ethacrynic acid has been researched along with Inflammation in 6 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen." | 2.39 | Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996) |
| "Ethacrynic acid has been used as a safe and effective diuretic for more than 30 years." | 1.33 | Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway. ( Delude, RL; Englert, JA; Fink, MP; Han, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Nagy, T | 1 |
| Kovács, V | 1 |
| Hardi, P | 1 |
| Veres, TG | 1 |
| Takács, I | 1 |
| Jancsó, G | 1 |
| Sinay, L | 1 |
| Fazekas, G | 1 |
| Pintér, Ö | 1 |
| Arató, E | 1 |
| Han, Y | 1 |
| Englert, JA | 1 |
| Delude, RL | 1 |
| Fink, MP | 1 |
| Mauleón, D | 1 |
| Artigas, R | 1 |
| García, ML | 1 |
| Carganico, G | 1 |
| Paparella, MM | 1 |
| Oronsky, AL | 1 |
| Triner, L | 1 |
| Steinsland, OS | 1 |
| Nahas, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ethacrynic acid and Inflammation
| Article | Year |
|---|---|
Preclinical and clinical development of dexketoprofen.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor | 1996 |
5 other studies available for ethacrynic acid and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Inhibition of Glutathione S-Transferase by Ethacrynic Acid Augments Ischemia-Reperfusion Damage and Apoptosis and Attenuates the Positive Effect of Ischemic Postconditioning in a Bilateral Acute Hindlimb Ischemia Rat Model.
Topics: Acute Disease; Animals; Apoptosis; Ethacrynic Acid; Glutathione; Glutathione Transferase; Hindlimb; | 2015 |
Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Cell-F | 2005 |
The dizzy patient.
Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inf | 1972 |
Effect of sulphydryl binding compounds on the inflammatory process.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Ethacrynic Acid; Ethylmaleimide; Granuloma; Inflam | 1969 |