ethacrynic acid has been researched along with Hepatocellular Carcinoma in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Each compound was evaluated for cytotoxicity to construct dosing regimens in transfection studies." | 1.30 | Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. ( Kroll, DJ; Luckey, SW; Petersen, DR; Tjalkens, RB, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, WY | 1 |
| Cheung, CC | 1 |
| Liu, KW | 1 |
| Fung, KP | 1 |
| Wong, J | 1 |
| Lai, PB | 1 |
| Yeung, JH | 1 |
| Anderson, K | 1 |
| Andrews, R | 1 |
| Yin, L | 1 |
| McLeod, R | 1 |
| MacDonald, C | 1 |
| Hayes, JD | 1 |
| Grant, MH | 1 |
| Tjalkens, RB | 1 |
| Luckey, SW | 1 |
| Kroll, DJ | 1 |
| Petersen, DR | 1 |
| Zhang, K | 1 |
| Chew, M | 1 |
| Yang, EB | 1 |
| Wong, KP | 1 |
| Mack, P | 1 |
4 other studies available for ethacrynic acid and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxor | 2010 |
Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Dinitrochlorobenzene; Ethacrynic Acid; | 1998 |
Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element.
Topics: Acrolein; Aldehydes; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carcinoma, Hepato | 1998 |
Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.
Topics: Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Carrier Proteins; Cisplatin | 2001 |