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ethacrynic acid and Electrolytes

ethacrynic acid has been researched along with Electrolytes in 50 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

Excerpt	Relevance	Reference
" The influence of ethacrynic acid (EA), aspirin (two agents previously reported to inhibit choleraic secretion), and furosemide was studied both on basal jejunal absorption and on PGE1-induced secretion of water and electrolytes."	7.65	Further studies on prostaglandin E1-induced jejunal secretion of water and electrolytes in man, with special reference to the influence of ethacrynic acid, furosemide, and aspirin. ( Bernier, JJ; Mary, JY; Matuchansky, C, 1976)
"The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and anti-diuretic hormone (ADH) on the urinary and faecal excretion of water and electrolytes by ponies was studied."	3.66	The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and ADH on electrolyte excretion in ponies. ( Alexander, F, 1982)

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	46 (92.00)	18.7374
1990's	4 (8.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
SCHROEDER, G	1
SANNERSTEDT, R	1
WERKOE, L	1
EARLEY, LE	1
FRIEDLER, RM	1
Singh, BN	1
Richmond, DE	1
Wilson, JD	1
Simmonds, HA	1
North, JD	1
Davidov, M	1
Kakaviatos, N	1
Finnerty, FA	1
Bikhazi, AB	1
Zantut, H	1
Maarawi, N	1
Sayyid, K	1
Karbach, U	1
Wanitschke, R	1
McNabb, WR	1
Noormohamed, FH	1
Brooks, BA	1
Lant, AF	1
Alexander, F	1
Mauro, G	1
Cantino, G	1
Vigiani, L	1
Reisin, IL	1
Rabito, CA	1
Cantiello, HF	1
Beal, AM	1
Kahn, T	1
Bosch, J	1
Levitt, MF	1
Goldstein, MH	1
Veverbrants, E	1
Chazan, JA	1
Garella, S	1
Petersen, KU	1
Heintze, K	1
Busch, LC	1
Heidenreich, O	1
Grajek, S	1
Matuchansky, C	1
Mary, JY	1
Bernier, JJ	1
Johanson, CE	1
Murphy, VA	1
Dyas, M	1
Woods, LL	1
DeYoung, DR	1
Smith, BE	1
Martínez-Maldonado, M	1
Gely, R	1
Tapia, E	1
Benabe, JE	1
Chemtob, S	2
Doray, JL	1
Laudignon, N	2
Papageorgiou, A	1
Varma, DR	1
Aranda, JV	2
Marin, R	1
Ayes, G	1
Proverbio, T	1
Proverbio, F	1
Hartmann, A	2
Langberg, H	1
Holdaas, H	1
Kiil, F	1
Ciampi, A	1
Coupal, L	1
Girchev, RA	1
Natcheff, ND	1
Natochin, IuV	1
Raznik, LV	1
Bakhteeva, VT	1
Ivanov, VB	1
Miazina, EM	1
Meyer zum Gottesberge-Orsulakova, A	1
von Bruchhausen, F	1
Bartelheimer, HK	1
Suzuki, Y	2
Ina, K	2
Yamada, H	1
Yamagami, I	2
Kawaguchi, Y	1
Sakai, S	1
Yamamoto, M	1
Tanaka, S	1
Oda, Y	1
Ross, CP	1
Shumacker, HB	1
Sidorenko, BA	1
Kharchenko, VI	1
Titov, VN	1
Lotova, EV	1
Mel'nichenko, GA	1
Borrello, G	1
Cesari, L	1
Vattimo, A	1
Nardi, P	1
Floyd, WL	1
Irons, GV	1
Orgain, ES	1
Ito, M	1
Barjon, P	1
Fourcade, J	1
Mimran, A	1
Scotti, G	1
Gatti, A	1
Sterz, H	1
Quick, CA	1
Duvall, AJ	1
Powers, SR	1
Batra, SC	1
Daniel, EE	1
Gentili, G	1
Liberti, R	1
Bardi, A	1
Merino, I	1
Generini, G	1
Rendic, Y	1
Plaza de los Reyes, M	1
Porter, GA	1
Bennett, WH	1
Griswold, HE	1
Oelert, H	1
Sebening, F	1
Siegel, W	1
Gifford, RW	1
Koçak, N	1
Ozdoğan, E	1
Cicconetti, C	1
Cantera, N	1
Wayne, HH	1
Kotler, SA	1
McGirr, PS	1
Stoike, RD	1
Nash, HL	1
Fitz, AE	1
Wilson, WR	1
Kirkendall, WM	1
Kioschos, JM	1

