ethacrynic acid has been researched along with Deaf Mutism in 54 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The [14C]-2-deoxyglucose (2-DG) autoradiographic technique was used to study how auditory-related metabolic activity changes with deafness, and how chronic electrical stimulation of the deafened system may modify these changes." | 7.68 | Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus. ( Altschuler, RA; Frey, K; Miller, JM; Schacht, J; Schwartz, DR, 1993) |
| "The [14C]-2-deoxyglucose (2-DG) autoradiographic technique was used to study how auditory-related metabolic activity changes with deafness, and how chronic electrical stimulation of the deafened system may modify these changes." | 3.68 | Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus. ( Altschuler, RA; Frey, K; Miller, JM; Schacht, J; Schwartz, DR, 1993) |
| "Chinchillas deprived of food for 48 h prior to the administration of a combined dose of ethacrynic acid (10 mg/kg) and kanamycin (100 mg/kg) suffered a profound hearing loss." | 3.67 | Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics. ( Hoffman, DW; Jones, KL; Rybak, LP; Whitworth, CA, 1987) |
| "Immediate treatment following deafness was compared with 3-week-delayed NTF treatment." | 1.35 | Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor. ( Altschuler, RA; Bitsche, M; Glueckert, R; Miller, JM; Prieskorn, DM; Schrott-Fischer, A; Zhu, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (72.22) | 18.7374 |
| 1990's | 6 (11.11) | 18.2507 |
| 2000's | 5 (9.26) | 29.6817 |
| 2010's | 4 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jang, JH | 1 |
| Lee, HS | 1 |
| Oh, SH | 1 |
| Park, MH | 1 |
| Liu, H | 1 |
| Ding, DL | 1 |
| Jiang, HY | 1 |
| Wu, XW | 1 |
| Salvi, R | 1 |
| Sun, H | 1 |
| Warnecke, A | 1 |
| Sasse, S | 1 |
| Wenzel, GI | 1 |
| Hoffmann, A | 1 |
| Gross, G | 1 |
| Paasche, G | 1 |
| Scheper, V | 1 |
| Reich, U | 1 |
| Esser, KH | 1 |
| Lenarz, T | 1 |
| Stöver, T | 1 |
| Wissel, K | 1 |
| Yin, Z | 1 |
| Kng, W | 1 |
| Yamasoba, T | 1 |
| Kondo, K | 1 |
| Miyajima, C | 1 |
| Suzuki, M | 1 |
| Nourski, KV | 1 |
| Miller, CA | 1 |
| Hu, N | 1 |
| Abbas, PJ | 1 |
| Rejali, D | 1 |
| Lee, VA | 1 |
| Abrashkin, KA | 1 |
| Humayun, N | 1 |
| Swiderski, DL | 1 |
| Raphael, Y | 2 |
| Kim, YH | 1 |
| Osumi, Y | 1 |
| Izumikawa, M | 1 |
| Glueckert, R | 1 |
| Bitsche, M | 1 |
| Miller, JM | 3 |
| Zhu, Y | 1 |
| Prieskorn, DM | 1 |
| Altschuler, RA | 3 |
| Schrott-Fischer, A | 1 |
| Arnold, W | 1 |
| Nadol, JB | 1 |
| Weidauer, H | 1 |
| Webster, DB | 1 |
| Webster, M | 1 |
| Gomolin, IH | 1 |
| Garschick, E | 1 |
| Hartmann, R | 1 |
| Pfennigdorff, T | 1 |
| Klinke, R | 1 |
| Xu, SA | 1 |
| Shepherd, RK | 2 |
| Chen, Y | 1 |
| Clark, GM | 1 |
| Schwartz, DR | 1 |
| Schacht, J | 1 |
| Frey, K | 1 |
| Martin, RL | 1 |
| Lima da Costa, D | 1 |
| Erre, JP | 1 |
| Charlet de Sauvage, R | 1 |
| Popelar, J | 1 |
| Aran, JM | 1 |
| Guth, PS | 1 |
| Stockwell, M | 1 |
| Gnanapragasam, A | 1 |
| Iaroshevich, VI | 1 |
| Tiedemann, R | 1 |
| Ajodhia, JM | 1 |
| Dix, MR | 1 |
| Matz, GJ | 2 |
