ethacrynic acid has been researched along with HbS Disease in 3 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Forrester, TE | 1 |
| Alleyne, GA | 1 |
| Orringer, EP | 1 |
| Blythe, DS | 1 |
| Whitney, JA | 1 |
| Brockenbrough, S | 1 |
| Abraham, DJ | 1 |
| Knochel, JP | 1 |
3 other studies available for ethacrynic acid and HbS Disease
| Article | Year |
|---|---|
Excretion of salt and water by patients with sickle-cell anaemia: effect of a diuretic and solute diuresis.
Topics: Adult; Anemia, Sickle Cell; Diuresis; Ethacrynic Acid; Humans; Natriuresis; Sodium; Sodium Chloride | 1977 |
Physiologic and rheologic effects of the antisickling agent ethacrynic acid and its N-butylated derivative on normal and sickle erythrocytes.
Topics: Anemia, Sickle Cell; Antisickling Agents; Erythrocyte Membrane; Erythrocytes; Erythrocytes, Abnormal | 1992 |
Hematuria in sickle cell trait: the effect of intravenous administration of distilled water, urinary alkalinization, and diuresis.
Topics: Adult; Anemia, Sickle Cell; Bicarbonates; Blood Cell Count; Creatinine; Cystoscopy; Diuresis; Erythr | 1969 |