ethacrynic acid has been researched along with Acute Promyelocytic Leukemia in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, R | 1 |
| Li, C | 1 |
| Song, D | 1 |
| Zhao, G | 1 |
| Zhao, L | 1 |
| Jing, Y | 1 |
| Makishima, M | 1 |
| Honma, Y | 1 |
2 other studies available for ethacrynic acid and Acute Promyelocytic Leukemia
| Article | Year |
|---|---|
Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition.
Topics: Acetylcysteine; Apoptosis; Caspases; Catalase; Cell Growth Processes; Ethacrynic Acid; Glutathione S | 2007 |
Ethacrynic acid and 1 alpha,25-dihydroxyvitamin D3 cooperatively inhibit proliferation and induce differentiation of human myeloid leukemia cells.
Topics: Calcitriol; Cell Differentiation; Cell Division; Diuretics; Drug Synergism; Ethacrynic Acid; HL-60 C | 1996 |