| Moran, WB | 1 |
| Beauchamp, GD | 1 |
| Crouch, TC | 1 |
| Hartshorn, DO | 1 |
| Rybak, LP | 2 |
| Hoffman, DW | 1 |
| Whitworth, CA | 1 |
| Jones, KL | 1 |
| Harpur, ES | 1 |
| D'Arcy, PF | 1 |
| Pillay, VK | 2 |
| Schwartz, FD | 2 |
| Aimi, K | 1 |
| Kark, RM | 2 |
| Hanzelik, E | 1 |
| Peppercorn, M | 1 |
| Ng, PS | 1 |
| Conley, CE | 1 |
| Ing, TS | 1 |
| Barjon, P | 2 |
| Fourcade, J | 2 |
| Mimran, A | 2 |
| Crifò, S | 1 |
| Jongkees, LB | 1 |
| Jones, HC | 1 |
| Ernstson, S | 1 |
| Johnsson, LG | 1 |
| Hawkins, JE | 1 |
| Iványi, J | 1 |
| Homer, MJ | 1 |
| Meriwether, WD | 1 |
| Mangi, RJ | 1 |
| Serpick, AA | 1 |
| Johnson, AH | 1 |
| Hamilton, CH | 1 |
| Chaffee, WG | 1 |
| Merrill, JP | 1 |
| Kohonen, A | 1 |
| Jauhiainen, T | 1 |
| Tarkkanen, J | 1 |
| Barillon, A | 1 |
| Felix, J | 1 |
| David, DS | 1 |
| Hitzig, P | 1 |
| Paloheimo, JA | 1 |
| Mathog, RH | 1 |
| Klein, WJ | 1 |
| Beal, DD | 1 |
| Krames, L | 1 |
| Schneider, WJ | 1 |
| Becker, EL | 1 |
4 reviews available for ethacrynic acid and Deaf Mutism
| Article | Year |
|---|---|
[Research progress of acute kanamycin sulfate-induced deafness in guinea pig].
Topics: Animals; Anti-Bacterial Agents; Cochlea; Deafness; Disease Models, Animal; Ethacrynic Acid; Guinea P | 2012 |
Non-sensory cells in the deafened organ of Corti: approaches for repair.
Topics: Animals; Anti-Bacterial Agents; Deafness; Epithelium; Ethacrynic Acid; Genetic Therapy; Hair Cells, | 2007 |
Otorhinolaryngology.
Topics: Animals; Deafness; Ear Diseases; Electrodiagnosis; Ethacrynic Acid; Fibroma; Guinea Pigs; Humans; Ka | 1976 |
Ototoxicity of ethacrynic acid (a persistent clinical problem).
Topics: Deafness; Ethacrynic Acid; Hearing Loss, Conductive; Humans; Male; Middle Aged; Time Factors | 1988 |
50 other studies available for ethacrynic acid and Deaf Mutism
| Article | Year |
|---|---|
Efficacy of the cat deafening method: Co-administration of ethacrynic acid and kanamycin.
Topics: Animals; Cats; Deafness; Disease Models, Animal; Ethacrynic Acid; Kanamycin; Organ of Corti | 2016 |
Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats.
Topics: Animals; Anti-Bacterial Agents; Deafness; Ear, Inner; Ethacrynic Acid; Hearing Loss; Kanamycin; Rats | 2011 |
Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Adhesion; Cell Culture Techniques | 2012 |
Changes in cell proliferation in rat and guinea pig cochlea after aminoglycoside-induced damage.
Topics: Aminoglycosides; Animals; Cell Division; Cochlea; Deafness; Ethacrynic Acid; Guinea Pigs; Hair Cells | 2003 |
Co-administration of kanamycin and ethacrynic acid as a deafening method for acute animal experiments.
Topics: Animals; Deafness; Disease Models, Animal; Drug Synergism; Ethacrynic Acid; Guinea Pigs; Kanamycin | 2004 |
Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cochlear I | 2007 |
Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor.
Topics: Animals; Auditory Pathways; Brain-Derived Neurotrophic Factor; Cochlea; Deafness; Enzyme Inhibitors; | 2008 |
Temporal bone histopathology in human ototoxicity due to loop diuretics.
