ethacrynic acid has been researched along with Breast Cancer in 10 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin, the chief hormone secreted by the pineal gland, has been previously shown to inhibit human breast cancer cell growth at the physiological concentration of 1 nM in vitro." | 7.69 | Physiological melatonin inhibition of human breast cancer cell growth in vitro: evidence for a glutathione-mediated pathway. ( Blask, DE; Wilson, ST; Zalatan, F, 1997) |
| "Ethacrynic acid (EA) is an FDA approved drug that may have antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling." | 5.43 | Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. ( Chen, T; Gao, N; Hu, Y; Huang, X; Jia, T; Jin, G; Jin, Z; Liu, B; Peng, B; Wang, Z; Zhang, N, 2016) |
| "The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M)." | 3.70 | Effects of melatonin on proliferation of cancer cell lines. ( Dimitriadis, KA; Geromichalos, GD; Kortsaris, AH; Kouretas, D; Papazisis, KT; Sivridis, E; Tsekreli, OK, 1998) |
| "Melatonin, the chief hormone secreted by the pineal gland, has been previously shown to inhibit human breast cancer cell growth at the physiological concentration of 1 nM in vitro." | 3.69 | Physiological melatonin inhibition of human breast cancer cell growth in vitro: evidence for a glutathione-mediated pathway. ( Blask, DE; Wilson, ST; Zalatan, F, 1997) |
| "Ethacrynic acid (EA) is an FDA approved drug that may have antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling." | 1.43 | Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. ( Chen, T; Gao, N; Hu, Y; Huang, X; Jia, T; Jin, G; Jin, Z; Liu, B; Peng, B; Wang, Z; Zhang, N, 2016) |
| "In the present study of a human breast cancer cell line (MCF-7) exhibiting about 6-fold resistance to 4HC (MCF/HC), cellular levels of glutathione (GSH) were increased 1." | 1.29 | Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. ( Chen, G; Waxman, DJ, 1995) |
| "Glutathione (GSH) and glutathione S-transferases (GSTs) play an important role in the protection of cells against toxic effects of many electrophilic drugs and chemicals." | 1.29 | Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. ( Chen, G; Waxman, DJ, 1994) |
| "Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans." | 1.29 | Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, B | 1 |
| Huang, X | 1 |
| Hu, Y | 1 |
| Chen, T | 1 |
| Peng, B | 1 |
| Gao, N | 1 |
| Jin, Z | 1 |
| Jia, T | 1 |
| Zhang, N | 1 |
| Wang, Z | 1 |
| Jin, G | 1 |
| Johansson, K | 1 |
| Ito, M | 1 |
| Schophuizen, CM | 1 |
| Mathew Thengumtharayil, S | 1 |
| Heuser, VD | 1 |
| Zhang, J | 1 |
| Shimoji, M | 1 |
| Vahter, M | 1 |
| Ang, WH | 1 |
| Dyson, PJ | 1 |
| Shibata, A | 1 |
| Shuto, S | 1 |
| Ito, Y | 1 |
| Abe, H | 1 |
| Morgenstern, R | 1 |
| Chen, G | 2 |
| Waxman, DJ | 2 |
| Khil, MS | 1 |
| Kim, SH | 1 |
| Pinto, JT | 1 |
| Kim, JH | 1 |
| Blask, DE | 1 |
| Wilson, ST | 1 |
| Zalatan, F | 1 |
| Papazisis, KT | 1 |
| Kouretas, D | 1 |
| Geromichalos, GD | 1 |
| Sivridis, E | 1 |
| Tsekreli, OK | 1 |
| Dimitriadis, KA | 1 |
| Kortsaris, AH | 1 |
| Townsend, AJ | 2 |
| Tu, CP | 1 |
| Cowan, KH | 2 |
| Moscow, JA | 1 |
| Lenhard, RE | 1 |
1 trial available for ethacrynic acid and Breast Cancer
| Article | Year |
|---|---|
Clinical case records in chemotherapy: the management of hypercalcemia complicating cancer.
Topics: Adult; Aged; Breast Neoplasms; Calcium; Citrates; Clinical Trials as Topic; Cyclophosphamide; Edetic | 1971 |
9 other studies available for ethacrynic acid and Breast Cancer
| Article | Year |
|---|---|
Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer.
Topics: Afatinib; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2016 |
Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cisplatin; Cricetinae | 2011 |
Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells.
Topics: Aldehyde Dehydrogenase; Aldehydes; Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cyclophospha | 1995 |
Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells.
Topics: Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; E | 1994 |
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma | 1996 |
Physiological melatonin inhibition of human breast cancer cell growth in vitro: evidence for a glutathione-mediated pathway.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Breast Neoplasms; Buthionine Sulfo | 1997 |
Effects of melatonin on proliferation of cancer cell lines.
Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Cell Survival; Colonic Neoplasms; DNA Repli | 1998 |
Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents.
Topics: Antineoplastic Agents; Breast Neoplasms; DNA; Drug Resistance; Ethacrynic Acid; Gene Expression; Glu | 1992 |
Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.
Topics: Breast Neoplasms; Doxorubicin; Drug Resistance; Ethacrynic Acid; Female; Glutathione Transferase; Hu | 1989 |