MW1
Melamed, S1
Kotas-Neumann, R1
Barak, A1
Tingey, DP2
Schroeder, A2
Epstein, MP1
Ozment, RR1
Peczon, JD1
Grant, WM1

Other Studies

16 other studies available for ethacrynic acid and Intraocular Pressure

ArticleYear
Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2009, Volume: 25, Issue:3

    Topics: Administration, Topical; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cin

2009
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
    Biomaterials, 2004, Volume: 25, Issue:18

    Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni

2004
Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:7

    Topics: Animals; Cats; Cinnamates; Cornea; Diuretics; Dose-Response Relationship, Drug; Ethacrynic Acid; Int

2004
Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:12

    Topics: Actins; Aqueous Humor; Cell Culture Techniques; Cell Shape; Cell Survival; Cinnamates; Cytoskeleton;

2005
Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8

    Topics: Administration, Topical; Animals; Cats; Cinnamates; Corneal Diseases; Diuretics; Epithelium, Corneal

2007
Effect of ethacrynic acid on aqueous outflow dynamics in monkeys.
    Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:3

    Topics: Animals; Aqueous Humor; Dose-Response Relationship, Drug; Ethacrynic Acid; Female; Intraocular Press

1994
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1994, Volume: 112, Issue:3

    Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic A

1994
Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture.
    Current eye research, 1993, Volume: 12, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Culture Media; Ethacrynic Acid; Humans; Intraocular P

1993
Effect of daily topical ethacrynic acid on aqueous humor dynamics in monkeys.
    Current eye research, 1995, Volume: 14, Issue:9

    Topics: Administration, Topical; Animals; Aqueous Humor; Ethacrynic Acid; Eye; Female; Intraocular Pressure;

1995
[Studies of changes in filtration angle after experimental administration of ethacrynic acid into the anterior chamber].
    Klinika oczna, 1996, Volume: 98, Issue:2

    Topics: Animals; Anterior Chamber; Ethacrynic Acid; Intraocular Pressure; Rabbits; Trabecular Meshwork

1996
Effects of ethacrynic acid on intraocular pressure of anesthetized rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 220, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Ethacrynic Acid; Infusion Pumps; Intraocular Pressure; Male; Mo

1999
In vitro and ex vivo hydrolysis rates of ethacrynate esters and their relationship to intraocular pressure in the rabbit eye.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:6

    Topics: Administration, Topical; Animals; Anterior Eye Segment; Aqueous Humor; Chromatography, High Pressure

2000
The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma.
    American journal of ophthalmology, 1992, May-15, Volume: 113, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Endothelium, Corneal; Ethacrynic Acid;

1992
Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:5

    Topics: Acetylcysteine; Animals; Corneal Edema; Dose-Response Relationship, Drug; Drug Combinations; Ethacry

1992
The effect of intracameral ethacrynic acid on the intraocular pressure of living monkeys.
    American journal of ophthalmology, 1992, Jun-15, Volume: 113, Issue:6

    Topics: Animals; Anterior Eye Segment; Corneal Edema; Ethacrynic Acid; Injections; Intraocular Pressure; Mac

1992
Diuretic drugs in glaucoma.
    American journal of ophthalmology, 1968, Volume: 66, Issue:4

    Topics: Acetazolamide; Adult; Bendroflumethiazide; Chlormerodrin; Diuretics; Ethacrynic Acid; Furosemide; Gl

1968