ethacrynic acid has been researched along with Hyperemia in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma." | 1.35 | Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. ( Arnold, JJ; Challa, P; Chen, X; Choksi, Y; Epstein, DL; Hatten, J; Shimazaki, A; Toone, EJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnold, JJ | 1 |
| Choksi, Y | 1 |
| Chen, X | 1 |
| Shimazaki, A | 1 |
| Hatten, J | 1 |
| Toone, EJ | 1 |
| Epstein, DL | 1 |
| Challa, P | 1 |
| Ogilvie, RI | 1 |
2 other studies available for ethacrynic acid and Hyperemia
| Article | Year |
|---|---|
Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
Topics: Administration, Topical; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cin | 2009 |
Effect of ethacrynic acid on hindlimb vascular resistance of anephric dogs.
Topics: Acetylcholine; Adenosine Triphosphatases; Animals; Blood Pressure; Dogs; Ethacrynic Acid; Female; Hi | 1971 |