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etanidazole and Astrocytoma

etanidazole has been researched along with Astrocytoma in 2 studies

Etanidazole: A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.
etanidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma."9.10A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. ( Barnes, P; Billett, AL; Coleman, CN; Dutton, SC; Goumnerova, L; Kieran, M; Marcus, KJ; Pomeroy, SL; Tarbell, NJ, 2003)
"To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma."5.10A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. ( Barnes, P; Billett, AL; Coleman, CN; Dutton, SC; Goumnerova, L; Kieran, M; Marcus, KJ; Pomeroy, SL; Tarbell, NJ, 2003)
"To report the survival results from a previous Phase I study of etanidazole (ETA) and radiotherapy in patients with glioblastoma multiforme (GBM n = 50) or anaplastic astrocytoma (AA n = 19) and examine survival according to age, Karnofsky performance status (KPS), and implant status."5.08Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma. ( Alexander, E; Black, PM; Chang, EL; Coleman, CN; Loeffler, JS; Riese, NE; Wen, PY, 1998)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marcus, KJ1
Dutton, SC1
Barnes, P1
Coleman, CN2
Pomeroy, SL1
Goumnerova, L1
Billett, AL1
Kieran, M1
Tarbell, NJ1
Chang, EL1
Loeffler, JS1
Riese, NE1
Wen, PY1
Alexander, E1
Black, PM1

Trials

2 trials available for etanidazole and Astrocytoma

ArticleYear
A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma.
    International journal of radiation oncology, biology, physics, 2003, Apr-01, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Stem Neoplasms; Child; Child, Preschool

2003
Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma.
    International journal of radiation oncology, biology, physics, 1998, Jan-01, Volume: 40, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brachytherapy; Brain Neoplasms; Etanidazole; Feasib

1998