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ethacrynic acid and Glaucoma

ethacrynic acid has been researched along with Glaucoma in 8 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."7.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma."7.69Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."3.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma."3.69Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994)
"Glaucoma is a potentially blinding disease."2.39Pharmacological advances in the treatment of glaucoma. ( Serle, JB, 1994)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's3 (37.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Y1
Challa, P1
Epstein, DL1
Yuan, F1
Cynkowska, G1
Cynkowski, T1
Al-Ghananeem, AM1
Al-Ghananeem, AA1
Guo, H1
Ashton, P1
Crooks, PA1
Serle, JB2
Wang, RF1
Podos, SM1
Lee, PY1
Neufeld, AH1
Deschenes, R1
Cotton, P1
Selchau, M1
Schmidt, P1
Peczon, JD1
Grant, WM1

Reviews

2 reviews available for ethacrynic acid and Glaucoma

ArticleYear
Pharmacological advances in the treatment of glaucoma.
    Drugs & aging, 1994, Volume: 5, Issue:3

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibit

1994
[Diuretics. 47].
    Pharmazeutische Praxis, 1970, Volume: 9

    Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen

1970

Other Studies

6 other studies available for ethacrynic acid and Glaucoma

ArticleYear
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
    Biomaterials, 2004, Volume: 25, Issue:18

    Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni

2004
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
    Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15

    Topics: Adrenergic beta-Antagonists; Atenolol; Ethacrynic Acid; Glaucoma; Polyethylene Glycols; Prodrugs; Ti

2005
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1994, Volume: 112, Issue:3

    Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic A

1994
Focus in glaucoma may change from keeping fluid out to letting fluid out.
    JAMA, 1993, Jun-02, Volume: 269, Issue:21

    Topics: Animals; Ethacrynic Acid; Glaucoma; Humans; Trabecular Meshwork

1993
[Diuresis and diuretics].
    Wiener klinische Wochenschrift, 1971, Jun-25, Volume: 83, Issue:25

    Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder

1971
Diuretic drugs in glaucoma.
    American journal of ophthalmology, 1968, Volume: 66, Issue:4

    Topics: Acetazolamide; Adult; Bendroflumethiazide; Chlormerodrin; Diuretics; Ethacrynic Acid; Furosemide; Gl

1968