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ethacrynic acid and Corneal Diseases

ethacrynic acid has been researched along with Corneal Diseases in 1 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Corneal Diseases: Diseases of the cornea.

Research Excerpts

ExcerptRelevanceReference
" Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0."5.34Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007)
" Three days' daily single 20 microl dosing with 3% SA12590 reduced IOP by 4 mmHg (p<0."1.34Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. ( Epstein, DL; Kirihara, T; Matsugi, T; Rao, PV; Shimazaki, A; Tajima, H, 2007)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shimazaki, A1
Kirihara, T1
Rao, PV1
Tajima, H1
Matsugi, T1
Epstein, DL1

Other Studies

1 other study available for ethacrynic acid and Corneal Diseases

ArticleYear
Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8

    Topics: Administration, Topical; Animals; Cats; Cinnamates; Corneal Diseases; Diuretics; Epithelium, Corneal

2007