etanidazole has been researched along with Carcinoma, Epidermoid in 19 studies
Etanidazole: A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.
etanidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0 g/m2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 micrograms/g in bladder cancer and 65 micrograms/g in cervical cancer." | 3.67 | Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: evidence of diffusion from urine. ( abd el Baki, H; Akoush, H; Awwad, HK; el Badawy, S; el Moneim Osman, A; Fairchild, K; Zaghloul, M, 1989) |
| "The aim of the study was to evaluate the efficacy and toxicity of Etanidazole, a hypoxic cell sensitizer, combined with radiotherapy in the treatment of head and neck squamous cell carcinoma." | 2.68 | Results of a European randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas. ( Bey, P; Brisgand, D; Busutti, L; Chassagne, D; Chavaudra, J; Cionini, L; Eschwège, F; Guerra, M; Hill, C; Malaise, EP; N'Guyen, T; Romanini, A; Sancho-Garnier, H, 1997) |
| "Etanidazole was given at a dose of 2 g/m2, 3 times per week, for a total of 30-34 g/m2." | 2.67 | First analysis of tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas. ( Charreau, I; Chassagne, D; Eschwege, F; Malaise, EP; Sancho-Garnier, H, 1992) |
| " Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter." | 1.29 | Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice. ( Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y, 1994) |
| " Pharmacokinetic studies were performed in six cats." | 1.28 | Technique, pharmacokinetics, toxicity, and efficacy of intratumoral etanidazole and radiotherapy for treatment of spontaneous feline oral squamous cell carcinoma. ( Brown, DQ; Curran, WJ; Evans, SM; Hanks, G; Helfand, S; LaCreta, F; VanWinkle, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aguilera, TA | 1 |
| Giaccia, AJ | 1 |
| Le, QT | 1 |
| Evans, SM | 3 |
| Du, KL | 1 |
| Chalian, AA | 2 |
| Mick, R | 1 |
| Zhang, PJ | 1 |
| Hahn, SM | 1 |
| Quon, H | 1 |
| Lustig, R | 1 |
| Weinstein, GS | 1 |
| Koch, CJ | 2 |
| Lee, DJ | 4 |
| Cosmatos, D | 3 |
| Marcial, VA | 2 |
| Fu, KK | 3 |
| Rotman, M | 2 |
| Cooper, JS | 3 |
| Ortiz, HG | 1 |
| Beitler, JJ | 1 |
| Abrams, RA | 1 |
| Curran, WJ | 2 |
| Buswell, L | 1 |
| Recht, A | 1 |
| Clark, J | 1 |
| Ravikumar, T | 1 |
| Busse, PM | 1 |
| Coleman, CN | 2 |
| Shibata, T | 1 |
| Shibamoto, Y | 2 |
| Oya, N | 1 |
| Sasai, K | 2 |
| Murata, R | 1 |
| Ishigaki, T | 1 |
| Abe, M | 2 |
| Iwai, H | 1 |
| Matsuno, E | 1 |
| Ono, K | 1 |
| Akuta, K | 1 |
| Masunaga, S | 1 |
| Kinashi, Y | 1 |
| Suzuki, M | 1 |
| Eschwège, F | 3 |
| Sancho-Garnier, H | 3 |
| Chassagne, D | 3 |
| Brisgand, D | 1 |
| Guerra, M | 1 |
| Malaise, EP | 3 |
| Bey, P | 1 |
| Busutti, L | 1 |
| Cionini, L | 1 |
| N'Guyen, T | 1 |
| Romanini, A | 1 |
| Chavaudra, J | 1 |
| Hill, C | 1 |
| Lee, WR | 1 |
| Berkey, B | 2 |
| Marcial, V | 3 |
| Vikram, B | 1 |
| Coia, LR | 1 |
| Ortiz, H | 1 |
| Hahn, S | 1 |
| Pook, DR | 1 |
| Jenkins, WT | 1 |
| Zhang, P | 1 |
| Stevens, C | 1 |
| Weber, R | 1 |
| Weinstein, G | 1 |
| Benjamin, I | 1 |
| Mirza, N | 1 |
| Morgan, M | 1 |
| Rubin, S | 1 |
| McKenna, WG | 1 |
| Lord, EM | 1 |
| Vukovic, V | 1 |
| Haugland, HK | 1 |
| Nicklee, T | 1 |
| Morrison, AJ | 1 |
| Hedley, DW | 1 |
| Phillips, TL | 1 |
| Davis, LW | 1 |
| Wasserman, TH | 2 |
| Rubin, P | 1 |
| Charreau, I | 2 |
| LaCreta, F | 1 |
| Helfand, S | 1 |
| VanWinkle, T | 1 |
| Brown, DQ | 1 |
| Hanks, G | 1 |
| Coleman, N | 1 |
| Phillips, T | 1 |
| Davis, L | 1 |
| Stetz, J | 1 |
| Awwad, HK | 1 |
| el Badawy, S | 1 |
| abd el Baki, H | 1 |
| Zaghloul, M | 1 |
| el Moneim Osman, A | 1 |
| Akoush, H | 1 |
| Fairchild, K | 1 |
9 trials available for etanidazole and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas.