Reviews

2 reviews available for ethacrynic acid and Electrolytes

Article	Year
Bicarbonate-dependent solute transport in kidney tubules. Journal of the Oslo city hospitals, 1987, Volume: 37, Issue:6 Topics: Bicarbonates; Biological Transport; Biological Transport, Active; Electrolytes; Ethacrynic Acid; Glo	1987
[Effects of potent diuretics in renal failure]. Nihon rinsho. Japanese journal of clinical medicine, 1974, Volume: 32, Issue:8 Topics: Acute Kidney Injury; Benzoates; Butylamines; Diuresis; Diuretics; Dose-Response Relationship, Drug;	1974

Trials

1 trial available for ethacrynic acid and Electrolytes

Article	Year
Alternating sequential dosing with furosemide and ethacrynic acid in drug tolerance in the newborn. American journal of diseases of children (1960), 1989, Volume: 143, Issue:7 Topics: Creatinine; Diuresis; Drug Administration Schedule; Drug Tolerance; Electrolytes; Ethacrynic Acid; F	1989

Other Studies

47 other studies available for ethacrynic acid and Electrolytes

Article	Year
CLINICAL EXPERIENCES WITH ETHACRYNIC ACID, A NEW NON-THIAZIDE SALURETIC AGENT (MK-595). Acta medica Scandinavica, 1964, Volume: 175 Topics: Aneurysm; Arteriosclerosis; Biomedical Research; Blood; Body Weight; Creatine; Creatinine; Diabetes	1964
RENAL TUBULAR EFFECTS OF ETHACRYNIC ACID. The Journal of clinical investigation, 1964, Volume: 43 Topics: Animals; Body Fluids; Chlorothiazide; Diuretics; Dogs; Electrolytes; Ethacrynic Acid; Kidney Tubules	1964
Evaluation of MK-870: a new potassium-sparing diuretic. British medical journal, 1967, Jan-21, Volume: 1, Issue:5533 Topics: Adult; Aged; Diuresis; Diuretics; Drug Synergism; Edema; Electrolytes; Ethacrynic Acid; Evaluation S	1967
Antihypertensive properties of furosemide. Circulation, 1967, Volume: 36, Issue:1 Topics: Alkaline Phosphatase; Blood Proteins; Blood Urea Nitrogen; Blood Volume; Body Weight; Electrolytes;	1967
Role of ouabain and diuretics on sodium, potassium and chloride retention in perfused rat kidney. Comparative biochemistry and physiology. A, Comparative physiology, 1984, Volume: 77, Issue:3 Topics: Animals; Chlorides; Diuretics; Electrolytes; Ethacrynic Acid; Female; Furosemide; Kidney; Magnesium;	1984
Influence of serosal hydrostatic pressure on net water and electrolyte transport across the isolated rat colonic mucosa exposed to different secretagogues. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:4 Topics: Animals; Anthraquinones; Bisacodyl; Body Water; Cell Membrane Permeability; Cholera Toxin; Colon; De	1984
Renal actions of piretanide and three other "loop" diuretics. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:3 Topics: Absorption; Adult; Body Water; Bumetanide; Diuretics; Electrolytes; Ethacrynic Acid; Furosemide; Hem	1984
The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and ADH on electrolyte excretion in ponies. Journal of veterinary pharmacology and therapeutics, 1982, Volume: 5, Issue:3 Topics: Animals; Body Water; Bumetanide; Chlorides; Diuretics; Electrolytes; Ethacrynic Acid; Furosemide; Ho	1982
[Clinical evaluation of bumetanide in the diuretic treatment of heart failure and liver cirrhosis]. La Clinica terapeutica, 1981, Mar-15, Volume: 96, Issue:5 Topics: Adult; Aged; Bumetanide; Diuresis; Diuretics; Electrolytes; Ethacrynic Acid; Female; Furosemide; Hea	1981
