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ethacrynic acid and Cancer of Colon

ethacrynic acid has been researched along with Cancer of Colon in 9 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Research Excerpts

ExcerptRelevanceReference
"The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M)."3.70Effects of melatonin on proliferation of cancer cell lines. ( Dimitriadis, KA; Geromichalos, GD; Kortsaris, AH; Kouretas, D; Papazisis, KT; Sivridis, E; Tsekreli, OK, 1998)
" Since GST inhibitors such as ethacrynic acid are suggested to induce apoptosis in some cell lines, the effect of benastatin A on the survival of mouse colon 26 adenocarcinoma cells was compared with that of ethacrynic acid."3.70Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A. ( Aoyagi, T; Hayakari, M; Ishikawa, T; Kakizaki, I; Ookawa, K; Tsuchida, S, 2000)
"Ethacrynic acid (EA) is a plant phenolic acid that is both an inhibitor and an inducer of glutathione S-transferase (GST) activity."1.29Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. ( Kuzmich, S; Ranganathan, S; Shen, H; Tew, KD, 1995)
"Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans."1.29Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (77.78)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aizawa, S1
Ookawa, K2
Kudo, T1
Asano, J1
Hayakari, M2
Tsuchida, S2
Shen, H1
Ranganathan, S1
Kuzmich, S2
Tew, KD4
Joseph, P1
Sharma, MC1
Jaiswal, AK1
Ciaccio, PJ2
Stuart, JE1
Khil, MS1
Kim, SH1
Pinto, JT1
Kim, JH1
Papazisis, KT1
Kouretas, D1
Geromichalos, GD1
Sivridis, E1
Tsekreli, OK1
Dimitriadis, KA1
Kortsaris, AH1
Kakizaki, I1
Ishikawa, T1
Aoyagi, T1
Vanderveer, LA1
Walsh, ES1
LaCreta, FP1

Other Studies

9 other studies available for ethacrynic acid and Cancer of Colon

ArticleYear
Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.
    Cancer science, 2003, Volume: 94, Issue:10

    Topics: Acetylcysteine; Antioxidants; Cell Death; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Enzyme

2003
Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Colonic Neoplasms; Ethacrynic Acid; Glutamate-Cysteine Ligase; Glutathione Transferase; Half-Life; H

1995
Inhibition of NAD(P)H:quinone oxidoreductase1 in ethacrynic acid-resistant human colon carcinoma cells.
    Biochemical pharmacology, 1994, Jun-01, Volume: 47, Issue:11

    Topics: Animals; Colonic Neoplasms; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; E

1994
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
    Biochimica et biophysica acta, 1994, Jun-28, Volume: 1186, Issue:1-2

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Base Sequence; Cattle; Colon; Colonic Neoplas

1994
Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
    Molecular pharmacology, 1993, Volume: 43, Issue:6

    Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Cell Division; Colonic Neoplasms; Cyclohe

1993
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
    International journal of radiation oncology, biology, physics, 1996, Jan-15, Volume: 34, Issue:2

    Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma

1996
Effects of melatonin on proliferation of cancer cell lines.
    Journal of pineal research, 1998, Volume: 25, Issue:4

    Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Cell Survival; Colonic Neoplasms; DNA Repli

1998
Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:11

    Topics: Adenocarcinoma; Animals; Apoptosis; Benz(a)Anthracenes; Cell Cycle; Cell Survival; Colonic Neoplasms

2000
Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.
    The Biochemical journal, 1992, Jan-01, Volume: 281 ( Pt 1)

    Topics: Cell Division; Cell Line; Colonic Neoplasms; Drug Resistance; Ethacrynic Acid; Glutathione; Glutathi

1992