ethacrynic acid has been researched along with Injury, Ischemia-Reperfusion in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter in neuronal membranes, would prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats." | 3.70 | Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats. ( Guo, SZ; Iyer, VG; Reid, KH, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagy, T | 1 |
| Kovács, V | 1 |
| Hardi, P | 1 |
| Veres, TG | 1 |
| Takács, I | 1 |
| Jancsó, G | 1 |
| Sinay, L | 1 |
| Fazekas, G | 1 |
| Pintér, Ö | 1 |
| Arató, E | 1 |
| Reid, KH | 1 |
| Guo, SZ | 1 |
| Iyer, VG | 1 |
2 other studies available for ethacrynic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Inhibition of Glutathione S-Transferase by Ethacrynic Acid Augments Ischemia-Reperfusion Damage and Apoptosis and Attenuates the Positive Effect of Ischemic Postconditioning in a Bilateral Acute Hindlimb Ischemia Rat Model.
Topics: Acute Disease; Animals; Apoptosis; Ethacrynic Acid; Glutathione; Glutathione Transferase; Hindlimb; | 2015 |
Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Brain; Bumetanide; Carrier Proteins; Diuretics; Ep | 2000 |