ethacrynic acid has been researched along with Carcinoma, Hepatocellular in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Each compound was evaluated for cytotoxicity to construct dosing regimens in transfection studies." | 1.30 | Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. ( Kroll, DJ; Luckey, SW; Petersen, DR; Tjalkens, RB, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, WY | 1 |
| Cheung, CC | 1 |
| Liu, KW | 1 |
| Fung, KP | 1 |
| Wong, J | 1 |
| Lai, PB | 1 |
| Yeung, JH | 1 |
| Anderson, K | 1 |
| Andrews, R | 1 |
| Yin, L | 1 |
| McLeod, R | 1 |
| MacDonald, C | 1 |
| Hayes, JD | 1 |
| Grant, MH | 1 |
| Tjalkens, RB | 1 |
| Luckey, SW | 1 |
| Kroll, DJ | 1 |
| Petersen, DR | 1 |
| Zhang, K | 1 |
| Chew, M | 1 |
| Yang, EB | 1 |
| Wong, KP | 1 |
| Mack, P | 1 |
4 other studies available for ethacrynic acid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxor | 2010 |
Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Dinitrochlorobenzene; Ethacrynic Acid; | 1998 |
Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element.
Topics: Acrolein; Aldehydes; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carcinoma, Hepato | 1998 |
Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.
Topics: Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Carrier Proteins; Cisplatin | 2001 |