ethacrynic acid has been researched along with Hypertension in 76 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Excerpt | Relevance | Reference |
---|---|---|
"In a double-blind study, 28 patients having mild to moderate essential hypertension were randomly assigned to a 6-week regimen of ticrynafen, hydrochlorothiazide, or placebo." | 9.04 | Ticrynafen and hydrochlorothiazide in hypertension. ( Beg, M; Okun, R, 1978) |
"In a double-blind study, 28 patients having mild to moderate essential hypertension were randomly assigned to a 6-week regimen of ticrynafen, hydrochlorothiazide, or placebo." | 5.04 | Ticrynafen and hydrochlorothiazide in hypertension. ( Beg, M; Okun, R, 1978) |
"In 572 patients with hypertension a long-term therapy with alpha-methyldopa (Dopegyt) was carried out and this preparation was found to be highly effective." | 3.65 | [Long-range therapy of hypertension]. ( Radó, J; Szám, I; Takó, J, 1976) |
"Hypertension is a major risk factor for cardiovascular disease, but control of hypertension remains inadequate, often because of poor patient adherence to prescribed medical regimens that are viewed as poorly tolerated and expensive." | 2.47 | Older blood pressure medications-do they still have a place? ( Black, HR; Slim, HB; Thompson, PD, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 75 (98.68) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (1.32) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Slim, HB | 1 |
Black, HR | 2 |
Thompson, PD | 1 |
DOLLERY, CT | 3 |
PARRY, EH | 1 |
YOUNG, DS | 1 |
SCHROEDER, G | 1 |
SANNERSTEDT, R | 2 |
WERKOE, L | 1 |
CANNON, PJ | 2 |
HEINEMANN, HO | 1 |
STASON, WB | 1 |
LARAGH, JH | 3 |
CONWAY, J | 1 |
LEONETTI, G | 2 |
BREST, AN | 1 |
ONESTI, G | 2 |
SELLER, R | 1 |
RAMIREZ, O | 1 |
HEIDER, C | 1 |
MOYER, JH | 1 |
Davidov, M | 1 |
Kakaviatos, N | 1 |
Finnerty, FA | 3 |
Bufalari, A | 1 |
Meloni, G | 1 |
Wedler, B | 1 |
Wüstenberg, PW | 1 |
Naumann, G | 1 |
Swartz, C | 2 |
Kim, KE | 2 |
Riddiough, MA | 1 |
Okun, R | 1 |
Beg, M | 1 |
Steiner, RW | 1 |
Blantz, RC | 1 |
Gessler, U | 1 |
Zanchetti, A | 2 |
Stella, A | 1 |
Frohlich, ED | 1 |
Martinez, EW | 1 |
Werning, C | 1 |
Szám, I | 1 |
Radó, J | 1 |
Takó, J | 1 |
Canavese, JC | 1 |
Fabre, J | 1 |
Krumlovsky, FA | 1 |
del Greco, F | 1 |
Page, LB | 1 |
Yager, HM | 1 |
Sidd, JJ | 1 |
Hosking, MP | 1 |
Kohner, EM | 1 |
Lowy, C | 1 |
Schumer, B | 1 |
Guédon, J | 1 |
Suzuki, Y | 2 |
Ina, K | 2 |
Yamada, H | 1 |
Yamagami, I | 2 |
Murphy, GP | 1 |
Mirand, EA | 1 |
Johnston, GS | 1 |
Gibbons, RP | 1 |
Schirmer, HK | 1 |
Scott, WW | 1 |
Gardner, JD | 1 |
Lapey, A | 1 |
Simopoulos, P | 1 |
Bravo, EL | 2 |
Kennedy, AC | 1 |
Pohl, JE | 1 |
Swales, JD | 1 |
Thurston, H | 1 |
Mashaly, M | 1 |
el-Ebrashy, N | 1 |
Higazi, AM | 1 |
el-Din Moustafa, S | 1 |
Abul-Einen, M | 1 |
Takasu, T | 1 |
Frazier, HS | 1 |
Yager, H | 1 |
Leemhuis, MP | 1 |
Struyvenberg, A | 1 |
Fishback, DB | 1 |
