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ethacrynic acid and Hyperemia

ethacrynic acid has been researched along with Hyperemia in 2 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research Excerpts

ExcerptRelevanceReference
"Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma."1.35Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. ( Arnold, JJ; Challa, P; Chen, X; Choksi, Y; Epstein, DL; Hatten, J; Shimazaki, A; Toone, EJ, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arnold, JJ1
Choksi, Y1
Chen, X1
Shimazaki, A1
Hatten, J1
Toone, EJ1
Epstein, DL1
Challa, P1
Ogilvie, RI1

Other Studies

2 other studies available for ethacrynic acid and Hyperemia

ArticleYear
Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2009, Volume: 25, Issue:3

    Topics: Administration, Topical; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cin

2009
Effect of ethacrynic acid on hindlimb vascular resistance of anephric dogs.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:2

    Topics: Acetylcholine; Adenosine Triphosphatases; Animals; Blood Pressure; Dogs; Ethacrynic Acid; Female; Hi

1971