etanidazole has been researched along with Astrocytoma, Grade IV in 5 studies
Etanidazole: A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.
etanidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma." | 9.10 | A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. ( Barnes, P; Billett, AL; Coleman, CN; Dutton, SC; Goumnerova, L; Kieran, M; Marcus, KJ; Pomeroy, SL; Tarbell, NJ, 2003) |
| "To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma." | 5.10 | A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. ( Barnes, P; Billett, AL; Coleman, CN; Dutton, SC; Goumnerova, L; Kieran, M; Marcus, KJ; Pomeroy, SL; Tarbell, NJ, 2003) |
| "To report the survival results from a previous Phase I study of etanidazole (ETA) and radiotherapy in patients with glioblastoma multiforme (GBM n = 50) or anaplastic astrocytoma (AA n = 19) and examine survival according to age, Karnofsky performance status (KPS), and implant status." | 5.08 | Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma. ( Alexander, E; Black, PM; Chang, EL; Coleman, CN; Loeffler, JS; Riese, NE; Wen, PY, 1998) |
| "Tissues from six human brain tumors were assessed." | 1.35 | Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. ( Dilling, T; Evans, SM; Hahn, SM; Jenkins, KW; Jenkins, WT; Judkins, A; Judy, KD; Koch, CJ; Schrlau, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, SM | 2 |
| Jenkins, KW | 1 |
| Jenkins, WT | 1 |
| Dilling, T | 1 |
| Judy, KD | 2 |
| Schrlau, A | 1 |
| Judkins, A | 1 |
| Hahn, SM | 2 |
| Koch, CJ | 2 |
| Scheuermann, JS | 1 |
| Divgi, C | 1 |
| Kachur, AV | 1 |
| Freifelder, R | 1 |
| Reddin, JS | 1 |
| Karp, J | 1 |
| Stubbs, JB | 1 |
| Driesbaugh, J | 1 |
| Smith, D | 1 |
| Prendergast, S | 1 |
| Marcus, KJ | 1 |
| Dutton, SC | 1 |
| Barnes, P | 1 |
| Coleman, CN | 2 |
| Pomeroy, SL | 1 |
| Goumnerova, L | 1 |
| Billett, AL | 1 |
| Kieran, M | 1 |
| Tarbell, NJ | 1 |
| Chang, EL | 1 |
| Loeffler, JS | 1 |
| Riese, NE | 1 |
| Wen, PY | 1 |
| Alexander, E | 1 |
| Black, PM | 1 |
| Newman, HF | 1 |
| Bleehen, NM | 1 |
| Ward, R | 1 |
| Workman, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer[NCT01881451] | 5 participants (Actual) | Observational | 2013-08-31 | Terminated (stopped due to Due to slow accrual and access to the study drug.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for etanidazole and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.
Topics: Biological Transport; Brain Neoplasms; Cell Hypoxia; Etanidazole; Female; Fluorine Radioisotopes; Gl | 2010 |
A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma.
Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Stem Neoplasms; Child; Child, Preschool | 2003 |
Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brachytherapy; Brain Neoplasms; Etanidazole; Feasib | 1998 |
2 other studies available for etanidazole and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Animals; Brain Neoplasms; Etanidazole; Gliob | 2008 |
Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Brain Neoplasms; Drug Therapy, Combination; Etanidazole; Glioblastoma; Humans; Nitroimidazoles; Radi | 1988 |