Topics: Cochlea; Deafness; Diuretics; Ethacrynic Acid; Furosemide; Humans; Male; Middle Aged; Temporal Bone | 1981 |
Multipolar spiral ganglion neurons following organ of Corti loss.
Topics: Animals; Cochlea; Deafness; Denervation; Ethacrynic Acid; Guinea Pigs; Kanamycin; Nerve Regeneration | 1982 |
Ethacrynic acid-induced deafness accompanied by nystagmus.
Topics: Adult; Deafness; Ethacrynic Acid; Humans; Infusions, Parenteral; Male; Nystagmus, Pathologic | 1980 |
Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?
Topics: Acoustic Stimulation; Action Potentials; Animals; Artifacts; Cats; Cochlea; Cochlear Implants; Deafn | 1994 |
Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Cats; Cochlea; Deafness; Dendrites; Disease Models, Animal; Dose-Response Relationship, Dru | 1993 |
Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus.
Topics: Animals; Cochlea; Cochlear Implants; Deafness; Deoxyglucose; Electric Stimulation; Electrodes, Impla | 1993 |
Onset of ototoxicity in the cat is related to onset of auditory function.
Topics: Aging; Animals; Anti-Bacterial Agents; Audiometry; Auditory Cortex; Auditory Threshold; Cats; Cochle | 1995 |
Bioelectrical cochlear noise and its contralateral suppression: relation to background activity of the eighth nerve and effects of sedation and anesthesia.
Topics: Acoustic Stimulation; Aminoglycosides; Anesthesia; Animals; Anti-Bacterial Agents; Body Temperature; | 1997 |
Guanylate cyclase and cyclic guanosine monophosphate in the guinea-pig cochlea.
Topics: Animals; Cochlea; Cochlear Nerve; Cyclic AMP; Cyclic GMP; Deafness; Ethacrynic Acid; Guanylate Cycla | 1977 |
Ototoxic therapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Deafness; Dihydrostreptomycin Sulfate; Ethacrynic A | 1975 |
[Ototoxicity of some drug agents].
Topics: Age Factors; Aminoglycosides; Bleomycin; Cochlea; Deafness; Dimethyl Sulfoxide; Dose-Response Relati | 1975 |
[The conservative treatment of inner ear diseases. A survey of the actual possibilities (author's transl)].
Topics: Anti-Bacterial Agents; Deafness; Diuretics; Edema; Ethacrynic Acid; Hair Cells, Auditory; Hearing Di | 1978 |
Drug-induced deafness and its treatment.
Topics: Aminoglycosides; Anti-Bacterial Agents; Antimalarials; Contraceptives, Oral; Deafness; Ethacrynic Ac | 1976 |
The ototoxic effects of ethacrynic acid in man and animals.
Topics: Animals; Cats; Cochlea; Deafness; Dogs; Dose-Response Relationship, Drug; Ear; Ethacrynic Acid; Fema | 1976 |
Deafness. Review of intravenous ethacrynic acid.
Topics: Acute Kidney Injury; Aminoglycosides; Deafness; Drug Therapy, Combination; Ethacrynic Acid; Humans; | 1975 |
Protective effect of electrical stimulation in the deafened guinea pig cochlea.
Topics: Animals; Auditory Threshold; Cell Nucleus; Cell Survival; Cytoplasm; Deafness; Electric Stimulation; | 1991 |
Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics.
Topics: Animals; Chinchilla; Cochlea; Deafness; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory | 1987 |
Screening drugs for ototoxicity.
Topics: Animals; Deafness; Ethacrynic Acid; Injections, Intraperitoneal; Injections, Intravenous; Kanamycin; | 1972 |
Transient and permanent deafness following treatment with ethacrynic acid in renal failure.
Topics: Adult; Amphetamine; Aortic Valve Insufficiency; Aspartate Aminotransferases; Blood Urea Nitrogen; Ca | 1969 |
Deafness after ethacrynic acid.
Topics: Deafness; Ethacrynic Acid; Humans; Male; Middle Aged; Uremia | 1969 |
Deafness after ethacrynic acid.
