etazolate has been researched along with Disease Models, Animal in 7 studies
Etazolate: A potent phosphodiesterase inhibitor proposed as an antipsychotic agent.
etazolate : A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Etazolate is a selective phosphodiesterase-4 inhibitor that is specific for cAMP." | 5.46 | Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2017) |
| "Demyelination is a well-known pathological process in CNS disorders such as multiple sclerosis (MS)." | 1.62 | Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis. ( Carrete, A; Jafarian-Tehrani, M; Meffre, D; Padilla-Ferrer, A; Simon, A, 2021) |
| "Etazolate treatment, on the other hand, led to prevention of changes in these oxidative stress biomarkers (GSH, GSSG, GPx and TBARS), BDNF levels, and histones acetylation." | 1.51 | Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2019) |
| "Etazolate is a selective phosphodiesterase-4 inhibitor that is specific for cAMP." | 1.46 | Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2017) |
| "Etazolate (ETZ) is a new generation PDE4 inhibitor with encouraging safety and tolerance profiles." | 1.46 | Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model. ( Bhatt, S; Jindal, A; Mahesh, R; Pandey, D, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Carrete, A | 1 |
| Padilla-Ferrer, A | 1 |
| Simon, A | 1 |
| Meffre, D | 1 |
| Jafarian-Tehrani, M | 1 |
| Alzoubi, KH | 2 |
| Al Subeh, ZY | 2 |
| Khabour, OF | 2 |
| Guo, J | 1 |
| Lin, P | 1 |
| Zhao, X | 1 |
| Zhang, J | 1 |
| Wei, X | 1 |
| Wang, Q | 1 |
| Wang, C | 1 |
| Jindal, A | 1 |
| Mahesh, R | 1 |
| Bhatt, S | 1 |
| Pandey, D | 1 |
7 other studies available for etazolate and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Etazolate; Mice; Mice, Inbred C5 | 2021 |
Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; D | 2017 |
Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; B | 2019 |
Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic AMP Response E | 2014 |
Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain Injuries, Traumatic; Corticost | 2017 |