ethacrynic acid has been researched along with Cancer of Colon in 9 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M)." | 3.70 | Effects of melatonin on proliferation of cancer cell lines. ( Dimitriadis, KA; Geromichalos, GD; Kortsaris, AH; Kouretas, D; Papazisis, KT; Sivridis, E; Tsekreli, OK, 1998) |
| " Since GST inhibitors such as ethacrynic acid are suggested to induce apoptosis in some cell lines, the effect of benastatin A on the survival of mouse colon 26 adenocarcinoma cells was compared with that of ethacrynic acid." | 3.70 | Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A. ( Aoyagi, T; Hayakari, M; Ishikawa, T; Kakizaki, I; Ookawa, K; Tsuchida, S, 2000) |
| "Ethacrynic acid (EA) is a plant phenolic acid that is both an inhibitor and an inducer of glutathione S-transferase (GST) activity." | 1.29 | Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. ( Kuzmich, S; Ranganathan, S; Shen, H; Tew, KD, 1995) |
| "Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans." | 1.29 | Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aizawa, S | 1 |
| Ookawa, K | 2 |
| Kudo, T | 1 |
| Asano, J | 1 |
| Hayakari, M | 2 |
| Tsuchida, S | 2 |
| Shen, H | 1 |
| Ranganathan, S | 1 |
| Kuzmich, S | 2 |
| Tew, KD | 4 |
| Joseph, P | 1 |
| Sharma, MC | 1 |
| Jaiswal, AK | 1 |
| Ciaccio, PJ | 2 |
| Stuart, JE | 1 |
| Khil, MS | 1 |
| Kim, SH | 1 |
| Pinto, JT | 1 |
| Kim, JH | 1 |
| Papazisis, KT | 1 |
| Kouretas, D | 1 |
| Geromichalos, GD | 1 |
| Sivridis, E | 1 |
| Tsekreli, OK | 1 |
| Dimitriadis, KA | 1 |
| Kortsaris, AH | 1 |
| Kakizaki, I | 1 |
| Ishikawa, T | 1 |
| Aoyagi, T | 1 |
| Vanderveer, LA | 1 |
| Walsh, ES | 1 |
| LaCreta, FP | 1 |
9 other studies available for ethacrynic acid and Cancer of Colon
| Article | Year |
|---|---|
Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.
Topics: Acetylcysteine; Antioxidants; Cell Death; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Enzyme | 2003 |
Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells.
Topics: Colonic Neoplasms; Ethacrynic Acid; Glutamate-Cysteine Ligase; Glutathione Transferase; Half-Life; H | 1995 |
Inhibition of NAD(P)H:quinone oxidoreductase1 in ethacrynic acid-resistant human colon carcinoma cells.
Topics: Animals; Colonic Neoplasms; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; E | 1994 |
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Base Sequence; Cattle; Colon; Colonic Neoplas | 1994 |
Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Cell Division; Colonic Neoplasms; Cyclohe | 1993 |
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma | 1996 |
Effects of melatonin on proliferation of cancer cell lines.
Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Cell Survival; Colonic Neoplasms; DNA Repli | 1998 |
Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A.
Topics: Adenocarcinoma; Animals; Apoptosis; Benz(a)Anthracenes; Cell Cycle; Cell Survival; Colonic Neoplasms | 2000 |
Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.
Topics: Cell Division; Cell Line; Colonic Neoplasms; Drug Resistance; Ethacrynic Acid; Glutathione; Glutathi | 1992 |