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ethacrynic acid and Benign Neoplasms, Brain

ethacrynic acid has been researched along with Benign Neoplasms, Brain in 6 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Research Excerpts

ExcerptRelevanceReference
"The DNA repair and detoxifying enzymes, O(6)-methylguanine-DNA-methyltransferase (MGMT) and glutathione-S-transferase (GST), may be responsible fpr poor response to alkylating agents in glioblastoma treatment."7.74Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. ( Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S, 2008)
"The DNA repair and detoxifying enzymes, O(6)-methylguanine-DNA-methyltransferase (MGMT) and glutathione-S-transferase (GST), may be responsible fpr poor response to alkylating agents in glioblastoma treatment."3.74Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. ( Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S, 2008)
"Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans."1.29Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Juillerat-Jeanneret, L1
Bernasconi, CC1
Bricod, C1
Gros, S1
Trepey, S1
Benhattar, J1
Janzer, RC1
Valdes, RM1
Huff, MO1
El-Masri, MA1
El-Mallakh, RS1
Khil, MS1
Kim, SH1
Pinto, JT1
Kim, JH1
Reulen, HJ1
Murphy, GP1
Mirand, EA1
Johnston, GS1
Gibbons, RP1
Schirmer, HK1
Scott, WW1
Miyazaki, Y1
Suematsu, K1
Nakamura, J1

Reviews

1 review available for ethacrynic acid and Benign Neoplasms, Brain

ArticleYear
Vasogenic brain oedema. New aspects in its formation, resolution and therapy.
    British journal of anaesthesia, 1976, Volume: 48, Issue:8

    Topics: Brain Abscess; Brain Edema; Brain Neoplasms; Capillary Permeability; Cerebrovascular Circulation; Ce

1976

Other Studies

5 other studies available for ethacrynic acid and Benign Neoplasms, Brain

ArticleYear
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
    Cancer investigation, 2008, Volume: 26, Issue:6

    Topics: Alkylating Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; DNA Methylatio

2008
Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cells.
    Bipolar disorders, 2003, Volume: 5, Issue:2

    Topics: Bipolar Disorder; Blotting, Western; Brain Neoplasms; Diuretics; Ethacrynic Acid; Humans; Immunoblot

2003
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
    International journal of radiation oncology, biology, physics, 1996, Jan-15, Volume: 34, Issue:2

    Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma

1996
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
    The Journal of urology, 1968, Volume: 99, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El

1968
Effect of ethacrynic acid on lowering of intracranial pressure.
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:12

    Topics: Adolescent; Adult; Brain Edema; Brain Neoplasms; Child; Chlorides; Craniocerebral Trauma; Depression

1969