ethacrynic acid has been researched along with B-Cell Chronic Lymphocytic Leukemia in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, W | 1 |
| Zhu, H | 1 |
| Fu, Y | 1 |
| Shen, W | 1 |
| Miao, K | 1 |
| Hong, M | 1 |
| Xu, W | 1 |
| Fan, L | 1 |
| Young, KH | 1 |
| Liu, P | 1 |
| Li, J | 1 |
| Lu, D | 1 |
| Liu, JX | 1 |
| Endo, T | 1 |
| Zhou, H | 1 |
| Yao, S | 1 |
| Willert, K | 1 |
| Schmidt-Wolf, IG | 1 |
| Kipps, TJ | 1 |
| Carson, DA | 1 |
| Petrini, M | 1 |
| Conte, A | 1 |
| Caracciolo, F | 1 |
| Sabbatini, A | 1 |
| Grassi, B | 1 |
| Ronca, G | 1 |
| Twentyman, PR | 1 |
| Lambert, E | 1 |
| Müller, M | 1 |
| Rees, JK | 1 |
4 other studies available for ethacrynic acid and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Deubiquitinating Enzyme CYLD; Ethacrynic Acid; Female; Ge | 2016 |
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.
Topics: Acetylcysteine; beta Catenin; Cell Line, Tumor; Cell Survival; Cyclin D1; Drug Screening Assays, Ant | 2009 |
Reversing of chlorambucil resistance by ethacrynic acid in a B-CLL patient.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Drug Resistance; Ethacrynic Acid | 1993 |
Selective toxicity of ethacrynic acid towards lymphocytes of chronic lymphocytic leukemia in vitro.
Topics: Cell Survival; Dose-Response Relationship, Drug; Ethacrynic Acid; Humans; In Vitro Techniques; Leuke | 1992 |