Dustan, HR | 1 |
Tarazi, RC | 1 |
Farel, H | 1 |
Fritel, D | 1 |
Milliez, P | 1 |
Kirkendall, WM | 2 |
Stein, JH | 1 |
Tucker, RM | 1 |
Hunt, JC | 1 |
Hutchison, JC | 1 |
Ikeda, T | 1 |
Gifford, RW | 1 |
Jahrmärker, H | 1 |
Anderton, JL | 1 |
Kincaid-Smith, P | 1 |
Himathongkam, T | 1 |
Ratner, NA | 1 |
Glezer, GA | 1 |
Groznovich, NA | 1 |
Moskalenko, NP | 1 |
Perez-Stable, EC | 1 |
Munoz, JT | 1 |
Shapiro, AP | 1 |
Scheib, ET | 1 |
Neuvonen, PJ | 1 |
Meneuvonen, PJ | 1 |
Karppanen, H | 1 |
Grollman, A | 1 |
Krakoff, LR | 1 |
Goodwin, FJ | 1 |
Baer, L | 1 |
Torres, M | 1 |
Torday, Z | 1 |
Abel, A | 1 |
Filipecki, S | 1 |
Chodakowska, J | 1 |
Bar-Andziak, E | 1 |
Müscher, CH | 1 |
Felman, D | 1 |
Theoleyre, J | 1 |
Dupoizat, H | 1 |
Grazi, S | 1 |
Romano, S | 1 |
Polese, A | 1 |
Andersen, OO | 2 |
Persson, I | 2 |
Russell, RP | 1 |
Lindeman, RD | 1 |
Prescott, LF | 1 |
Quellhorst, E | 1 |
Scheler, F | 1 |
Freis, ED | 1 |
Garde, K | 1 |
Lindahl, A | 1 |
Heimsoth, V | 1 |
Hartmann, F | 1 |
Nash, HL | 1 |
Fitz, AE | 1 |
Wilson, WR | 1 |
Kioschos, JM | 1 |
Bojs, G | 1 |
Lundvall, O | 2 |
Ames, RP | 1 |
Alestig, K | 1 |
10 reviews available for ethacrynic acid and Hypertension
Article | Year |
---|---|
Older blood pressure medications-do they still have a place?
Topics: Antihypertensive Agents; Chlorthalidone; Clonidine; Diuretics; Ethacrynic Acid; Guanethidine; Humans | 2011 |
Preventing, detecting and managing adverse reactions of antihypertensive agents in the ambulant patient with essential hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Drug Interactions; Ethacrynic Acid | 1977 |
Neural control of renin release.
Topics: Animals; Cats; Dogs; Electric Stimulation; Ethacrynic Acid; Furosemide; Humans; Hypertension; Hypoth | 1975 |
The clinical use of diuretics. 2.
Topics: Acute Kidney Injury; Diabetes Insipidus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertensio | 1973 |
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
Clinical pharmacology of furosemide and ethacrynic acid.
Topics: Anuria; Diabetes Insipidus; Edema; Ethacrynic Acid; Furosemide; Heart Failure; Hemodynamics; Humans; | 1968 |
Recent advances in the medical and surgical treatment of hypertension.
Topics: Adrenocortical Hyperfunction; Antihypertensive Agents; Diet, Sodium-Restricted; Diuretics; Ethacryni | 1968 |
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
[When and which diuretics? General and specific indications for diuretic therapy].
Topics: Acid-Base Equilibrium; Brain Edema; Diuresis; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans; | 1971 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
8 trials available for ethacrynic acid and Hypertension
Article | Year |
---|---|
Ticrynafen and hydrochlorothiazide in hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethacrynic Acid; Humans; Hydro | 1978 |
Effect of diuretic therapy on glucose tolerance in hypertensive patients.
