etanidazole has been researched along with Experimental Neoplasms in 42 studies
Etanidazole: A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.
etanidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The intra-cellular uptake of the weakly basic radiosensitiser pimonidazole (PIMO) was determined as a function of the pigmentation of Na11+ human melanotic melanoma cells in vitro." | 7.68 | Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole. ( el Gamoussi, R; Guichard, M; Prade, M; Stratford, IJ; Threadgill, MD, 1993) |
| "The effect of treatments with the hypoxic cell radiosensitizers misonidazole (MISO), SR-2508, RSU-1069, and with the radioprotector WR-2721 on spontaneously disseminated Lewis lung carcinoma (LLC) and B16 melanoma (B16M) was investigated." | 7.67 | Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. ( Chapman, JD; Kanclerz, A, 1988) |
| "The intra-cellular uptake of the weakly basic radiosensitiser pimonidazole (PIMO) was determined as a function of the pigmentation of Na11+ human melanotic melanoma cells in vitro." | 3.68 | Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole. ( el Gamoussi, R; Guichard, M; Prade, M; Stratford, IJ; Threadgill, MD, 1993) |
| "The effect of treatments with the hypoxic cell radiosensitizers misonidazole (MISO), SR-2508, RSU-1069, and with the radioprotector WR-2721 on spontaneously disseminated Lewis lung carcinoma (LLC) and B16 melanoma (B16M) was investigated." | 3.67 | Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. ( Chapman, JD; Kanclerz, A, 1988) |
| "Tirapazamine (TPZ) is a hypoxia-selective bioreductive drug currently in Phases II and III clinical trials with both radiotherapy and chemotherapy." | 1.30 | Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. ( Brown, JM; Dorie, MJ; Menke, DR; Siim, BG, 1997) |
| "01) less toxic than RK-28 at this dose, as reflected in a lower increase in the brain glucose level (0." | 1.29 | Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers. ( Streffer, C; Tamulevicius, P, 1994) |
| " In addition, the distribution of sensitizers in different areas of individual tumors, as well as several normal tissues were measured after intravenous dosing of 0." | 1.27 | A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice. ( Minchinton, AI; Stratford, MR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (57.14) | 18.7374 |
| 1990's | 14 (33.33) | 18.2507 |
| 2000's | 2 (4.76) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, R | 1 |
| Apte, S | 1 |
| Vilalta, M | 1 |
| Subbarayan, M | 1 |
| Miao, Z | 1 |
| Chin, FT | 1 |
| Graves, EE | 1 |
| Kirjavainen, A | 1 |
| Forsback, S | 1 |
| Grönroos, TJ | 1 |
| Haavisto, L | 1 |
| Haaparanta, M | 1 |
| Solin, O | 1 |
| Barthel, H | 1 |
| Wilson, H | 1 |
| Collingridge, DR | 1 |
| Brown, G | 1 |
| Osman, S | 1 |
| Luthra, SK | 1 |
| Brady, F | 1 |
| Workman, P | 2 |
| Price, PM | 1 |
| Aboagye, EO | 1 |
| Hirst, DG | 3 |
| Hazlehurst, JL | 2 |
| Brown, JM | 9 |
| Ono, K | 1 |
| Takahashi, M | 2 |
| Nishidai, T | 1 |
| Shibamoto, Y | 3 |
| Abe, M | 2 |
| Moldenhauer, H | 1 |
| Rose, H | 1 |
| Saul, G | 1 |
| Wolf, G | 1 |
| Kehrberg, G | 1 |
| Yu, NY | 3 |
| Tamulevicius, P | 2 |
| Streffer, C | 2 |
| Blanke, G | 1 |
| Luscher, G | 1 |
| Horsman, MR | 1 |
| Williams, MV | 1 |
| Denekamp, J | 1 |
| Fowler, JF | 1 |
| Brown, DM | 1 |
| Lee, WW | 1 |
| Oya, N | 1 |
| Shibata, T | 1 |
| Sasai, K | 2 |
| Sugiyama, T | 1 |
| el Gamoussi, R | 1 |
| Threadgill, MD | 1 |
| Prade, M | 1 |
| Stratford, IJ | 2 |
| Guichard, M | 3 |
| Murayama, C | 4 |
| Suzuki, A | 3 |
| Sato, C | 2 |
| Tanabe, Y | 3 |
| Shoji, T | 2 |
| Miyata, Y | 3 |
