ethacrynic acid has been researched along with Hearing Loss in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Hearing Loss: A general term for the complete or partial loss of the ability to hear from one or both ears.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chinchillas deprived of food for 48 h prior to the administration of a combined dose of ethacrynic acid (10 mg/kg) and kanamycin (100 mg/kg) suffered a profound hearing loss." | 3.67 | Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics. ( Hoffman, DW; Jones, KL; Rybak, LP; Whitworth, CA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Ding, DL | 1 |
| Jiang, HY | 1 |
| Wu, XW | 1 |
| Salvi, R | 1 |
| Sun, H | 1 |
| Kashio, A | 1 |
| Sakamoto, T | 1 |
| Suzukawa, K | 1 |
| Asoh, S | 1 |
| Ohta, S | 1 |
| Yamasoba, T | 1 |
| Gallagher, KL | 1 |
| Jones, JK | 1 |
| Hoffman, DW | 1 |
| Whitworth, CA | 1 |
| Jones, KL | 1 |
| Rybak, LP | 1 |
4 other studies available for ethacrynic acid and Hearing Loss
| Article | Year |
|---|---|
Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats.
Topics: Animals; Anti-Bacterial Agents; Deafness; Ear, Inner; Ethacrynic Acid; Hearing Loss; Kanamycin; Rats | 2011 |
A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo.
Topics: Aminoglycosides; Analysis of Variance; Animals; bcl-X Protein; Cell Death; Cochlea; Ethacrynic Acid; | 2007 |
Furosemide-induced ototoxicity.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Ethacrynic Acid; Female; Furosemide; Hearing Loss; Humans; | 1979 |
Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics.
Topics: Animals; Chinchilla; Cochlea; Deafness; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory | 1987 |