etazolate has been researched along with Depression in 8 studies
Etazolate: A potent phosphodiesterase inhibitor proposed as an antipsychotic agent.
etazolate : A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD)." | 7.88 | Beneficial effect of etazolate on depression-like behavior and, learning, and memory impairment in a model of Parkinson's disease. ( Abuirmeileh, AN; Alzoubi, KH; Mokhemer, E, 2018) |
| "Etazolate is a selective phosphodiesterase-4 inhibitor that is specific for cAMP." | 5.46 | Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2017) |
| "The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD)." | 3.88 | Beneficial effect of etazolate on depression-like behavior and, learning, and memory impairment in a model of Parkinson's disease. ( Abuirmeileh, AN; Alzoubi, KH; Mokhemer, E, 2018) |
| " Our earlier studies demonstrated that etazolate produced antidepressant-like effects in behavioral despair models of depression; however, the potential role of etazolate on behavior and morphological changes in the hippocampus region along with its underlying mechanism(s) following OBX has not been adequately addressed." | 3.81 | Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy. ( Bhatt, S; Jindal, A; Mahesh, R, 2015) |
| "Etazolate treatment, on the other hand, led to prevention of changes in these oxidative stress biomarkers (GSH, GSSG, GPx and TBARS), BDNF levels, and histones acetylation." | 1.51 | Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2019) |
| "Etazolate is a selective phosphodiesterase-4 inhibitor that is specific for cAMP." | 1.46 | Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder. ( Al Subeh, ZY; Alzoubi, KH; Khabour, OF, 2017) |
| "Etazolate (ETZ) is a new generation PDE4 inhibitor with encouraging safety and tolerance profiles." | 1.46 | Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model. ( Bhatt, S; Jindal, A; Mahesh, R; Pandey, D, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alzoubi, KH | 3 |
| Al Subeh, ZY | 2 |
| Khabour, OF | 2 |
| Mokhemer, E | 1 |
| Abuirmeileh, AN | 1 |
| Guo, J | 1 |
| Lin, P | 2 |
| Zhao, X | 2 |
| Zhang, J | 2 |
| Wei, X | 1 |
| Wang, Q | 2 |
| Wang, C | 2 |
| Lu, Y | 1 |
| Pan, T | 1 |
| Liu, A | 1 |
| Zhou, W | 1 |
| Zhang, HT | 1 |
| Jindal, A | 3 |
| Mahesh, R | 3 |
| Bhatt, S | 3 |
| Pandey, D | 2 |
| Gautam, B | 1 |
8 other studies available for etazolate and Depression