ethacrynic acid has been researched along with Disease Models, Animal in 25 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pre- and post-treatment with ethacrynic acid ameliorates ileus and modulates inflammation in the gut wall induced by bowel manipulation." | 7.88 | Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. ( Cruz, RJ; Fink, M; Harada, T, 2018) |
| "To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 7.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
| "Pre- and post-treatment with ethacrynic acid ameliorates ileus and modulates inflammation in the gut wall induced by bowel manipulation." | 3.88 | Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. ( Cruz, RJ; Fink, M; Harada, T, 2018) |
| "To evaluate the long-term effects of ethacrynic acid (ECA) ointment, compared with timolol maleate on intraocular pressure (IOP) in cynomolgus monkey eyes with argon laser-induced glaucoma." | 3.69 | Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes. ( Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF, 1994) |
| "Clofibric acid (CL) is a compound used to control hypertriglyceridemia, and ethacrynic acid (ET) is administered to enhance diuresis." | 1.33 | Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli. ( Balagué, C; De Duffard, AM; De Ruiz, CS; Duffard, R; Nader-Macías, ME; Rey, R; Stürtz, N, 2006) |
| " Dose-response curves (s." | 1.32 | Interaction between metamizol and tramadol in a model of acute visceral pain in rats. ( Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S, 2003) |
| "Gentamicin sulfate was given as a single injection (100 mg/kg of body weight subcutaneously), followed 90 minutes later by varying concentrations of ethacrynic acid intravenously." | 1.29 | A sensitive animal model to assess acute and chronic ototoxic effects. ( Lautermann, J; Schacht, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Harada, T | 1 |
| Fink, M | 1 |
| Cruz, RJ | 1 |
| Jang, JH | 1 |
| Lee, HS | 1 |
| Oh, SH | 1 |
| Park, MH | 1 |
| Yu, DZ | 1 |
| Ding, DL | 1 |
| Yin, SK | 1 |
| Salvi, RJ | 1 |
| Fallon, JB | 1 |
| Shepherd, RK | 2 |
| Brown, M | 1 |
| Irvine, DR | 1 |
| Kim, Y | 1 |
| Gast, SM | 1 |
| Endo, T | 1 |
| Lu, D | 1 |
| Carson, D | 1 |
| Schmidt-Wolf, IG | 1 |
| Warnecke, A | 1 |
| Sasse, S | 1 |
| Wenzel, GI | 1 |
| Hoffmann, A | 1 |
| Gross, G | 1 |
| Paasche, G | 1 |
| Scheper, V | 1 |
| Reich, U | 1 |
| Esser, KH | 1 |
| Lenarz, T | 1 |
| Stöver, T | 1 |
| Wissel, K | 1 |
| Yin, Z | 1 |
| Kng, W | 1 |
| Poveda, R | 1 |
| Planas, E | 1 |
| Pol, O | 1 |
| Romero, A | 1 |
| Sánchez, S | 1 |
| Puig, MM | 1 |
| Suzukawa, J | 1 |
| Omori, K | 1 |
| Yang, L | 1 |
| Inagaki, C | 1 |
| Nourski, KV | 1 |
| Miller, CA | 1 |
| Hu, N | 1 |
| Abbas, PJ | 1 |
| Margineanu, DG | 1 |
| Klitgaard, H | 1 |
| Balagué, C | 1 |
| Stürtz, N | 1 |
| Rey, R | 1 |
| De Ruiz, CS | 1 |
| Nader-Macías, ME | 1 |
| Duffard, R | 1 |
| De Duffard, AM | 1 |
| Rejali, D | 1 |
| Lee, VA | 1 |
| Abrashkin, KA | 1 |
| Humayun, N | 1 |
| Swiderski, DL | 1 |
| Raphael, Y | 1 |
| Hartmann, R | 1 |
| Pfennigdorff, T | 1 |
| Klinke, R | 1 |
| Wang, RF | 1 |
| Podos, SM | 1 |
| Serle, JB | 1 |
| Lee, PY | 1 |
| Neufeld, AH | 1 |
| Deschenes, R | 1 |
| Xu, SA | 1 |
| Chen, Y | 1 |
| Clark, GM | 1 |
| Lautermann, J | 1 |
| Schacht, J | 1 |
| Bosher, SK | 1 |
| Chen, XM | 1 |
| Din, DL | 1 |
| Luo, DF | 1 |
| Huangfu, MS | 1 |
| Jin, XM | 1 |
| Crifò, S | 1 |
| Jacoby, HI | 1 |
| Marshall, CH | 1 |
| Federspil, P | 1 |
| Mausen, H | 1 |
| Witte, MH | 1 |
| Witte, CL | 1 |
| Kintner, K | 1 |
| Thomas, D | 1 |
| Chinitz, JL | 1 |
| Kim, KE | 1 |
| Onesti, G | 1 |
| Swartz, C | 1 |
1 review available for ethacrynic acid and Disease Models, Animal
| Article | Year |
|---|---|
[Research progress of acute kanamycin sulfate-induced deafness in guinea pig].
