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ethacrynic acid and Body Weight

ethacrynic acid has been researched along with Body Weight in 34 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
" Gentamicin in combination with 20 mg ethacrynic acid/kg body weight produced a hearing loss of 95 dB in animals on a low protein diet and 12 dB in animals on a full protein diet."	3.69	[Reduced nutritional status enhances ototoxicity]. ( Lautermann, J; Schacht, J, 1995)
"Although it is well known that ethacrynic acid (EA) can enhance gentamicin (GM) ototoxicity, there has been no systematic study of the relationship between dosing parameters and inner ear pathology."	1.31	Chinchilla models of selective cochlear hair cell loss. ( Ding, D; Jiang, H; McFadden, SL; Salvi, RJ; Woo, JM, 2002)

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (94.12)	18.7374
1990's	1 (2.94)	18.2507
2000's	1 (2.94)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
McFadden, SL	1
Ding, D	1
Jiang, H	1
Woo, JM	1
Salvi, RJ	1
SCHROEDER, G	1
SANNERSTEDT, R	1
WERKOE, L	1
BERNSTEIN, A	1
ODZE, M	1
CREWS, A	1
SIMON, F	1
CANNON, PJ	1
HEINEMANN, HO	1
ALBERT, MS	1
LARAGH, JH	1
WINTERS, RW	1
Vorburger, C	1
Cottier, P	1
Edwards, KD	1
Sinnett, PF	1
Stewart, JH	1
Davidov, M	1
Kakaviatos, N	1
Finnerty, FA	1
de Sousa, RC	1
Jenny, M	1
James, JA	1
Brooks, BA	1
Lant, AF	1
McNabb, WR	1
Noormohamed, FH	1
Lautermann, J	1
Schacht, J	1
Levin, DL	1
Chou, SY	1
Ferder, LF	1
Liebman, PH	1
Porush, JG	1
Arruda, JA	1
Gutierrez, LF	1
Kurtzman, NA	1
Montgomery, RG	2
Patel, NC	2
Lee, JG	2
Kohner, EM	1
Dollery, CT	1
Lowy, C	1
Schumer, B	1
Garnett, ES	1
Webber, CE	1
Glassman, VP	1
Safirstein, R	1
DiScala, VA	1
Oelert, H	2
Demberg, K	1
Sebening, F	2
Jacoby, HI	1
Marshall, CH	1
Espiner, EA	2
Tucci, JR	2
Jagger, PI	2
Pauk, GL	1
Lauler, DP	2
Radó, JP	1
Marosi, J	1
Takó, J	1
Perez-Stable, EC	1
Materson, BJ	1
Wombolt, DG	1
Michie, DD	1
Cohen, JJ	1
Chazan, JA	1
Garella, S	1
Quellhorst, E	2
Scheler, F	2
Steele, TH	1
Felman, D	1
Theoleyre, J	1
Dupoizat, H	1
Siegel, W	1
Gifford, RW	1
Russell, RP	1
Lindeman, RD	1
Prescott, LF	1
Steigmann, F	1
Oz, R	1
Dubin, A	1

Reviews

1 review available for ethacrynic acid and Body Weight

Article	Year
Diuretic drug therapy of edema. The Medical clinics of North America, 1971, Volume: 55, Issue:2 Topics: Ambulatory Care; Ascites; Body Weight; Chlorides; Diuresis; Diuretics; Edema; Ethacrynic Acid; Furos	1971

Trials

6 trials available for ethacrynic acid and Body Weight

Article	Year
A comparison of the diuretic effects of prostaglandin A1, sodium ethacrynate, and placebo. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2 Topics: Adult; Blood Pressure; Body Weight; Chlorides; Diuresis; Ethacrynic Acid; Humans; Infusions, Parente	1975
Effect of diuretic therapy on glucose tolerance in hypertensive patients. Lancet (London, England), 1971, May-15, Volume: 1, Issue:7707 Topics: Age Factors; Blood Glucose; Body Weight; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Fasting; Fat	1971
A comparison of the diuretic effects of prostaglandin A1, sodium ethacrynate, and placebo. Prostaglandins, 1973, Volume: 4, Issue:3 Topics: Adult; Blood Pressure; Body Weight; Chlorides; Diuresis; Ethacrynic Acid; Humans; Injections, Intrav	1973
The effect of acute diuretic-induced extracellular volume depletion on aldosterone secretion in normal man. Clinical science, 1967, Volume: 33, Issue:1 Topics: Adult; Aldosterone; Body Weight; Chlorides; Clinical Trials as Topic; Diet; Diuresis; Ethacrynic Aci	1967
High doses of spironolactone (Aldactone, SC-14266, Verospirone) alone and in combination with triamterene and-or diuretics in the treatment of refractory edema associated with secondary hyperaldosteronism. Endokrinologie, 1970, Volume: 57, Issue:1 Topics: Adult; Aged; Body Weight; Chlorides; Clinical Trials as Topic; Clopamide; Creatinine; Diet, Sodium-R	1970
Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide. JAMA, 1968, Jul-01, Volume: 205, Issue:1 Topics: Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Blood Urea Nitroge	1968

