etanidazole has been researched along with Anoxemia in 36 studies
Etanidazole: A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.
etanidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Changes in tumor hypoxia were assessed by comparing the binding of two hypoxia tracers, pimonidazole and EF5 given before and after Atrasentan administration." | 7.75 | Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model. ( Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM, 2009) |
| "A method has been developed for the synthesis of [18F]fluoroetanidazole, a potential tracer for imaging hypoxia with positron emission tomography." | 7.69 | Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia. ( Tewson, TJ, 1997) |
| " Hypoxia in plaques was verified by using an EF5 adduct-specific antibody and pimonidazole." | 3.77 | Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice. ( Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S, 2011) |
| " Changes in tumor hypoxia were assessed by comparing the binding of two hypoxia tracers, pimonidazole and EF5 given before and after Atrasentan administration." | 3.75 | Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model. ( Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM, 2009) |
| "A method has been developed for the synthesis of [18F]fluoroetanidazole, a potential tracer for imaging hypoxia with positron emission tomography." | 3.69 | Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia. ( Tewson, TJ, 1997) |
| " The plasma half-life was 11." | 2.70 | Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles. ( Covey, JM; Evans, SM; Hahn, SM; Koch, CJ; McKenna, WG; Rockwell, K, 2001) |
| "Misonidazole is a metabolically active drug." | 2.37 | Biochemistry of reduction of nitro heterocycles. ( Astor, MB; Biaglow, JE; Clark, EP; Epp, ER; Hall, EJ; Roizen-Towle, L; Varnes, ME, 1986) |
| "Tissues from six human brain tumors were assessed." | 1.35 | Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. ( Dilling, T; Evans, SM; Hahn, SM; Jenkins, KW; Jenkins, WT; Judkins, A; Judy, KD; Koch, CJ; Schrlau, A, 2008) |
| "Etanidazole was more cytotoxic at pH 6." | 1.28 | Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole. ( Herman, TS; Holden, SA; Teicher, BA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.11) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 14 (38.89) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Narva, SI | 1 |
| Seppänen, MP | 1 |
| Raiko, JRH | 1 |
| Forsback, SJ | 1 |
| Orte, KJ | 1 |
| Virtanen, JM | 1 |
| Hynninen, J | 1 |
| Hietanen, S | 1 |
| Sperry, MM | 1 |
| Yu, YH | 1 |
| Kartha, S | 1 |
| Ghimire, P | 1 |
| Welch, RL | 1 |
| Winkelstein, BA | 1 |
| Granquist, EJ | 1 |
| Speicher, PJ | 1 |
| Beasley, GM | 1 |
| Jiang, B | 1 |
| Lidsky, ME | 1 |
| Palmer, GM | 1 |
| Scarbrough, PM | 1 |
| Mosca, PJ | 1 |
| Dewhirst, MW | 1 |
| Tyler, DS | 1 |
| Evans, SM | 9 |
| Jenkins, KW | 1 |
| Jenkins, WT | 4 |
| Dilling, T | 1 |
| Judy, KD | 2 |
| Schrlau, A | 1 |
| Judkins, A | 1 |
| Hahn, SM | 3 |
| Koch, CJ | 14 |
| Yang, KM | 1 |
| Russell, J | 1 |
| Lupu, ME | 1 |
| Cho, H | 1 |
| Li, XF | 1 |
| Koutcher, JA | 1 |
| Ling, CC | 1 |
| Silvola, JM | 1 |
| Saraste, A | 1 |
| Forsback, S | 1 |
| Laine, VJ | 1 |
| Saukko, P | 1 |
| Heinonen, SE | 1 |
| Ylä-Herttuala, S | 1 |
| Roivainen, A | 1 |
| Knuuti, J | 1 |
| Abe, C | 1 |
| Uto, Y | 1 |
| Nakae, T | 1 |
| Shinmoto, Y | 1 |
| Sano, K | 1 |
| Nakata, H | 1 |
| Teraoka, M | 1 |
| Endo, Y | 1 |
| Maezawa, H | 1 |
| Masunaga, S | 1 |
| Nakata, E | 1 |
| Hori, H | 2 |
| Carlin, S | 1 |
| Humm, JL | 1 |
| Sugishita, Y | 1 |
| Watanabe, M | 1 |
| Fisher, SA | 1 |
| Cairns, RA | 1 |
| Hill, RP | 1 |
| Dunphy, I | 1 |
| Hwang, WT | 1 |
| Nelson, PT | 1 |
| Lustig, RA | 1 |
| Jenkins, K | 1 |
| Magarelli, DP | 1 |
| Collins, RA | 1 |
| Grady, MS | 1 |
| Vordermark, D | 1 |
| Han, M | 1 |
| Trotta, P | 1 |
| Coleman, C | 1 |
