ethacrynic acid has been researched along with Benign Neoplasms, Brain in 6 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The DNA repair and detoxifying enzymes, O(6)-methylguanine-DNA-methyltransferase (MGMT) and glutathione-S-transferase (GST), may be responsible fpr poor response to alkylating agents in glioblastoma treatment." | 7.74 | Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. ( Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S, 2008) |
| "The DNA repair and detoxifying enzymes, O(6)-methylguanine-DNA-methyltransferase (MGMT) and glutathione-S-transferase (GST), may be responsible fpr poor response to alkylating agents in glioblastoma treatment." | 3.74 | Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. ( Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S, 2008) |
| "Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans." | 1.29 | Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. ( Khil, MS; Kim, JH; Kim, SH; Pinto, JT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Juillerat-Jeanneret, L | 1 |
| Bernasconi, CC | 1 |
| Bricod, C | 1 |
| Gros, S | 1 |
| Trepey, S | 1 |
| Benhattar, J | 1 |
| Janzer, RC | 1 |
| Valdes, RM | 1 |
| Huff, MO | 1 |
| El-Masri, MA | 1 |
| El-Mallakh, RS | 1 |
| Khil, MS | 1 |
| Kim, SH | 1 |
| Pinto, JT | 1 |
| Kim, JH | 1 |
| Reulen, HJ | 1 |
| Murphy, GP | 1 |
| Mirand, EA | 1 |
| Johnston, GS | 1 |
| Gibbons, RP | 1 |
| Schirmer, HK | 1 |
| Scott, WW | 1 |
| Miyazaki, Y | 1 |
| Suematsu, K | 1 |
| Nakamura, J | 1 |
1 review available for ethacrynic acid and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Vasogenic brain oedema. New aspects in its formation, resolution and therapy.
Topics: Brain Abscess; Brain Edema; Brain Neoplasms; Capillary Permeability; Cerebrovascular Circulation; Ce | 1976 |
5 other studies available for ethacrynic acid and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
Topics: Alkylating Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; DNA Methylatio | 2008 |
Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cells.
Topics: Bipolar Disorder; Blotting, Western; Brain Neoplasms; Diuretics; Ethacrynic Acid; Humans; Immunoblot | 2003 |
Ethacrynic acid: a novel radiation enhancer in human carcinoma cells.
Topics: Brain Neoplasms; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Ethacrynic Acid; Female; Glioma | 1996 |
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El | 1968 |
Effect of ethacrynic acid on lowering of intracranial pressure.
Topics: Adolescent; Adult; Brain Edema; Brain Neoplasms; Child; Chlorides; Craniocerebral Trauma; Depression | 1969 |