ethacrynic acid has been researched along with Bright Disease in 14 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Bright Disease: A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (10 mg/kg subcutaneously 15 days) significantly facilitated the experimental glomerulonephritis in rats." | 7.68 | [Effect of ethacrynic acid on the course of cytotoxic glomerulonephritis]. ( Averev, IaF; Oberemok, AV; Talalaev, SV, 1991) |
| "Ethacrynic acid (10 mg/kg subcutaneously 15 days) significantly facilitated the experimental glomerulonephritis in rats." | 3.68 | [Effect of ethacrynic acid on the course of cytotoxic glomerulonephritis]. ( Averev, IaF; Oberemok, AV; Talalaev, SV, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAGEDORN, CW | 1 |
| KAPLAN, AA | 1 |
| HULET, WH | 1 |
| James, JA | 1 |
| Lewy, JE | 1 |
| Werning, C | 1 |
| Loggie, JM | 1 |
| Kleinman, LI | 1 |
| Van Maanen, EF | 1 |
| Averev, IaF | 1 |
| Talalaev, SV | 1 |
| Oberemok, AV | 1 |
| Witte, MK | 1 |
| Stork, JE | 1 |
| Blumer, JL | 1 |
| Pohl, JE | 1 |
| Swales, JD | 1 |
| Thurston, H | 1 |
| Holzgreve, H | 1 |
| Coodley, EL | 1 |
| Garfield, A | 1 |
| Guiterrez, J | 1 |
| Platt, B | 1 |
| Ratner, NA | 1 |
| Glezer, GA | 1 |
| Groznovich, NA | 1 |
| Moskalenko, NP | 1 |
| Quellhorst, E | 1 |
| Scheler, F | 1 |
| Gentili, G | 1 |
| Liberti, R | 1 |
| Brass, H | 1 |
2 reviews available for ethacrynic acid and Bright Disease
| Article | Year |
|---|---|
Diuretics in infancy.
Topics: Acute Disease; Benzothiadiazines; Diet, Sodium-Restricted; Diuretics; Diuretics, Osmotic; Edema; Eth | 1981 |
Diuretic therapeutics in the pediatric patient.
Topics: Acid-Base Equilibrium; Bumetanide; Calcium; Child; Child, Preschool; Chlorides; Diuretics; Ethacryni | 1986 |
12 other studies available for ethacrynic acid and Bright Disease
| Article | Year |
|---|---|
PROLONGED ADMINISTRATION OF ETHACRYNIC ACID IN PATIENTS WITH CHRONIC RENAL DISEASE.
Topics: Acid-Base Equilibrium; Diabetic Nephropathies; Diarrhea; Diuretics; Drug Therapy; Edema; Ethacrynic | 1965 |
Ethacrynic acid in edematous states in children.
Topics: Alkalosis; Bicarbonates; Body Weight; Child; Child, Preschool; Chlorides; Ethacrynic Acid; Glomerulo | 1967 |
[The therapy of edematous diseases].
Topics: Antihypertensive Agents; Bed Rest; Diabetes Insipidus; Diuretics; Diuretics, Osmotic; Edema; Ethacry | 1977 |
Renal function and diuretic therapy in infants and children. Part III.
Topics: Adolescent; Calcium; Child; Child, Preschool; Diuresis; Diuretics; Edema; Ethacrynic Acid; Female; F | 1975 |
[Effect of ethacrynic acid on the course of cytotoxic glomerulonephritis].
Topics: Animals; Creatinine; Diuresis; Ethacrynic Acid; Glomerulonephritis; Kidney; Male; Potassium; Rats; S | 1991 |
Renal effects of diazoxide and frusemide and interrelationships.
Topics: Creatinine; Diazoxide; Diuretics; Ethacrynic Acid; Female; Follow-Up Studies; Furans; Furosemide; Gl | 1974 |
[Diuretics in acute glomerulonephritis?].
Topics: Acute Disease; Diuretics; Ethacrynic Acid; Furosemide; Glomerulonephritis; Humans; Kidney Diseases; | 1973 |
Nondialytic management of chronic uremia.
Topics: Administration, Oral; Adult; Blood Urea Nitrogen; Chronic Disease; Creatinine; Diuresis; Diuretics; | 1973 |
[Diuretic and hypotensive action of uregite (ethacrynic acid)].
Topics: Amyloidosis; Arteries; Blood Pressure; Diuresis; Ethacrynic Acid; Familial Mediterranean Fever; Glom | 1971 |
[The effectivness of ethacrynic acid, amiloride HCl and aldadiene K in kidney insufficiency].
Topics: Administration, Oral; Adult; Body Weight; Calcium; Creatinine; Diuretics; Drug Synergism; Ethacrynic | 1970 |
[Clinical study of the use of "Spirolang" 50].
Topics: Adult; Aged; Ascites; Chronic Disease; Digitalis Glycosides; Diuresis; Electrolytes; Ethacrynic Acid | 1971 |
[The long-term therapy of glomerulonephritis without renal insufficiency].
Topics: Azathioprine; Chronic Disease; Cortisone; Diet Therapy; Ethacrynic Acid; Furosemide; Glomerulonephri | 1968 |