ethacrynic acid has been researched along with Cancer of Liver in 3 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (EA) is an inhibitor of rat and human GSTs." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, D | 1 |
| Cai, H | 1 |
| Jiang, B | 1 |
| Liu, G | 1 |
| Wang, Y | 1 |
| Wang, L | 1 |
| Yao, H | 1 |
| Wu, X | 1 |
| Sun, Y | 1 |
| Xu, J | 1 |
| Parody, JP | 1 |
| Alvarez, Mde L | 1 |
| Quiroga, A | 1 |
| Ronco, MT | 1 |
| Francés, D | 1 |
| Carnovale, C | 1 |
| Carrillo, MC | 1 |
| Yamada, S | 1 |
| Reynolds, TB | 1 |
1 trial available for ethacrynic acid and Cancer of Liver
| Article | Year |
|---|---|
Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites.
Topics: Acid-Base Equilibrium; Amidines; Ascites; Autopsy; Carcinoma; Diuretics; Ethacrynic Acid; Humans; Hy | 1970 |
2 other studies available for ethacrynic acid and Cancer of Liver
| Article | Year |
|---|---|
Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Diterpenes; Diterpenes, Kaurane; Flo | 2013 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |