ethacrynic acid has been researched along with Acidosis in 15 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Veverimer is not systemically absorbed, so potential drug-drug interactions (DDIs) are limited to effects on the absorption of other oral drugs through binding to veverimer in the gastrointestinal tract or increases in gastric pH caused by veverimer binding to hydrochloric acid." | 3.01 | Assessment of the Potential for Veverimer Drug-Drug Interactions. ( Biyani, K; Guttendorf, R; Klaerner, G; Lee, A; Li, E; Mathur, V; Parsell, D; Shao, J; Stasiv, Y; Tabakman, S; Tsao, L; Wu, YS, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Parsell, D | 1 |
| Shao, J | 1 |
| Guttendorf, R | 1 |
| Mathur, V | 1 |
| Li, E | 1 |
| Wu, YS | 1 |
| Tsao, L | 1 |
| Tabakman, S | 1 |
| Stasiv, Y | 1 |
| Lee, A | 1 |
| Biyani, K | 1 |
| Klaerner, G | 1 |
| CANNON, PJ | 1 |
| HEINEMANN, HO | 1 |
| STASON, WB | 1 |
| LARAGH, JH | 1 |
| BEYER, KH | 1 |
| BAER, JE | 1 |
| MICHAELSON, JK | 1 |
| RUSSO, HF | 1 |
| Hulter, HN | 1 |
| Toto, RD | 1 |
| Sebastian, A | 1 |
| Mackie, S | 1 |
| Cooke, CR | 1 |
| Wilson, TE | 1 |
| Melby, JC | 1 |
| Gremske, D | 1 |
| Brien, G | 1 |
| Bick, C | 1 |
| Nimmergut, S | 1 |
| Levin, DL | 1 |
| Chou, SY | 2 |
| Ferder, LF | 1 |
| Liebman, PH | 1 |
| Porush, JG | 2 |
| Veverbrants, E | 1 |
| Chazan, JA | 1 |
| Garella, S | 1 |
| Adrogué, HJ | 1 |
| Brensilver, J | 1 |
| Madias, NE | 1 |
| Mathisen, O | 2 |
| Monclair, T | 2 |
| Holdaas, H | 1 |
| Kiil, F | 2 |
| Raeder, M | 1 |
| Yoshida, T | 1 |
| Slater, PA | 1 |
| Flombaum, CD | 1 |
| Shafi, T | 1 |
| Fein, PA | 1 |
| Halperin, ML | 1 |
| Chen, CB | 1 |
| Glassman, VP | 1 |
| Safirstein, R | 1 |
| DiScala, VA | 1 |
| Yamauchi, M | 1 |
1 review available for ethacrynic acid and Acidosis
| Article | Year |
|---|---|
Substrate metabolism and renal function.
Topics: Absorption; Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Deamination; Energy Metabolism; Ethac | 1976 |
1 trial available for ethacrynic acid and Acidosis
| Article | Year |
|---|---|
Assessment of the Potential for Veverimer Drug-Drug Interactions.
Topics: Absorption, Physicochemical; Acidosis; Administration, Oral; Adolescent; Adult; Aspirin; Cross-Over | 2021 |
13 other studies available for ethacrynic acid and Acidosis
| Article | Year |
|---|---|
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors; | 1965 |
RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID: A PHENOXYACETIC SALURETIC-DIURETIC AGENT.
Topics: Acidosis; Alkalosis; Chlorothiazide; Creatine; Creatinine; Diuretics; Dogs; Ethacrynic Acid; Hydroch | 1965 |
Effect of extracellular fluid volume depletion on renal regulation of acid-base and potassium equilibrium during prolonged mineral acid administration.
Topics: Acid-Base Equilibrium; Acidosis; Aldosterone; Animals; Bicarbonates; Chlorides; Dogs; Ethacrynic Aci | 1984 |
[Distal form of renal tubular acidosis and nephrolithiasis].
Topics: Acidosis; Ethacrynic Acid; Humans; Hydrochlorothiazide; Kidney Calculi; Kidney Tubules; Kidney Tubul | 1980 |
The effect of the plasma bicarbonate level on proximal tubule sodium reabsorption in NH4Cl-loaded dogs.
Topics: Acidosis; Ammonium Chloride; Animals; Bicarbonates; Body Weight; Chlorides; Diuresis; Dogs; Ethacryn | 1976 |
Ammonium excretion in response to acid loads: effect of metabolic alkalosis and cation depletion.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Bicarbonates; Chlorides; Dogs; Electrolytes; Ethacrynic Acid; | 1977 |
Changes in the plasma anion gap during chronic metabolic acid-base disturbances.
Topics: Acidosis; Alkalosis; Animals; Blood; Blood Proteins; Chlorides; Dogs; Ethacrynic Acid; Extracellular | 1978 |
Bicarbonate as mediator of proximal tubular NaCl reabsorption and glomerulotubular balance.
Topics: Absorption; Acetazolamide; Acidosis; Animals; Bicarbonates; Carbonic Anhydrases; Dogs; Dose-Response | 1978 |
Coupling of NaHCO3 and NaCl reabsorption in dog kidneys during changes in plasma PCO2.
Topics: Acidosis; Animals; Bicarbonates; Carbon Dioxide; Dogs; Ethacrynic Acid; Female; Glomerular Filtratio | 1979 |
Effects of acetazolamide on proximal tubule C1, Na, and HCO3 transport in normal and acidotic dogs during distal blockade.
Topics: Acetazolamide; Acidosis; Ammonium Chloride; Animals; Bicarbonates; Chlorides; Chlorothiazide; Dogs; | 1977 |
Substrate utilization by the distal nephron in dogs with chronic metabolic acidosis: studies with ethacrynic acid.
Topics: Acidosis; Adenosine Triphosphate; Animals; Carbon Dioxide; Dogs; Ethacrynic Acid; Female; Hydrogen-I | 1985 |
Effects of metabolic acidosis on proximal tubule ion reabsorption in dog kidney.
Topics: Acid-Base Equilibrium; Acidosis; Ammonium Chloride; Animals; Body Weight; Calcium; Chlorothiazide; D | 1974 |
[New diuretics--ethacrynic acid].
Topics: Acidosis; Animals; Ethacrynic Acid; Haplorhini; Humans; Hypokalemia | 1970 |