| Linask, KK | 1 |
| Schrlau, AE | 1 |
| Chalian, AA | 1 |
| Zhang, P | 1 |
| Roizin-Towle, L | 1 |
| Biaglow, JE | 2 |
| Meltzer, HL | 1 |
| Varnes, ME | 2 |
| Skov, KA | 1 |
| MacPhail, S | 1 |
| Waleh, NS | 1 |
| Brody, MD | 1 |
| Knapp, MA | 1 |
| Mendonca, HL | 1 |
| Lord, EM | 6 |
| Laderoute, KR | 1 |
| Sutherland, RM | 1 |
| Laughlin, KM | 1 |
| Tracy, M | 1 |
| Chan, CY | 1 |
| Shapiro, M | 1 |
| Tewson, TJ | 1 |
| Shapiro, IM | 1 |
| Clyman, RI | 3 |
| Bergeron, M | 2 |
| Ferriero, DM | 2 |
| Sharp, FR | 2 |
| Hermeking, H | 1 |
| Kitsis, RN | 1 |
| Geenen, DL | 1 |
| Bialik, S | 1 |
| MacManus, JP | 1 |
| Jian, M | 1 |
| Walker, T | 1 |
| Zurakowski, B | 1 |
| Dolbier, WR | 1 |
| Li, AR | 1 |
| Shiue, CY | 1 |
| Kachur, AV | 1 |
| Fenton, BM | 1 |
| Paoni, SF | 1 |
| Seidner, SR | 1 |
| Chen, YQ | 2 |
| Oprysko, PR | 1 |
| Mauray, F | 2 |
| Tse, MM | 1 |
| Lin, E | 1 |
| Koch, C | 1 |
| Rockwell, K | 1 |
| Covey, JM | 1 |
| McKenna, WG | 1 |
| Kajino, H | 1 |
| Goldbarg, S | 1 |
| Roman, C | 1 |
| Liu, BM | 1 |
| Takahashi, Y | 1 |
| Teicher, BA | 1 |
| Herman, TS | 1 |
| Holden, SA | 1 |
| Sasai, K | 1 |
| Shibamoto, Y | 1 |
| Takahashi, M | 1 |
| Zhou, L | 1 |
| Nagasawa, H | 1 |
| Shibata, T | 1 |
| Inayama, S | 1 |
| Abe, M | 1 |
| Hirst, DG | 1 |
| Adams, GE | 1 |
| Stratford, IJ | 1 |
| Roizen-Towle, L | 1 |
| Clark, EP | 1 |
| Epp, ER | 1 |
| Astor, MB | 1 |
| Hall, EJ | 1 |
| Rootman, J | 1 |
| Gallie, B | 1 |
| Kumi, C | 1 |
| Bussanich, N | 1 |
| Rogers, B | 1 |
| Palcic, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer[NCT01881451] | 5 participants (Actual) | Observational | 2013-08-31 | Terminated (stopped due to Due to slow accrual and access to the study drug.) | |||
| Pilot Study to Characterize the HRHV Axis in the Microenvironment of Breast Cancers[NCT01055678] | Early Phase 1 | 0 participants (Actual) | Interventional | 2010-01-31 | Withdrawn (stopped due to PI left Duke) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for etanidazole and Anoxemia
| Article | Year |
|---|---|
PET of hypoxia: current and future perspectives.
Topics: Etanidazole; Humans; Hydrocarbons, Fluorinated; Hypoxia; Nitroimidazoles; Positron-Emission Tomograp | 2012 |
Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.
Topics: Animals; Biochemistry; Etanidazole; Flow Cytometry; Humans; Hydrocarbons, Fluorinated; Hypoxia; Immu | 2002 |
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neopl | 1986 |
Biochemistry of reduction of nitro heterocycles.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Division; Cell Survival; Etanidazole; Free Radicals; | 1986 |
1 trial available for etanidazole and Anoxemia
| Article | Year |
|---|---|
Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.
Topics: Area Under Curve; Body Weight; Chromatography, High Pressure Liquid; Etanidazole; Half-Life; Humans; | 2001 |
31 other studies available for etanidazole and Anoxemia
| Article | Year |
|---|---|
Imaging of Tumor Hypoxia With 18F-EF5 PET/MRI in Cervical Cancer.
Topics: Cell Hypoxia; Etanidazole; Female; Fluorine Radioisotopes; Humans; Hydrocarbons, Fluorinated; Hypoxi | 2021 |
Intra-articular etanercept attenuates pain and hypoxia from TMJ loading in the rat.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Etanercept; Etanidazole; Female; Hydrocarbons | 2020 |
Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Etanidazole; Feasibility Studies; Female; Follow-Up Studies | 2014 |
Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Animals; Brain Neoplasms; Etanidazole; Gliob | 2008 |
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gado | 2009 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Diseas | 2011 |
Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo.
Topics: Animals; Antineoplastic Agents; Chick Embryo; Chorioallantoic Membrane; Disease Models, Animal; Dose | 2011 |
Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract.