Other Studies

27 other studies available for ethacrynic acid and Body Weight

Article	Year
Chinchilla models of selective cochlear hair cell loss. Hearing research, 2002, Volume: 174, Issue:1-2 Topics: Animals; Anti-Bacterial Agents; Body Weight; Cell Death; Chinchilla; Cochlea; Diuretics; Dose-Respon	2002
CLINICAL EXPERIENCES WITH ETHACRYNIC ACID, A NEW NON-THIAZIDE SALURETIC AGENT (MK-595). Acta medica Scandinavica, 1964, Volume: 175 Topics: Aneurysm; Arteriosclerosis; Biomedical Research; Blood; Body Weight; Creatine; Creatinine; Diabetes	1964
ETHACRYNIC ACID: A NEW POTENT DIURETIC. The American journal of the medical sciences, 1965, Volume: 249 Topics: Alkalosis; Blood Chemical Analysis; Blood Urea Nitrogen; Body Weight; Digitalis Glycosides; Diuresis	1965
"CONTRACTION" ALKALOSIS AFTER DIURESIS OF EDEMATOUS PATIENTS WITH ETHACRYNIC ACID. Annals of internal medicine, 1965, Volume: 62 Topics: Acid-Base Equilibrium; Alkalosis; Bicarbonates; Blood; Body Fluids; Body Weight; Chlorides; Diuresis	1965
[Saluretics in the treatment of cardiac and renal edema]. Munchener medizinische Wochenschrift (1950), 1966, Dec-23, Volume: 108, Issue:51 Topics: Blood Circulation; Body Weight; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart	1966
Ethacrynic acid: assessment of saluretic and diuretic potency in patients with severe chronic renal failure. The Medical journal of Australia, 1967, Feb-25, Volume: 1, Issue:8 Topics: Adult; Aged; Bendroflumethiazide; Blood Urea Nitrogen; Body Weight; Chlorides; Creatine; Diuretics;	1967
Antihypertensive properties of furosemide. Circulation, 1967, Volume: 36, Issue:1 Topics: Alkaline Phosphatase; Blood Proteins; Blood Urea Nitrogen; Blood Volume; Body Weight; Electrolytes;	1967
Clinical study of a new diuretic--ethacrynic acid. Helvetica medica acta, 1967, Volume: 33, Issue:5 Topics: Alkalosis; Ascites; Blood; Body Weight; Chlorides; Edema; Ethacrynic Acid; Heart Failure; Humans; Li	1967
Ethacrynic acid in edematous states in children. The Journal of pediatrics, 1967, Volume: 71, Issue:6 Topics: Alkalosis; Bicarbonates; Body Weight; Child; Child, Preschool; Chlorides; Ethacrynic Acid; Glomerulo	1967
Renal actions of a uricosuric diuretic, racemic indacrinone, in man: comparison with ethacrynic acid and hydrochlorothiazide. British journal of clinical pharmacology, 1984, Volume: 17, Issue:5 Topics: Body Weight; Diuretics; Ethacrynic Acid; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hy	1984
[Reduced nutritional status enhances ototoxicity]. Laryngo- rhino- otologie, 1995, Volume: 74, Issue:12 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Auditory Pathways; Auditory Threshold; Body W	1995
The effect of the plasma bicarbonate level on proximal tubule sodium reabsorption in NH4Cl-loaded dogs. The Journal of laboratory and clinical medicine, 1976, Volume: 87, Issue:5 Topics: Acidosis; Ammonium Chloride; Animals; Bicarbonates; Body Weight; Chlorides; Diuresis; Dogs; Ethacryn	1976
Diuretic agents and glucose reabsorption. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 149, Issue:1 Topics: Absorption; Acetazolamide; Animals; Body Weight; Chlorothiazide; Diuretics; Dogs; Ethacrynic Acid; F	1975
Changes in blood-volume produced by treatment in the nephrotic syndrome. Lancet (London, England), 1967, Oct-14, Volume: 2, Issue:7520 Topics: Adolescent; Adult; Aged; Blood Volume; Blood Volume Determination; Body Weight; Child; Chlorothiazid	1967
Effects of metabolic acidosis on proximal tubule ion reabsorption in dog kidney. The American journal of physiology, 1974, Volume: 227, Issue:4 Topics: Acid-Base Equilibrium; Acidosis; Ammonium Chloride; Animals; Body Weight; Calcium; Chlorothiazide; D	1974
[Diuretic treatment with ethacrynic acid after open heart surgery]. Thoraxchirurgie, vaskulare Chirurgie, 1972, Volume: 20, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Anuria; Body Weight; Cardiac Surgical Procedures; Child; Child	1972
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat. Nature, 1972, Jan-21, Volume: 235, Issue:5334 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera;	1972
Ethacrynic acid in the out-patient management of cardiac edema. Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:7 Topics: Adult; Aged; Blood Pressure; Body Weight; Ethacrynic Acid; Female; Heart Failure; Humans; Male; Midd	1970
The interrelationship between ECF volume and ECF anion composition in the regulation of sodium excretion. Clinical science, 1970, Volume: 39, Issue:4 Topics: Animals; Bicarbonates; Body Weight; Chlorides; Dogs; Ethacrynic Acid; Extracellular Space; Feces; Fe	1970
[The effectivness of ethacrynic acid, amiloride HCl and aldadiene K in kidney insufficiency]. Klinische Wochenschrift, 1970, Apr-15, Volume: 48, Issue:8 Topics: Administration, Oral; Adult; Body Weight; Calcium; Creatinine; Diuretics; Drug Synergism; Ethacrynic	1970
Dual effect of potent diuretics on renal handling of phosphate in man. Metabolism: clinical and experimental, 1971, Volume: 20, Issue:8 Topics: Adult; Body Weight; Calcium; Ethacrynic Acid; Extracellular Space; Furosemide; Glomerular Filtration	1971
[Trial of ethacrynic acid in treatment of excessive weight gain and arterial hypertension in pregnancy]. Lyon medical, 1967, May-07, Volume: 217, Issue:19 Topics: Adult; Arteries; Body Weight; Diabetes Mellitus; Ethacrynic Acid; Female; Humans; Hypertension; Infa	1967
[The diuretic effect of ethacrynic acid in the management of postoperative cardiac insufficiency]. Deutsche medizinische Wochenschrift (1946), 1968, Aug-16, Volume: 93, Issue:33 Topics: Adult; Body Weight; Cardiac Surgical Procedures; Child; Diuresis; Electrolytes; Ethacrynic Acid; Fem	1968
Efficacy of ethacrynic acid in patients with refractory congestive heart failure resistant to meralluride. The American journal of cardiology, 1968, Volume: 22, Issue:2 Topics: Body Weight; Electrolytes; Ethacrynic Acid; Heart Failure; Humans; Hyponatremia; Organomercury Compo	1968
Effect of acute diuresis on aldosterone secretion in edematous patients. The New England journal of medicine, 1969, May-22, Volume: 280, Issue:21 Topics: Adult; Aldosterone; Body Weight; Chlorides; Diet Therapy; Diet, Sodium-Restricted; Diuresis; Diureti	1969
[On the management of renal acidosis using sodium bicarbonate and ethacrynic acid]. Deutsche medizinische Wochenschrift (1946), 1969, Jul-04, Volume: 94, Issue:27 Topics: Acidosis, Renal Tubular; Acute Kidney Injury; Adult; Bicarbonates; Blood Pressure; Body Weight; Etha	1969
Newer diuretics in the treatment of cardiac or hepatic disease in elderly patients. Journal of the American Geriatrics Society, 1966, Volume: 14, Issue:12 Topics: Ascites; Benzothiadiazines; Blood Glucose; Blood Urea Nitrogen; Body Weight; Cardiovascular Diseases	1966