Water and electrolyte balance in protoscoleces of Echinococcus granulosus incubated in vitro: effect of metabolic inhibitors. International journal for parasitology, 1981, Volume: 11, Issue:5 Topics: Animals; Dinitrophenols; Echinococcus; Electrolytes; Energy Metabolism; Ethacrynic Acid; Iodoacetate	1981
Mechanisms of fluid and ion secretion by the parotid gland of the kangaroo, Macropus rufus, assessed by administration of transport-inhibiting drugs. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1995, Volume: 165, Issue:5 Topics: Amiloride; Animals; Bicarbonates; Blood Pressure; Bumetanide; Carotid Arteries; Chlorothiazide; Diur	1995
Effect of sodium nitrate loading on electrolyte transport by the renal tubule. The American journal of physiology, 1975, Volume: 229, Issue:3 Topics: Animals; Bicarbonates; Biological Transport; Chlorides; Chlorothiazide; Diuresis; Dogs; Electrolytes	1975
Ammonium excretion in response to acid loads: effect of metabolic alkalosis and cation depletion. The Journal of laboratory and clinical medicine, 1977, Volume: 89, Issue:6 Topics: Acidosis; Alkalosis; Ammonia; Animals; Bicarbonates; Chlorides; Dogs; Electrolytes; Ethacrynic Acid;	1977
Effects of ethacrynic acid on electrolyte and fluid transport by the guinea pig gallbladder. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 309, Issue:3 Topics: Absorption; Animals; Bicarbonates; Body Fluids; Chlorides; Electrolytes; Ethacrynic Acid; Gallbladde	1979
[Effect of furosemide, ethacrinic acid, acetazolamide and chlorothiazide on renal excretion of sodium, calcium, magnesium, phosphoranes and bicarbonates in persons with normal renal function]. Polskie Archiwum Medycyny Wewnetrznej, 1979, Volume: 62, Issue:5 Topics: Acetazolamide; Adolescent; Adult; Bicarbonates; Calcium; Chlorothiazide; Circadian Rhythm; Diuretics	1979
Further studies on prostaglandin E1-induced jejunal secretion of water and electrolytes in man, with special reference to the influence of ethacrynic acid, furosemide, and aspirin. Gastroenterology, 1976, Volume: 71, Issue:2 Topics: Adult; Albumins; Aspirin; Diuresis; Electrolytes; Ethacrynic Acid; Furosemide; Glucose; Humans; Inte	1976
Ethacrynic acid and furosemide alter Cl, K, and Na distribution between blood, choroid plexus, CSF, and brain. Neurochemical research, 1992, Volume: 17, Issue:11 Topics: Acetazolamide; Amiloride; Animals; Blood Pressure; Brain; Carbon Dioxide; Chlorides; Choroid Plexus;	1992
Regulation of renal hemodynamics after protein feeding: effects of loop diuretics. The American journal of physiology, 1991, Volume: 261, Issue:5 Pt 2 Topics: Animals; Blood Pressure; Dietary Proteins; Dogs; Electrolytes; Ethacrynic Acid; Feedback; Female; Fu	1991
Role of macula densa in diuretics-induced renin release. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 16, Issue:3 Topics: Animals; Blood Pressure; Dinoprostone; Diuretics; Electrolytes; Ethacrynic Acid; Glomerular Filtrati	1990
The effect of cell K+ on the volume regulation in rat kidney cortex cells. Biomedica biochimica acta, 1989, Volume: 48, Issue:4 Topics: Animals; Body Water; Electrolytes; Ethacrynic Acid; Kidney Cortex; Kidney Tubules, Proximal; Kinetic	1989
Glomerulotubular balance during renal sympathetic stimulation. Acta physiologica Scandinavica, 1986, Volume: 127, Issue:2 Topics: Acetazolamide; Adrenergic alpha-Agonists; Animals; Dogs; Electric Stimulation; Electrolytes; Ethacry	1986
