ethacrynic acid has been researched along with Conjunctival Diseases in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Conjunctival Diseases: Diseases involving the CONJUNCTIVA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma." | 1.35 | Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. ( Arnold, JJ; Challa, P; Chen, X; Choksi, Y; Epstein, DL; Hatten, J; Shimazaki, A; Toone, EJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnold, JJ | 1 |
| Choksi, Y | 1 |
| Chen, X | 1 |
| Shimazaki, A | 1 |
| Hatten, J | 1 |
| Toone, EJ | 1 |
| Epstein, DL | 1 |
| Challa, P | 1 |
1 other study available for ethacrynic acid and Conjunctival Diseases
| Article | Year |
|---|---|
Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
Topics: Administration, Topical; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cin | 2009 |