Topics: Age Factors; Blood Glucose; Body Weight; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Fasting; Fat | 1971 |
[Clinical study of a new diuretic: ethacrynic acid (M.K. 595)].
Topics: Adult; Aged; Clinical Trials as Topic; Ethacrynic Acid; Female; Heart Failure; Humans; Hypertension; | 1965 |
Ethacrynic acid. A non-diabetogenic diuretic.
Topics: Aged; Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus; Ethacrynic Acid; Female; | 1969 |
Ethacrynic acid alone and in combination with methyldopa in the management of mild hypertension. A report of 23 patients.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diarrhea; Drug Synergism; Ethacrynic Acid; Fe | 1970 |
Comparison of ethacrynic acid and hydrochlorothiazide in hypertension.
Topics: Aged; Ethacrynic Acid; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Middle Age | 1971 |
Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid.
Topics: Aged; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Cortisone; Diabetes Mellitus; Ethacryn | 1968 |
Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide.
Topics: Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Blood Urea Nitroge | 1968 |
58 other studies available for ethacrynic acid and Hypertension
Article | Year |
---|---|
DIURETIC AND HYPOTENSIVE PROPERTIES OF ETHACRYNIC ACID: A COMPARISON WITH HYDROCHLOROTHIAZIDE.
Topics: Biomedical Research; Blood Pressure; Blood Pressure Determination; Chlorides; Diuretics; Ethacrynic | 1964 |
CLINICAL EXPERIENCES WITH ETHACRYNIC ACID, A NEW NON-THIAZIDE SALURETIC AGENT (MK-595).
Topics: Aneurysm; Arteriosclerosis; Biomedical Research; Blood; Body Weight; Creatine; Creatinine; Diabetes | 1964 |
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors; | 1965 |
ETHACRYNIC ACID.
Topics: Agranulocytosis; Diarrhea; Diuretics; Drug Therapy; Edema; Ethacrynic Acid; Hypertension; Nausea; Ph | 1965 |
HYPOTENSIVE EFFECT OF ETHACRYNIC ACID.
Topics: Biomedical Research; Blood Chemical Analysis; Diet, Sodium-Restricted; Diuretics; Drug Therapy; Etha | 1965 |
PHARMACODYNAMIC EFFECTS OF A NEW DIURETIC DRUG, ETHACRYNIC ACID.
Topics: Biomedical Research; Blood Pressure; Blood Pressure Determination; Chlorides; Diuresis; Diuretics; D | 1965 |
Antihypertensive properties of furosemide.
Topics: Alkaline Phosphatase; Blood Proteins; Blood Urea Nitrogen; Blood Volume; Body Weight; Electrolytes; | 1967 |
[The behavior of uricemia during treatment with spironolactone and with other diuretics].
Topics: Acetazolamide; Adolescent; Adult; Aged; Chlorthalidone; Clopamide; Diuretics; Ethacrynic Acid; Femal | 1967 |
[Treatment of hypertonus in diabetes mellitus].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diabetes Complications; Diabetes Mellitus; Eth | 1975 |
Management of hypertension.
Topics: Adrenergic alpha-Antagonists; Benzothiadiazines; Clonidine; Diuretics; Ethacrynic Acid; Furosemide; | 1977 |
Treatment of complicated hypertension.
Topics: Acute Disease; Cerebral Hemorrhage; Cerebrovascular Disorders; Chronic Disease; Coronary Disease; Di | 1977 |
The use of diuretics in nonedematous conditions.
Topics: Acute Kidney Injury; Benzothiadiazines; Calcium; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hyp | 1979 |
[Diuretics].
Topics: Diuretics; Edema; Ethacrynic Acid; Furosemide; Glomerular Filtration Rate; Hearing Disorders; Humans | 1978 |
Editorial: Use and abuse of diuretics.
Topics: Benzothiadiazines; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart Failure; Humans; Hypertensio | 1975 |
Choosing a diuretic in hypertension.
Topics: Benzothiadiazines; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertension; Sodium Chloride Sym | 1977 |
[The therapy of edematous diseases].