Topics: Carcinoma, Squamous Cell; Etanidazole; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; N | 1995 |
Combined-modality therapy of esophageal cancer with radiotherapy, etanidazole, and cisplatin-fluorouracil, with or without surgery: neurotoxicity, other toxicities and outcome.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel | 1994 |
Results of a European randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Disease-Free Survival; Drug Administration | 1997 |
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
Topics: Analysis of Variance; Anemia; Antineoplastic Agents; Carcinoma, Squamous Cell; Etanidazole; Female; | 1998 |
Detection of hypoxia in human squamous cell carcinoma by EF5 binding.
Topics: Adult; Aged; Antineoplastic Agents; Binding Sites; Carcinoma, Squamous Cell; Cell Hypoxia; Etanidazo | 2000 |
Logistics in designing clinical trials for etanidazole (SR 2508): an RTOG experience.
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Etanidazole; Head and Neck Neoplasms; Humans; N | 1992 |
First analysis of tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas.
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Etanidazole; Female; Head and Neck Neoplasms; H | 1992 |
Progress report of a phase II and a phase III trial with etanidazole (SR-2508): a multicentre European study.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation | 1991 |
Clinical trials with etanidazole (SR-2508) by the Radiation Therapy Oncology Group (RTOG).
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation; Etanidazole; Head and Neck Neo | 1991 |
10 other studies available for etanidazole and Carcinoma, Epidermoid
| Article | Year |
|---|---|
The end of the hypoxic EPOch.
Topics: Anemia; Blood Transfusion; Carcinoma, Squamous Cell; Cell Hypoxia; Clinical Trials as Topic; Erythro | 2015 |
Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell | 2007 |
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.
Topics: Aged; Carcinoma, Squamous Cell; Cell Hypoxia; Etanidazole; Female; Fluorescent Antibody Technique; H | 2007 |
Comparison of radiosensitizing effect of KU-2285 and SR-2508 at low drug concentrations and doses.
Topics: Animals; Carcinoma, Squamous Cell; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Fem | 1994 |
Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice.
Topics: Animals; Carcinoma, Squamous Cell; Etanidazole; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred I | 1994 |
The radiosensitizing effects of hypoxic cell sensitizer on SCCVII tumors in mice evaluated by highly accurate colony formation assay assisted by microcomputer.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Survival; Etanidazole; Male; Mice; Mice, Inbre | 1996 |
Validation of the RTOG recursive partitioning classification for head and neck tumors.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Databases, Factual; Etanidazole; Head and Neck Neop | 2001 |
Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Etanidazole; Female; Humans; Hyd | 2001 |
Technique, pharmacokinetics, toxicity, and efficacy of intratumoral etanidazole and radiotherapy for treatment of spontaneous feline oral squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Combined Modality Therapy; Etanidazole; Mouth | 1991 |
Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: evidence of diffusion from urine.
Topics: Carcinoma, Squamous Cell; Diffusion; Etanidazole; Female; Humans; Nitroimidazoles; Radiation-Sensiti | 1989 |