Topics: Animals; Anti-Bacterial Agents; Cochlea; Deafness; Disease Models, Animal; Ethacrynic Acid; Guinea P | 2012 |
24 other studies available for ethacrynic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus.
Topics: Animals; Disease Models, Animal; Ethacrynic Acid; Gastrointestinal Transit; Ileus; Inflammation Medi | 2018 |
Efficacy of the cat deafening method: Co-administration of ethacrynic acid and kanamycin.
Topics: Animals; Cats; Deafness; Disease Models, Animal; Ethacrynic Acid; Kanamycin; Organ of Corti | 2016 |
[Correlation between reduction of distortion product otoacoustic emission and percentage of outer hair cell missing in chinchillas].
Topics: Animals; Cell Count; Chinchilla; Cisplatin; Disease Models, Animal; Ethacrynic Acid; Hair Cells, Aud | 2009 |
Effects of neonatal partial deafness and chronic intracochlear electrical stimulation on auditory and electrical response characteristics in primary auditory cortex.
Topics: Acoustic Stimulation; Age Factors; Aging; Animals; Animals, Newborn; Auditory Cortex; Auditory Perce | 2009 |
In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma.
Topics: Animals; beta Catenin; Cell Line, Tumor; Disease Models, Animal; Diuretics; Drug Therapy, Combinatio | 2012 |
Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Adhesion; Cell Culture Techniques | 2012 |
Interaction between metamizol and tramadol in a model of acute visceral pain in rats.
Topics: Abdominal Pain; Acute Disease; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2003 |
Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Epilepsy; Ethacryn | 2003 |
Co-administration of kanamycin and ethacrynic acid as a deafening method for acute animal experiments.
Topics: Animals; Deafness; Disease Models, Animal; Drug Synergism; Ethacrynic Acid; Guinea Pigs; Kanamycin | 2004 |
Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.
Topics: Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2006 |
Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Clofibric Acid; Disease Models, Animal; Diuretics; Drug Int | 2006 |
Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cochlear I | 2007 |
Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?
Topics: Acoustic Stimulation; Action Potentials; Animals; Artifacts; Cats; Cochlea; Cochlear Implants; Deafn | 1994 |
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic A | 1994 |
Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Cats; Cochlea; Deafness; Dendrites; Disease Models, Animal; Dose-Response Relationship, Dru | 1993 |
A sensitive animal model to assess acute and chronic ototoxic effects.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Auditory Threshold; Diet, Protein-Restricted; Disease | 1996 |
Ethacrynic acid ototoxicity as a general model in cochlear pathology.
Topics: Action Potentials; Animals; Cell Membrane Permeability; Cochlea; Disease Models, Animal; Endolymph; | 1977 |
[Deafness, induced by sodium ethacrynate in guinea pigs, alleviated by microwave treatment].
Topics: Animals; Cochlea; Disease Models, Animal; Ethacrynic Acid; Guinea Pigs; Hearing Loss, Conductive; Is | 1992 |
Identification of ototoxic drugs by guinea pig shiver audiometry.
Topics: Animals; Audiometry; Auditory Threshold; Avoidance Learning; Deafness; Disease Models, Animal; Drug | 1974 |
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera; | 1972 |
[Experimental studies on ototoxicity of a potent diuretic (ethacrynic acid)].
Topics: Animals; Disease Models, Animal; Ethacrynic Acid; Guinea Pigs; Hearing Disorders; Injections, Intrav | 1973 |
Effect of ethacrynic acid on lymph flow and fluid partition in normal and ascitic dogs.
Topics: Abdomen; Animals; Ascites; Blood Pressure; Blood Proteins; Constriction; Disease Models, Animal; Diu | 1972 |
Pathophysiology and prevention of dextran-40-induced anuria.
Topics: Acute Kidney Injury; Animals; Anuria; Dextrans; Disease Models, Animal; Dogs; Ethacrynic Acid; Hypot | 1971 |