Topics: Antihypertensive Agents; Bed Rest; Diabetes Insipidus; Diuretics; Diuretics, Osmotic; Edema; Ethacry | 1977 |
[Long-range therapy of hypertension].
Topics: Drug Administration Schedule; Drug Therapy, Combination; Ethacrynic Acid; Humans; Hypertension; Meth | 1976 |
[The diuretics in the treatment of arteriol hypertension].
Topics: Amiloride; Benzothiadiazines; Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypert | 1976 |
Diuretic agents. Mechanisms of action and clinical uses.
Topics: Acute Kidney Injury; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Diabetes Insipidus; Diuretics | 1976 |
Drugs in the management of hypertension. Part I.
Topics: Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertension; Spironolactone | 1976 |
Ethacrynic acid interferes with vasodilators.
Topics: Drug Interactions; Ethacrynic Acid; Humans; Hypertension; Vasodilator Agents | 1986 |
Diuretics in the treatment of arterial hypertension.
Topics: Benzothiadiazines; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertension; Sodium Chloride Sym | 1972 |
[Pharmacological studies on diuretics. 7. Diuretic activity and mechanism of action of a new thiazide diuretic, penfluzide].
Topics: Adenosine Triphosphatases; Alkalosis; Animals; Antihypertensive Agents; Bendroflumethiazide; Blood P | 1973 |
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El | 1968 |
Abnormal membrane sodium transport in Liddle's syndrome.
Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Biological Transport; Cell Membrane; Child; Erythroc | 1971 |
Treatment of hypertensive crisis.
Topics: Adrenergic alpha-Antagonists; Diazoxide; Ethacrynic Acid; Ferricyanides; Furosemide; Humans; Hydrala | 1970 |
Editorial: Frusemide.
Topics: Ethacrynic Acid; Furosemide; Hypertension; Kidney Failure, Chronic; Loop of Henle; Potassium; Propra | 1974 |
Renal effects of diazoxide and frusemide and interrelationships.
Topics: Creatinine; Diazoxide; Diuretics; Ethacrynic Acid; Female; Follow-Up Studies; Furans; Furosemide; Gl | 1974 |
Dietary sodium restriction and natriuresis in management of hypertension.
Topics: Adult; Aged; Benzothiadiazines; Diet, Sodium-Restricted; Diuretics; Ethacrynic Acid; Female; Furosem | 1974 |
[My prescription of diuretics].
Topics: Acute Kidney Injury; Benzothiadiazines; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans; Hyper | 1974 |
Problems in therapy for the hypertensive patient.
Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic | 1973 |
How to treat arterial hypertension.
Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Cooperative Behavior; Diazoxide; Diuretics; | 1973 |
Diazoxide (hyperstat).
Topics: Blood Pressure; Diazoxide; Ethacrynic Acid; Female; Furosemide; Humans; Hypertension; Hypertension, | 1973 |
Fluorescein circulation time and the treatment of hypertension in the aged.
Topics: Adult; Age Factors; Aged; Blood Circulation Time; Blood Pressure; Carbamates; Ethacrynic Acid; Femal | 1973 |
Drugs used in the treatment of hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Ethacrynic Acid; Fer | 1973 |
[Pharmacological studies on diuretics. 6. Actions of various diuretics on experimental nephrotic rats].
Topics: Acetazolamide; Aminophylline; Animals; Diuresis; Diuretics; Ethacrynic Acid; Furosemide; Glycosides; | 1973 |
Diuretic and diet treatment of hypertension.
Topics: Benzothiadiazines; Blood Volume; Chlorthalidone; Creatinine; Diet, Sodium-Restricted; Diuretics; Eth | 1974 |
Hypertensive emergencies.
Topics: Diazoxide; Emergencies; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension | 1972 |
[Diuretic and hypotensive action of uregite (ethacrynic acid)].
