ethacrynic acid has been researched along with Adenocarcinoma in 4 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since GST inhibitors such as ethacrynic acid are suggested to induce apoptosis in some cell lines, the effect of benastatin A on the survival of mouse colon 26 adenocarcinoma cells was compared with that of ethacrynic acid." | 3.70 | Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A. ( Aoyagi, T; Hayakari, M; Ishikawa, T; Kakizaki, I; Ookawa, K; Tsuchida, S, 2000) |
| " Addition of ethacrynic acid (3 micrograms ml-1) to treatment of the cell lines with melphalan or with cisplatin did not alter the dose-response curves to these agents." | 1.28 | A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines. ( Rhodes, T; Twentyman, PR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, FH | 1 |
| Chiang, YR | 1 |
| Tseng, AL | 1 |
| Sung, YC | 1 |
| Lu, J | 1 |
| Huang, MC | 1 |
| Ma, N | 1 |
| Lee, HC | 1 |
| Kakizaki, I | 1 |
| Ookawa, K | 1 |
| Ishikawa, T | 1 |
| Hayakari, M | 1 |
| Aoyagi, T | 1 |
| Tsuchida, S | 1 |
| Rhodes, T | 1 |
| Twentyman, PR | 1 |
| Murphy, GP | 1 |
| Mirand, EA | 1 |
| Johnston, GS | 1 |
| Gibbons, RP | 1 |
| Schirmer, HK | 1 |
| Scott, WW | 1 |
4 other studies available for ethacrynic acid and Adenocarcinoma
| Article | Year |
|---|---|
Functional Module Connectivity Map (FMCM): a framework for searching repurposed drug compounds for systems treatment of cancer and an application to colorectal adenocarcinoma.
Topics: Adenocarcinoma; Algorithms; Colorectal Neoplasms; Drug Repositioning; Epistasis, Genetic; Ethacrynic | 2014 |
Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A.
Topics: Adenocarcinoma; Animals; Apoptosis; Benz(a)Anthracenes; Cell Cycle; Cell Survival; Colonic Neoplasms | 2000 |
A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Dr | 1992 |
Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; El | 1968 |