ethacrynic acid has been researched along with Glaucoma in 8 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Excerpt | Relevance | Reference |
---|---|---|
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 7.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 7.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 3.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
"To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 3.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
"Glaucoma is a potentially blinding disease." | 2.39 | Pharmacological advances in the treatment of glaucoma. ( Serle, JB, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (37.50) | 18.7374 |
1990's | 3 (37.50) | 18.2507 |
2000's | 2 (25.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Wang, Y | 1 |
Challa, P | 1 |
Epstein, DL | 1 |
Yuan, F | 1 |
Cynkowska, G | 1 |
Cynkowski, T | 1 |
Al-Ghananeem, AM | 1 |
Al-Ghananeem, AA | 1 |
Guo, H | 1 |
Ashton, P | 1 |
Crooks, PA | 1 |
Serle, JB | 2 |
Wang, RF | 1 |
Podos, SM | 1 |
Lee, PY | 1 |
Neufeld, AH | 1 |
Deschenes, R | 1 |
Cotton, P | 1 |
Selchau, M | 1 |
Schmidt, P | 1 |
Peczon, JD | 1 |
Grant, WM | 1 |
2 reviews available for ethacrynic acid and Glaucoma
Article | Year |
---|---|
Pharmacological advances in the treatment of glaucoma.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibit | 1994 |
[Diuretics. 47].
Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen | 1970 |
6 other studies available for ethacrynic acid and Glaucoma
Article | Year |
---|---|
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni | 2004 |
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
Topics: Adrenergic beta-Antagonists; Atenolol; Ethacrynic Acid; Glaucoma; Polyethylene Glycols; Prodrugs; Ti | 2005 |
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic A | 1994 |
Focus in glaucoma may change from keeping fluid out to letting fluid out.
Topics: Animals; Ethacrynic Acid; Glaucoma; Humans; Trabecular Meshwork | 1993 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |
Diuretic drugs in glaucoma.
Topics: Acetazolamide; Adult; Bendroflumethiazide; Chlormerodrin; Diuretics; Ethacrynic Acid; Furosemide; Gl | 1968 |