Topics: Amyloidosis; Arteries; Blood Pressure; Diuresis; Ethacrynic Acid; Familial Mediterranean Fever; Glom | 1971 |
Influence of diuretics and diazoxide on ions and vascular reactivity in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Diazoxide; Ethacrynic Acid; Furosemide; Hematocrit; Hydrochlorothi | 1971 |
Effects of hydrochlorothiazide, furosemide and ethacrynic acid on pinealectomy-induced hypertension in rats.
Topics: Aldosterone; Animals; Blood Pressure; Ethacrynic Acid; Furosemide; Hydrochlorothiazide; Hypertension | 1971 |
Hypertension in the opossum Didelphis virginiana.
Topics: Age Factors; Animals; Animals, Newborn; Blood Vessels; Cortisone; Desoxycorticosterone; Ethacrynic A | 1970 |
The role of renin in the exaggerated natriuresis of hypertension.
Topics: Adult; Aldosterone; Ethacrynic Acid; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyperal | 1970 |
Clinical observations concerning Uregyt, a Hungarian diuretic preparation of ethacrinic acid.
Topics: Adult; Aged; Edema; Ethacrynic Acid; Female; Humans; Hypertension; Male; Middle Aged | 1970 |
[Results of treatment with intravenous ethacrynic acid injections of patients with acute left ventricular circulatory failure].
Topics: Acute Disease; Adult; Aged; Arteriosclerosis; Diuresis; Ethacrynic Acid; Female; Heart Defects, Cong | 1971 |
[Experiences in the treatment of cardiac insufficiency with the sulfonamide-free diuretic Hydromedin (ethacrynic acid) in ambulatory practice].
Topics: Ambulatory Care; Cardiovascular Diseases; Diet Therapy; Digitalis Glycosides; Edema; Ethacrynic Acid | 1967 |
[Trial of ethacrynic acid in treatment of excessive weight gain and arterial hypertension in pregnancy].
Topics: Adult; Arteries; Body Weight; Diabetes Mellitus; Ethacrynic Acid; Female; Humans; Hypertension; Infa | 1967 |
[Hypotensive effect of the association of hydrochlorothiazide and ethacrynic acid. Study of the relations between sodium depletion and blood pressure levels].
Topics: Diet, Sodium-Restricted; Ethacrynic Acid; Humans; Hydrochlorothiazide; Hypertension | 1967 |
[Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid].
Topics: Aged; Carbohydrate Metabolism; Chlorthalidone; Diabetes Mellitus; Ethacrynic Acid; Female; Humans; H | 1968 |
[Objectives and methods in therapy of essential arterial hypertension].
Topics: Antihypertensive Agents; Chlorthalidone; Diuretics; Ethacrynic Acid; Guanethidine; Humans; Hydralazi | 1968 |
[On the management of renal acidosis using sodium bicarbonate and ethacrynic acid].
Topics: Acidosis, Renal Tubular; Acute Kidney Injury; Adult; Bicarbonates; Blood Pressure; Body Weight; Etha | 1969 |
Hypertensive crisis.
Topics: Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Reserpine; | 1969 |
[Ethacrynic acid and furosemide used in the treatment of hypertension as compared with chlorthalidone].
Topics: Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertension | 1965 |
[Studies on uric acid metabolism disorders following administration of saluretics].
Topics: Chlorothiazide; Chlorthalidone; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Hydroflume | 1965 |
Cardiorenal hemodynamic effects of ethacrynic acid.
Topics: Chlorothiazide; Diabetes Insipidus; Edema; Electrolytes; Ethacrynic Acid; Heart; Heart Failure; Hear | 1966 |
Effects of ethacrynic acid on renal function in man.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Ethacrynic Acid; Female; Glomerular Filtration Rate; Hea | 1966 |
Relation between potassium balance and aldosterone secretion in normal subjects and in patients with hypertensive or renal tubular disease.
Topics: Acidosis, Renal Tubular; Adrenal Gland Neoplasms; Adult; Aldosterone; Ethacrynic Acid; Female; Human | 1966 |
[Ethacrynic acid in the treatment of arterial hypertension].
Topics: Adult; Ethacrynic Acid; Female; Humans; Hypertension; Male; Middle Aged | 1966 |