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ethacrynic acid and Hepatocellular Carcinoma

ethacrynic acid has been researched along with Hepatocellular Carcinoma in 4 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Research Excerpts

ExcerptRelevanceReference
" Each compound was evaluated for cytotoxicity to construct dosing regimens in transfection studies."1.30Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. ( Kroll, DJ; Luckey, SW; Petersen, DR; Tjalkens, RB, 1998)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, WY1
Cheung, CC1
Liu, KW1
Fung, KP1
Wong, J1
Lai, PB1
Yeung, JH1
Anderson, K1
Andrews, R1
Yin, L1
McLeod, R1
MacDonald, C1
Hayes, JD1
Grant, MH1
Tjalkens, RB1
Luckey, SW1
Kroll, DJ1
Petersen, DR1
Zhang, K1
Chew, M1
Yang, EB1
Wong, KP1
Mack, P1

Other Studies

4 other studies available for ethacrynic acid and Hepatocellular Carcinoma

ArticleYear
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
    Journal of natural products, 2010, May-28, Volume: 73, Issue:5

    Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxor

2010
Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines.
    Human & experimental toxicology, 1998, Volume: 17, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Dinitrochlorobenzene; Ethacrynic Acid;

1998
Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element.
    Archives of biochemistry and biophysics, 1998, Nov-01, Volume: 359, Issue:1

    Topics: Acrolein; Aldehydes; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carcinoma, Hepato

1998
Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.
    Molecular pharmacology, 2001, Volume: 59, Issue:4

    Topics: Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Carrier Proteins; Cisplatin

2001