ethacrynic acid has been researched along with Adverse Drug Event in 9 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Weston, JK | 1 |
| Uetrecht, J | 1 |
| Marlowe, FI | 1 |
| Jongkees, LB | 1 |
| Gray, GM | 1 |
| Uhlír, O | 1 |
1 review available for ethacrynic acid and Adverse Drug Event
| Article | Year |
|---|---|
Drugs, malnutrition, and carbohydrate absorption.
Topics: Aged; Animals; Atropine; Carbohydrate Metabolism; Clinical Enzyme Tests; Colchicine; Cortisone; Diet | 1973 |
8 other studies available for ethacrynic acid and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Activation of inflammasomes by agents causing idiosyncratic skin reactions: a possible biomarker.
Topics: Biomarkers; Cell Line; Dimethyl Fumarate; Dose-Response Relationship, Drug; Drug-Related Side Effect | 2014 |
Ototoxic agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Aspirin; Child; Drug-Related Side Effects and Adver | 1978 |
[Deafness as a result of the use of drugs].
Topics: Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Ethacryni | 1974 |
Drug-induced deafness.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Et | 1973 |
[Results of monitoring of adverse drug effects in various European countries in the years 1967-1969].
Topics: Aerosols; Appetite Depressants; Chloramphenicol; Contraceptives, Oral; Czechoslovakia; Dextrans; Dru | 1970 |