Furosemide and ethacrynic acid: risk factors for the occurrence of serum electrolyte abnormalities and metabolic alkalosis in newborns and infants. Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:1 Topics: Acid-Base Equilibrium; Alkalosis; Electrolytes; Ethacrynic Acid; Furosemide; Humans; Infant; Infant,	1989
Excretory function after renal denervation and administration of diuretics to unanesthetized dogs. Biomedica biochimica acta, 1988, Volume: 47, Issue:6 Topics: Acetazolamide; Amiloride; Animals; Denervation; Diuretics; Dogs; Electrolytes; Ethacrynic Acid; Fema	1988
[Pharmacological blockade of the nephrotoxicity of cisplatin in rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 102, Issue:10 Topics: Animals; Cisplatin; Drug Interactions; Electrolytes; Ethacrynic Acid; Female; Furosemide; Kidney; Ma	1986
[Pigment and ion transport in the vestibular organ]. Laryngologie, Rhinologie, Otologie, 1985, Volume: 64, Issue:7 Topics: Animals; Electrolytes; Endolymph; Epithelium; Ethacrynic Acid; Guinea Pigs; Melanins; Melanocytes; O	1985
[Changes in electrolyte movements induced by diuretics in isolated adipose tissue]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2 Topics: Adipose Tissue; Biological Transport; Depression, Chemical; Diuretics; Electrolytes; Ethacrynic Acid	1968
[Pharmacological studies on diuretics. 7. Diuretic activity and mechanism of action of a new thiazide diuretic, penfluzide]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5 Topics: Adenosine Triphosphatases; Alkalosis; Animals; Antihypertensive Agents; Bendroflumethiazide; Blood P	1973
Experimental studies concerning the hemodynamic effects of ethacrynic acid. Annals of surgery, 1972, Volume: 176, Issue:6 Topics: Animals; Bicarbonates; Blood Volume; Carbon Dioxide; Cardiac Output; Diuresis; Dogs; Electrolytes; E	1972
[Comparison of the effectiveness and mechanism of action of the saluretic preparations triamterene and hypothiazide and their combination (triampur) in circulatory insufficiency]. Kardiologiia, 1973, Volume: 13, Issue:4 Topics: Acid-Base Equilibrium; Adult; Aged; Arteriosclerosis; Circadian Rhythm; Coronary Disease; Creatinine	1973
[Effects of hydrochlorothiazide, furosemide and ethacrynic acid on the electrolyte composition of the urine, plasma and edema fluid]. Bollettino della Societa italiana di biologia sperimentale, 1973, Jul-30, Volume: 49, Issue:12 Topics: Adult; Aged; Body Fluids; Edema; Electrolytes; Ethacrynic Acid; Female; Furosemide; Heart Failure; H	1973
Use of ethacrynic acid in refractory edema. The American journal of the medical sciences, 1967, Volume: 254, Issue:2 Topics: Diuresis; Drug Evaluation; Edema; Electrolytes; Ethacrynic Acid; Humans; Male; Middle Aged	1967
[Pharmacological studies of diuretics. 4. Changes of serum uric acid level by the succesive administration of thiazide diuretics and other drugs and effects of uricosuric drugs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1971, Volume: 67, Issue:1 Topics: Administration, Oral; Allopurinol; Ammonium Chloride; Animals; Barbiturates; Blood Glucose; Chloroth	1971
[Transient deafness and ethacrynic acid, possible role of changes in composition of cochlear fluids]. La Presse medicale, 1971, Sep-25, Volume: 79, Issue:40 Topics: Cochlea; Deafness; Electrolytes; Ethacrynic Acid; Female; Humans; Labyrinthine Fluids; Middle Aged	1971