Topics: Animals; Apoptosis; Chick Embryo; DNA Primers; Etanidazole; Gene Expression; Heart; Hydrocarbons, Fl | 2004 |
Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma.
Topics: Animals; Disease Models, Animal; Etanidazole; Female; Humans; Hydrocarbons, Fluorinated; Hypoxia; In | 2004 |
Hypoxia is important in the biology and aggression of human glial brain tumors.
Topics: Aged; Brain Neoplasms; Electrodes; Etanidazole; Glioma; Humans; Hydrocarbons, Fluorinated; Hypoxia; | 2004 |
Significance of hypoxia in malignant glioma. Re: Evans et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 2004;10:8177-84.
Topics: Antineoplastic Agents; Brain Neoplasms; Etanidazole; Glioma; Humans; Hydrocarbons, Fluorinated; Hypo | 2005 |
MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment.
Topics: Animals; Avian Proteins; Basigin; Biomarkers; Cell Differentiation; Chick Embryo; Etanidazole; Hydro | 2006 |
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.
Topics: Aged; Antibodies, Monoclonal; Dermis; Etanidazole; Female; Fluorescence; Humans; Hydrocarbons, Fluor | 2006 |
Factors associated with the preincubation effect of hypoxic cell sensitizers in vitro and their possible implications in chemosensitization.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cysteamine; Dose-Response Relationship, Drug; D | 1984 |
Low concentrations of nitroimidazoles: effective radiosensitizers at low doses.
Topics: Animals; CHO Cells; Cricetinae; Etanidazole; Hypoxia; In Vitro Techniques; Misonidazole; Nimorazole; | 1994 |
Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.
Topics: Carcinoma; Colonic Neoplasms; Endothelial Growth Factors; Etanidazole; Gene Expression Regulation, N | 1995 |
Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.
Topics: Animals; Antineoplastic Agents; Etanidazole; Hydrocarbons, Fluorinated; Hypoxia; Mice; Mice, Inbred | 1996 |
Evaluation of the concept of "hypoxic fraction" as a descriptor of tumor oxygenation status.
Topics: Animals; Benzimidazoles; Cell Hypoxia; Cell Survival; Etanidazole; Fluorescent Dyes; Glioma; Humans; | 1997 |
Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia.
Topics: Etanidazole; Fluorine Radioisotopes; Hypoxia; Isotope Labeling; Radiation-Sensitizing Agents; Radiop | 1997 |
Imaging hypoxia and blood flow in normal tissues.
Topics: Animals; Antibodies, Monoclonal; Chickens; Etanidazole; Growth Plate; Humans; Hydrocarbons, Fluorina | 1997 |
Imaging hypoxia in diseased tissues.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Brain Ischemia; Colonic Neoplasms; Etanidazole; H | 1997 |
Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia.
Topics: Acute Disease; Animals; Animals, Newborn; Antibodies, Monoclonal; Brain; Cell Hypoxia; Cerebral Cort | 1999 |
Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1.
Topics: Animals; Brain Ischemia; Carrier Proteins; Cell Cycle Proteins; Cerebral Infarction; Cerebrovascular | 1999 |
[18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.
Topics: Animals; Chromatography, High Pressure Liquid; Etanidazole; Fluorine Radioisotopes; Humans; Hydrocar | 2001 |
Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.
Topics: Animals; Borates; Calcium Compounds; Disease Models, Animal; Etanidazole; Female; Hydrocarbons, Fluo | 2001 |
Combined prostaglandin and nitric oxide inhibition produces anatomic remodeling and closure of the ductus arteriosus in the premature newborn baboon.
Topics: Animals; Animals, Newborn; Bisbenzimidazole; Blood Pressure; Cardiovascular Agents; DNA Fragmentatio | 2001 |
Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Cell Death; Cell Hypoxia; Ductus Arteriosus; Etan | 2002 |
Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole.
Topics: Animals; Benzimidazoles; Cell Division; Cell Line; Cell Survival; Etanidazole; Fibrosarcoma; Flow Cy | 1991 |
KIH-802, an acetohydroxamic acid derivative of 2-nitroimidazole, as a new potent hypoxic cell radiosensitizer: radiosensitizing activity, acute toxicity, and pharmacokinetics.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Female; Hydrox | 1990 |
Tumour radiosensitization by clofibrate and its analogs: possible mechanisms.
Topics: Animals; Bezafibrate; Clofibrate; Combined Modality Therapy; Etanidazole; Female; Hypoxia; Mice; Mic | 1990 |
Ocular penetration, toxicity, and radiosensitization effects of two hypoxic cell radiosensitizers on retinoblastoma.
Topics: Absorption; Animals; Cell Line; Etanidazole; Eye; Eye Neoplasms; Female; Hypoxia; Nitroimidazoles; R | 1986 |