Topics: Acute Kidney Injury; Adult; Deafness; Ethacrynic Acid; Female; Humans | 1969 |
[Transient deafness and ethacrynic acid. Possible role of the changes in the composition of cochlear fluids].
Topics: Action Potentials; Ascites; Cochlea; Deafness; Ethacrynic Acid; Female; Humans; Hypokalemia; Labyrin | 1972 |
Identification of ototoxic drugs by guinea pig shiver audiometry.
Topics: Animals; Audiometry; Auditory Threshold; Avoidance Learning; Deafness; Disease Models, Animal; Drug | 1974 |
[Deafness as a result of the use of drugs].
Topics: Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Ethacryni | 1974 |
Intrauterine ototoxicity. A case report and review of literature.
Topics: Abnormalities, Drug-Induced; Adult; Deafness; Ear; Ethacrynic Acid; Female; Fetus; Humans; Kanamycin | 1973 |
Drug-induced deafness.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Et | 1973 |
Ethacrynic acid-induced hearing loss in guinea pigs.
Topics: Animals; Audiometry; Auditory Threshold; Deafness; Ethacrynic Acid; Guinea Pigs; Hearing Tests; Kana | 1972 |
Strial atrophy in clinical and experimental deafness.
Topics: Animals; Atrophy; Basement Membrane; Blood Vessels; Cochlea; Deafness; Dogs; Ethacrynic Acid; Gentam | 1972 |
[Transient deafness during ethacrynic acid therapy].
Topics: Aged; Deafness; Ethacrynic Acid; Humans; Kidney Diseases; Male | 1971 |
Deafness after ethacrynic acid.
Topics: Adult; Deafness; Ethacrynic Acid; Humans; Male | 1971 |
Deafness following standard intravenous dose of ethacrynic acid.
Topics: Anti-Bacterial Agents; Anuria; Deafness; Diuresis; Drug Synergism; Ethacrynic Acid; Female; Humans; | 1971 |
[Transient deafness and ethacrynic acid, possible role of changes in composition of cochlear fluids].
Topics: Cochlea; Deafness; Electrolytes; Ethacrynic Acid; Female; Humans; Labyrinthine Fluids; Middle Aged | 1971 |
Ethacrynic acid: its usefulness and untoward effects.
Topics: Adult; Aged; Cochlea; Deafness; Ear Diseases; Ethacrynic Acid; Female; Hallucinations; Humans; Injec | 1970 |
Kanamycin ototoxicity--possible potentiation by other drugs.
Topics: Adult; Deafness; Drug Synergism; Ethacrynic Acid; Female; Humans; Kanamycin; Male; Mannitol; Middle | 1970 |
Hazards of ethacrynic acid.
Topics: Deafness; Ethacrynic Acid; Humans; Kidney; Kidney Failure, Chronic | 1970 |
Hazards of ethacrynic acid.
Topics: Deafness; Ethacrynic Acid; Humans; Kidney; Kidney Failure, Chronic | 1970 |
Experimental deafness caused by etachrynic acid.
Topics: Animals; Cochlea; Deafness; Ethacrynic Acid; Guinea Pigs | 1970 |
[Ethacrynic acid and hearing disorders].
Topics: Audiometry; Cochlea; Deafness; Ear, Inner; Ethacrynic Acid; Female; Humans; Middle Aged | 1970 |
Diuretics and ototoxicity.
Topics: Adult; Deafness; Diuretics; Ethacrynic Acid; Female; Furosemide; Humans | 1971 |
[Transient deafness-a rare complication of ethacrynic acid therapy].
Topics: Adult; Deafness; Ethacrynic Acid; Humans; Male | 1968 |
Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia.
Topics: Acute Kidney Injury; Adult; Amino Sugars; Anti-Bacterial Agents; Audiometry; Deafness; Ethacrynic Ac | 1969 |
Ototoxicity of ethacrynic acid. Demonstrated in a human temporal bone.
Topics: Acute Kidney Injury; Deafness; Ear, Inner; Ear, Middle; Ethacrynic Acid; Female; Humans; Liver Cirrh | 1969 |
Acute transient hearing loss after ethacrynic acid therapy.
Topics: Adult; Aged; Anuria; Audiometry; Deafness; Ethacrynic Acid; Female; Humans; Male; Middle Aged | 1966 |