ethacrynic acid has been researched along with Carcinoma, Oat Cell in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Addition of ethacrynic acid (3 micrograms ml-1) to treatment of the cell lines with melphalan or with cisplatin did not alter the dose-response curves to these agents." | 1.28 | A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines. ( Rhodes, T; Twentyman, PR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awasthi, S | 1 |
| Singhal, SS | 1 |
| He, N | 1 |
| Chaubey, M | 1 |
| Zimniak, P | 1 |
| Srivastava, SK | 1 |
| Singh, SV | 1 |
| Awasthi, YC | 1 |
| Rhodes, T | 1 |
| Twentyman, PR | 1 |
2 other studies available for ethacrynic acid and Carcinoma, Oat Cell
| Article | Year |
|---|---|
Modulation of doxorubicin cytotoxicity by ethacrynic acid.
Topics: Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Sma | 1996 |
A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Dr | 1992 |