[Ethacrynic acid in the therapy of edematogenic syndromes resistant to other diuretics in senile subjects]. La Clinica terapeutica, 1969, Feb-28, Volume: 48, Issue:4 Topics: Cardiovascular Diseases; Diuresis; Edema; Electrolytes; Ethacrynic Acid; Humans; Hyperthyroidism; Ki	1969
[Clinical studies on the diuretic effect of ethacrynic acid]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1969, Volume: 50, Issue:1 Topics: Diabetes Complications; Diuresis; Edema; Electrolytes; Ethacrynic Acid; Heart Failure; Humans; Hypon	1969
Early changes in the cochlear duct from ethacrynic acid: an electronmicroscopie evaluation. The Laryngoscope, 1970, Volume: 80, Issue:6 Topics: Animals; Atrophy; Cochlea; Edema; Electrolytes; Ethacrynic Acid; Guinea Pigs; Hearing Disorders; Hum	1970
The maintenance of renal function following massive trauma. The Journal of trauma, 1970, Volume: 10, Issue:7 Topics: Animals; Dogs; Electrolytes; Ethacrynic Acid; Hypotension; Kidney; Kidney Function Tests; Mannitol;	1970
Effect of metabolic inhibition on the cation binding and exchange in the rat uterus. Canadian journal of physiology and pharmacology, 1970, Volume: 48, Issue:11 Topics: Animals; Biological Transport, Active; Calcium; Electrolytes; Ethacrynic Acid; Female; In Vitro Tech	1970
[Clinical study of the use of "Spirolang" 50]. Minerva medica, 1971, Feb-28, Volume: 62, Issue:17 Topics: Adult; Aged; Ascites; Chronic Disease; Digitalis Glycosides; Diuresis; Electrolytes; Ethacrynic Acid	1971
[Effect of ethacrynic acid on diuresis, salidiuresis and electrolyte concentration of the plasma in liver cirrhosis patients with ascites]. Revista medica de Chile, 1967, Volume: 95, Issue:6 Topics: Diuresis; Electrolytes; Ethacrynic Acid; Humans; Liver Cirrhosis	1967
Mode of action of ethacrynic acid in congestive heart failure. Archives of internal medicine, 1968, Volume: 121, Issue:3 Topics: Electrolytes; Ethacrynic Acid; Heart Failure; Humans; Injections, Intravenous; Kidney; Kidney Functi	1968
[The diuretic effect of ethacrynic acid in the management of postoperative cardiac insufficiency]. Deutsche medizinische Wochenschrift (1946), 1968, Aug-16, Volume: 93, Issue:33 Topics: Adult; Body Weight; Cardiac Surgical Procedures; Child; Diuresis; Electrolytes; Ethacrynic Acid; Fem	1968
Efficacy of ethacrynic acid in patients with refractory congestive heart failure resistant to meralluride. The American journal of cardiology, 1968, Volume: 22, Issue:2 Topics: Body Weight; Electrolytes; Ethacrynic Acid; Heart Failure; Humans; Hyponatremia; Organomercury Compo	1968
[Effect of ethacrynic acid on diuresis, electrolyte excretion, and renal function in cases of liver cirrhosis]. Turk Tip Cemiyeti mecmuasi, 1968, Volume: 34, Issue:8 Topics: Diuresis; Electrolytes; Ethacrynic Acid; Female; Glomerular Filtration Rate; Humans; Kidney Function	1968
[Clinical experience with the use of a new drug: "ethacrynic acid"]. Il Policlinico. Sezione pratica, 1969, Volume: 76, Issue:3 Topics: Adult; Aged; Ascites; Diuresis; Edema; Electrolytes; Ethacrynic Acid; Female; Heart Failure; Humans;	1969
Ethacrynic acid. Use in ambulatory patients with resistant edema. The American journal of cardiology, 1965, Volume: 16, Issue:5 Topics: Adolescent; Adult; Aged; Blood; Chlorides; Edema; Electrolytes; Ethacrynic Acid; Female; Heart Failu	1965
Cardiorenal hemodynamic effects of ethacrynic acid. American heart journal, 1966, Volume: 71, Issue:2 Topics: Chlorothiazide; Diabetes Insipidus; Edema; Electrolytes; Ethacrynic Acid; Heart; Heart Failure; Hear	1966