ethacrynic acid has been researched along with Granulocytic Leukemia in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combined apoptotic effects of ATO plus ethacrynic acid were tested in non-APL leukemia and lymphoma cell lines." | 7.78 | Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. ( Gabrilove, J; Jing, Y; Liu, C; Wang, R; Waxman, S; Xia, L; Zhao, G, 2012) |
| "The combined apoptotic effects of ATO plus ethacrynic acid were tested in non-APL leukemia and lymphoma cell lines." | 3.78 | Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. ( Gabrilove, J; Jing, Y; Liu, C; Wang, R; Waxman, S; Xia, L; Zhao, G, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, G | 1 |
| Wang, R | 2 |
| Wang, Y | 1 |
| Li, P | 1 |
| Zhao, G | 2 |
| Zhao, L | 1 |
| Jing, Y | 2 |
| Liu, C | 1 |
| Xia, L | 1 |
| Gabrilove, J | 1 |
| Waxman, S | 1 |
2 other studies available for ethacrynic acid and Granulocytic Leukemia
| Article | Year |
|---|---|
Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspas | 2013 |
Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Catalase; Cell Line, Tumor | 2012 |