ethacrynic acid has been researched along with Adenocarcinoma of Lung in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Adenocarcinoma of Lung: A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells." | 5.91 | Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023) |
| "Ethacrynic acid (ECA) is a loop diuretic that inhibits the EMT process in lung cancer cells." | 1.91 | Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway. ( Bae Rho, S; Hoon Lee, C; Huy Phùng, H; Hyeon Kim, Y; Ji Kim, E; Ji Kim, H; Jin Kang, G; Jung Byun, H; Kim, B; Kyung Han, H; Kyung Park, M; Lee, H; Lee, K; Minh Nguyen, T; Rahman, M; Yu, L; Yun Jang, J, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, L | 1 |
| Ji Kim, H | 1 |
| Kim, B | 1 |
| Jung Byun, H | 1 |
| Minh Nguyen, T | 1 |
| Ji Kim, E | 1 |
| Huy Phùng, H | 1 |
| Hyeon Kim, Y | 1 |
| Rahman, M | 1 |
| Yun Jang, J | 1 |
| Bae Rho, S | 1 |
| Jin Kang, G | 1 |
| Lee, H | 1 |
| Lee, K | 1 |
| Kyung Han, H | 1 |
| Kyung Park, M | 1 |
| Hoon Lee, C | 1 |
1 other study available for ethacrynic acid and Adenocarcinoma of Lung
| Article | Year |
|---|---|
Ethacrynic acid suppresses B7-H4 expression involved in epithelial-mesenchymal transition of lung adenocarcinoma cells via inhibiting STAT3 pathway.
Topics: Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; | 2023 |