| Nishio, A | 1 |
| Suzuki, T | 3 |
| Sakaguchi, M | 3 |
| Mori, T | 5 |
| Laughlin, KM | 1 |
| Evans, SM | 2 |
| Jenkins, WT | 2 |
| Tracy, M | 1 |
| Chan, CY | 1 |
| Lord, EM | 2 |
| Koch, CJ | 2 |
| Siim, BG | 1 |
| Menke, DR | 1 |
| Dorie, MJ | 1 |
| Shapiro, M | 1 |
| Rasey, JS | 1 |
| Hofstrand, PD | 1 |
| Chin, LK | 1 |
| Tewson, TJ | 1 |
| Fenton, BM | 1 |
| Paoni, SF | 1 |
| Wallen, CA | 2 |
| Moore, SK | 1 |
| Wheeler, KT | 2 |
| Stone, HB | 2 |
| Hirst, VK | 1 |
| Cribbs, R | 1 |
| Luu, YH | 2 |
| Nishimoto, S | 1 |
| Shimokawa, K | 1 |
| Hisanaga, Y | 1 |
| Kitakabu, Y | 1 |
| Zhou, L | 1 |
| Wang, J | 1 |
| Kagiya, T | 1 |
| Wong, KH | 1 |
| Coldwell, DM | 1 |
| Huff, J | 1 |
| Marcellus, H | 1 |
| Coldwell, SG | 1 |
| Lespinasse, F | 2 |
| Thomas, C | 1 |
| Bonnay, M | 1 |
| Malaise, EP | 2 |
| Kramer, RA | 1 |
| Soble, M | 1 |
| Howes, AE | 1 |
| Montoya, VP | 1 |
| Tanaka, N | 1 |
| Kanclerz, A | 1 |
| Chapman, JD | 1 |
| Adams, GE | 1 |
| Hill, RP | 1 |
| Lam, KN | 1 |
| Minchinton, AI | 1 |
| Stratford, MR | 1 |
| Biscay, P | 1 |
| Honess, DJ | 1 |
| Wasserman, TH | 1 |
| Ward, R | 1 |
| Bleehen, NM | 1 |
5 reviews available for etanidazole and Experimental Neoplasms
| Article | Year |
|---|---|
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophospha | 1984 |
[Radiosensitizer: hypoxic cell radiosensitizer].
Topics: Animals; DNA; Dogs; Etanidazole; Hydroxamic Acids; Hydroxylation; Intercalating Agents; Lethal Dose | 1989 |
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neopl | 1986 |
Sensitizers and radiation dose fractionation: results and interpretations.
Topics: Animals; Combined Modality Therapy; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroi | 1986 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione | 1985 |
2 trials available for etanidazole and Experimental Neoplasms
| Article | Year |
|---|---|
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; | 1984 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione | 1985 |
36 other studies available for etanidazole and Experimental Neoplasms
| Article | Year |
|---|---|
18F-EF5 PET Is Predictive of Response to Fractionated Radiotherapy in Preclinical Tumor Models.
Topics: Adenocarcinoma; Animals; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; E | 2015 |
Electrophilic addition of chlorine monofluoride for PET tracers.
Topics: Animals; Chlorides; Etanidazole; Fluorides; Hydrocarbons, Fluorinated; Male; Mice; Mice, Nude; Neopl | 2013 |
In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Etanidazole; Fibrosarcoma; Fluorine Radioisotopes; Mice; Mi | 2004 |
Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Mice; Mice | 1984 |
[Recent advances in hypoxic cell radiosensitizer].
Topics: Animals; Cells, Cultured; Etanidazole; Maleates; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Ex | 1983 |
Clinical trials of radiosensitizers: what should we expect?
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Evaluati | 1984 |
Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report.
Topics: Animals; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etanidazole; Female; Mice | 1984 |
Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Etanidazole; Glutathione; Maleates; Meth | 1984 |
The effects of radiosensitizers on intermediary metabolism in vivo.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenocarcinoma; Animals; Dihydroxyacetone Phosphate; Etanidazo | 1984 |
The effect of timing on chemosensitization by clinical levels of SR-2508.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Etanida | 1984 |
SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use.
