ethacrynic acid has been researched along with Chronic Primary Open Angle Glaucoma in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma." | 7.68 | The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992) |
| "We studied the effect of ethacrynic acid on intraocular pressure in eyes with advanced open-angle glaucoma." | 3.68 | The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. ( Barak, A; Epstein, DL; Kotas-Neumann, R; Melamed, S, 1992) |
| "Ethacrynic acid (ECA) is a potential trabecular meshwork (TM) drug that has shown promising results in preclinical studies for treatment of primary open-angle glaucoma." | 1.37 | Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. ( Gonzalez, P; Lin, CW; Yuan, F, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, CW | 1 |
| Gonzalez, P | 1 |
| Yuan, F | 1 |
| Melamed, S | 1 |
| Kotas-Neumann, R | 1 |
| Barak, A | 1 |
| Epstein, DL | 1 |
2 other studies available for ethacrynic acid and Chronic Primary Open Angle Glaucoma
| Article | Year |
|---|---|
Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye.
Topics: Administration, Topical; Animals; Cell Survival; Chromatography, High Pressure Liquid; Cornea; Dose- | 2011 |
The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Endothelium, Corneal; Ethacrynic Acid; | 1992 |