ethacrynic acid has been researched along with Hearing Loss, Sensorineural in 13 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosage or duration of aminoglycosides use did not relate to SNHL." | 2.72 | Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure. ( Cheung, PY; Etches, PC; Peliowski, A; Robertson, CM; Tyebkhan, JM, 2006) |
| " In the chinchilla, co-administration of GM and EA can produce hair cell lesions ranging from a small loss of outer hair cells (OHCs) in the base of the cochlea to complete destruction of all hair cells, depending on dosing parameters." | 1.32 | Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla. ( Ding, D; Jiang, H; McFadden, SL; Salvi, RJ, 2004) |
| "Gentamicin sulfate was given as a single injection (100 mg/kg of body weight subcutaneously), followed 90 minutes later by varying concentrations of ethacrynic acid intravenously." | 1.29 | A sensitive animal model to assess acute and chronic ototoxic effects. ( Lautermann, J; Schacht, J, 1996) |
| " The dosage range of ethacrynic acid during which the interaction occurs is very narrow, while the dose range of kanamycin is very large." | 1.26 | Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid. ( Brown, RT; Brummett, RE; Himes, DL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McFadden, SL | 1 |
| Ding, D | 1 |
| Jiang, H | 1 |
| Salvi, RJ | 1 |
| Izumikawa, M | 1 |
| Minoda, R | 1 |
| Kawamoto, K | 1 |
| Abrashkin, KA | 1 |
| Swiderski, DL | 1 |
| Dolan, DF | 1 |
| Brough, DE | 1 |
| Raphael, Y | 1 |
| Robertson, CM | 1 |
| Tyebkhan, JM | 1 |
| Peliowski, A | 1 |
| Etches, PC | 1 |
| Cheung, PY | 1 |
| Humes, LE | 1 |
| Lerner, SA | 1 |
| Matz, GJ | 1 |
| Komune, S | 1 |
| Snow, JB | 1 |
| Beaugard, ME | 1 |
| Shepherd, RK | 1 |
| Matsushima, J | 1 |
| Martin, RL | 1 |
| Clark, GM | 1 |
| Lautermann, J | 1 |
| Schacht, J | 1 |
| Brummett, RE | 1 |
| Brown, RT | 1 |
| Himes, DL | 1 |
| Marlowe, FI | 1 |
| Aran, JM | 1 |
| Portmann, M | 1 |
| Dong, W | 1 |
1 trial available for ethacrynic acid and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure.
Topics: Amikacin; Aminoglycosides; Anti-Infective Agents; Audiometry, Pure-Tone; Auditory Threshold; Diureti | 2006 |
12 other studies available for ethacrynic acid and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla.
Topics: Acetylcholinesterase; Action Potentials; Animals; Cell Count; Cell Death; Chinchilla; Cochlear Micro | 2004 |
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals.
Topics: Adenoviridae; Animals; Cochlea; DNA-Binding Proteins; Ethacrynic Acid; Gene Expression Regulation, D | 2005 |
Noise-induced hearing loss as influenced by other agents and by some physical characteristics of the individual.
Topics: Acoustic Stimulation; Age Factors; Animals; Ethacrynic Acid; Eye Color; Furosemide; Hearing Loss, No | 1984 |
Aminoglycoside ototoxicity.
Topics: Adult; Aminoglycosides; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Ethac | 1980 |
Potentiating effects of cisplatin and ethacrynic acid in ototoxicity.
Topics: Animals; Audiometry; Cisplatin; Cochlea; Cochlear Microphonic Potentials; Ear, External; Ethacrynic | 1981 |
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid.
Topics: Animals; Chloramphenicol; Ethacrynic Acid; Guinea Pigs; Hearing Loss, Sensorineural; Kanamycin | 1981 |
Cochlear pathology following chronic electrical stimulation of the auditory nerve: II. Deafened kittens.
Topics: Analysis of Variance; Animals; Bone Development; Cats; Cell Count; Cell Survival; Cochlea; Cochlear | 1994 |
A sensitive animal model to assess acute and chronic ototoxic effects.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Auditory Threshold; Diet, Protein-Restricted; Disease | 1996 |
Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid.
Topics: Animals; Cochlea; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Ethacrynic Ac | 1979 |
Ototoxic agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Aspirin; Child; Drug-Related Side Effects and Adver | 1978 |
[Synergism between noise and ototoxic drugs: new experimental data].
Topics: Animals; Ethacrynic Acid; Gentamicins; Guinea Pigs; Hearing; Hearing Loss, Sensorineural; Noise | 1990 |
[An electrophysiological study of the oxytocin antagonism on the ototoxic effects of ethacrynic acid].
Topics: Action Potentials; Animals; Cochlear Microphonic Potentials; Electrophysiology; Ethacrynic Acid; Fem | 1988 |