Topics: Animals; Carcinoma; Cell Line; Central Nervous System; Cricetinae; Dogs; Etanidazole; Female; In Vit | 1981 |
Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses.
Topics: Aerobiosis; Animals; Cell Line; Chromosome Aberrations; Dose-Response Relationship, Radiation; Etani | 1994 |
Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers.
Topics: Adenosine Triphosphate; Animals; Brain; Etanidazole; Glucose; Male; Mice; Mice, Inbred C57BL; Misoni | 1994 |
Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole.
Topics: Animals; Autoradiography; Cell Line; Etanidazole; Humans; Melanins; Melanoma; Mice; Mice, Nude; Neop | 1993 |
Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole(RP-343).
Topics: Animals; Cell Hypoxia; Cell Survival; Dogs; Dose-Response Relationship, Drug; Etanidazole; Female; I | 1993 |
Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.
Topics: Animals; Antineoplastic Agents; Etanidazole; Hydrocarbons, Fluorinated; Hypoxia; Mice; Mice, Inbred | 1996 |
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; DNA; DNA Damage; Etanidazole; Humans; Hydrocarbons, Fl | 1997 |
Evaluation of the concept of "hypoxic fraction" as a descriptor of tumor oxygenation status.
Topics: Animals; Benzimidazoles; Cell Hypoxia; Cell Survival; Etanidazole; Fluorescent Dyes; Glioma; Humans; | 1997 |
Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Cell Hypoxia; Chromatography, High Pressure Liquid; Con | 1999 |
Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.
Topics: Animals; Borates; Calcium Compounds; Disease Models, Animal; Etanidazole; Female; Hydrocarbons, Fluo | 2001 |
Radiosensitization by 2-nitroimidazole nucleoside analog RP-170: radiosensitizing effects under both intravenous and oral administration.
Topics: Administration, Oral; Animals; Combined Modality Therapy; Etanidazole; Female; Injections, Intraveno | 1992 |
Modification of alkylating agent induced cell kill by 2-nitroimidazoles in unclamped and clamped SC 9L tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Survival; Cyclophosphami | 1992 |
A comparison of radiosensitization by etanidazole and pimonidazole in mouse tumors.
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; Male; Mice; Mice, Inbred BALB C; Mic | 1991 |
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer.
Topics: Animals; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etanidazole; Female; Mice | 1991 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplant | 1990 |
Tumour radiosensitization by clofibrate and its analogs: possible mechanisms.
Topics: Animals; Bezafibrate; Clofibrate; Combined Modality Therapy; Etanidazole; Female; Hypoxia; Mice; Mic | 1990 |
Experimental intra-arterial administration of SR-2508 in the rabbit V2 carcinoma model.
Topics: Animals; Etanidazole; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Neoplasms, Experiment | 1989 |
Ro 03-8799: preferential relative uptake in human tumor xenografts compared to a murine tumor: comparison with SR-2508.
Topics: Animals; Cell Line; Etanidazole; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Expe | 1989 |
The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508.
Topics: Animals; Buthionine Sulfoximine; Etanidazole; Glutathione; Methionine Sulfoximine; Mice; Mice, Inbre | 1989 |
Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170).
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; In Vitro Techniques; Mice; Mice, Inb | 1989 |
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonida | 1988 |
Sensitization by SR-2508 plus Ro 03-8799.
Topics: Animals; Combined Modality Therapy; Drug Combinations; Etanidazole; Male; Mice; Mice, Inbred BALB C; | 1986 |
A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice.
Topics: Animals; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensit | 1986 |
SR-2508 plus buthionine sulfoximine or SR-2508 alone: effects on the radiation response and the glutathione content of a human tumor xenograft.
Topics: Buthionine Sulfoximine; Cell Survival; Cysteine; Etanidazole; Glutathione; Humans; Methionine Sulfox | 1987 |
Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Etanidazole; Female; Mice; Mice, Inbred BALB C; N | 1988 |
[Development of new hypoxic cell radiosensitizer in Japan].
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Etanidazole; Hydroxamic Acids; Mice; Misonidazole; Neop | 1988 |