ethacrynic acid has been researched along with Cholangiocellular Carcinoma in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables." | 5.48 | Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells. ( Khunluck, T; Kukongviriyapan, U; Kukongviriyapan, V; Prawan, A; Senggunprai, L; Tusskorn, O, 2018) |
| "Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables." | 1.48 | Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells. ( Khunluck, T; Kukongviriyapan, U; Kukongviriyapan, V; Prawan, A; Senggunprai, L; Tusskorn, O, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, HL | 1 |
| Yeh, CN | 1 |
| Chang, KW | 1 |
| Chen, JT | 1 |
| Lin, KJ | 1 |
| Chiang, LW | 1 |
| Jeng, KC | 1 |
| Wang, WT | 1 |
| Lim, KH | 1 |
| Chen, CG | 1 |
| Lin, KI | 1 |
| Huang, YC | 1 |
| Lin, WJ | 1 |
| Yen, TC | 1 |
| Yu, CS | 1 |
| Tusskorn, O | 1 |
| Khunluck, T | 1 |
| Prawan, A | 1 |
| Senggunprai, L | 1 |
| Kukongviriyapan, U | 1 |
| Kukongviriyapan, V | 1 |
2 other studies available for ethacrynic acid and Cholangiocellular Carcinoma
| Article | Year |
|---|---|
Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: a potential PET tracer for studying glutathione transferase.
Topics: Amides; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Fluorine Radiois | 2012 |
Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells.
Topics: Antineoplastic Agents; Bile Duct Neoplasms; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Dru | 2018 |