ethacrynic acid has been researched along with Condition, Preneoplastic in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (EA) is an inhibitor of rat and human GSTs." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parody, JP | 1 |
| Alvarez, Mde L | 1 |
| Quiroga, A | 1 |
| Ronco, MT | 1 |
| Francés, D | 1 |
| Carnovale, C | 1 |
| Carrillo, MC | 1 |
1 other study available for ethacrynic acid and Condition, Preneoplastic
| Article | Year |
|---|---|
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |